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Showing 1–24 of 509 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mild Traumatic Brain Injury Clear all
Not listed Phase 3 Interventional

Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)

NCT02089594
View directory record Official record
Conditions
Post-Concussion Syndrome, Traumatic Brain Injury
Interventions
Hyperbaric Oxygen, No Hyperbaric Oxygen
Drug
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Jul 20, 2026, 1:09 AM EDT
Not listed Early Phase 1 Interventional

Photobiomodulation to Improve Cognition in TBI, With fMRI

NCT04230577
View directory record Official record
Conditions
Traumatic Brain Injury, Closed Head Injury, Cognitive Dysfunction
Interventions
Real LED Intervention, Sham LED Intervention
Device
Lead sponsor
Boston VA Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2022 · Synced Jul 20, 2026, 1:09 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Spectacles Lens in Concussed Kids

NCT03123822
View directory record Official record
Conditions
Concussion, Mild, Convergence Insufficiency, Accommodation; Insufficiency
Interventions
Glasses
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
9 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 22, 2022 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Return to Learn Implementation Bundle for Schools (RISE) After Youth Concussion

NCT04635475
View directory record Official record
Conditions
Concussion, Mild
Interventions
RISE Bundle
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
14 Years to 19 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aerobic Exercise for Concussion

NCT02959216
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Acute Brain Injury, Brain Concussion
Interventions
Aerobic Exercise, Stretching Exercise
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
13 Years to 18 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
3
States / cities
Boston, Massachusetts • Buffalo, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional

Cognitive-Communication Screening and Early Therapy for Adults With Mild TBI

NCT03230656
View directory record Official record
Conditions
Concussion, Mild Traumatic Brain Injury, Cognitive Communication Disorder
Interventions
Early cognitive-communication therapy
Other
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Jul 20, 2026, 1:09 AM EDT
Terminated Not applicable Interventional

A Comparison Between Cardiovascular Exercise Modes Following Sport Related Concussion

NCT04586179
View directory record Official record
Conditions
Concussion, Mild, Sport Injury
Interventions
Aerobic (treadmill) Exercise, Dynamic (Agility) Exercise
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 35 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vestibular Treatment in Adolescents Following Sport Related Concussion

NCT03555370
View directory record Official record
Conditions
Vestibular Disorder
Interventions
Vestibular Exercise Intervention, Standard of Care
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional

Internet-guided Cognitive Behavioral Therapy for Insomnia in Military Service Members With History of TBI

NCT04377009
View directory record Official record
Conditions
Insomnia Chronic, Mild Traumatic Brain Injury
Interventions
Sleep Healthy Using the Internet (SHUTi), Education Control Program
Device · Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Jul 20, 2026, 1:09 AM EDT
Not listed Not applicable Interventional

PoNS Clinical Experience Program (TBI)

NCT03852732
View directory record Official record
Conditions
Mild to Moderate Traumatic Brain Injury
Interventions
PoNS Treatment
Device
Lead sponsor
Helius Medical Inc
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 18, 2019 · Synced Jul 20, 2026, 1:09 AM EDT
Recruiting Not applicable Interventional

Neuromodulation and Neurorehabilitation for mTBI

NCT03819608
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
Interventions
real iTBS, real APT, placebo APT, placebo iTBS
Device · Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 20, 2026, 1:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Blood Biomarker Study to Diagnose Adolescent Sport Concussion

NCT05287997
View directory record Official record
Conditions
Brain Concussion
Interventions
Neurolytixs Index
Diagnostic Test
Lead sponsor
Neurolytixs
Industry
Eligibility
13 Years to 17 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Brighton, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Jul 20, 2026, 1:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Control Study of Nautilus BrainPulse for the Detection of Concussion

NCT02350699
View directory record Official record
Conditions
Brain Concussion
Interventions
Nautilus BrainPulse
Device
Lead sponsor
Jan Medical, Inc.
Industry
Eligibility
14 Years to 19 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Mountain View, California
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Jul 20, 2026, 1:09 AM EDT
Recruiting Not applicable Interventional

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

NCT05663034
View directory record Official record
Conditions
Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress, Sleep, Memory Impairment, Cognitive Behavioral Therapy, Concussion, Brain, Head Injury, Brain Injury Traumatic Mild
Interventions
Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
5
States / cities
Eglin Air Force Base, Florida • Bethesda, Maryland • Fort Bragg, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 20, 2026, 1:09 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Concussion Assessment, Young Adults and Adults

NCT03249675
View directory record Official record
Conditions
Concussion, Brain
Interventions
Not listed
Lead sponsor
ElMindA Ltd
Industry
Eligibility
12 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Brighton, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Environmental Distractions on SCAT6 Outcomes

NCT05886400
View directory record Official record
Conditions
Concussion, Brain, Mild Traumatic Brain Injury
Interventions
SCAT6, Visual/ Auditory Distraction
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 30 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 23, 2024 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Phase 2 Interventional

Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)

NCT01220713
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Interventions
Hyperbaric Oxygen Therapy
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
19 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Portsmouth, Virginia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2013 · Synced Jul 20, 2026, 1:09 AM EDT
Terminated Not applicable Interventional

Blood Flow Restriction Concussion

NCT03695042
View directory record Official record
Conditions
Concussion Post Syndrome
Interventions
Blood Flow Restriction Training with Exercise
Other
Lead sponsor
Duke University
Other
Eligibility
14 Years to 30 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Phase 2 Interventional Results available

Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)

NCT01306968
View directory record Official record
Conditions
Post-concussive Symptoms, Traumatic Brain Injury
Interventions
hyperbaric oxygen, sham hyperbaric air
Drug · Other
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
5
States / cities
Camp Pendleton, California • Fort Carson, Colorado • Fort Gordon, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Jul 20, 2026, 1:09 AM EDT
Completed No phase listed Observational

S-100B as Pre-Head CT Scan Screening Test After Mild Traumatic Brain Injury

NCT00717301
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
Not listed
Enrollment
1,252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
6
States / cities
Albany, New York • Buffalo, New York • Cooperstown, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2015 · Synced Jul 20, 2026, 1:09 AM EDT
Terminated Phase 3 Interventional Results available

Study to Evaluate the Safety, Tolerability, and Efficacy of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury

NCT00983437
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Armodafinil
Drug
Lead sponsor
Cephalon, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
61
States / cities
Birmingham, Alabama • Tucson, Arizona • Hot Springs, Arkansas + 49 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Nerve Stimulation For Enhancing Human and Cognitive Performance

NCT05675956
View directory record Official record
Conditions
Concussion, Mild, Autonomic Nervous System, Cognitive
Interventions
Experimental group with 100% intensity setting on Apollo Neuro device, Active Comparator group with 10% intensity setting on the Apollo Neuro device
Device
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 35 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Jul 20, 2026, 1:09 AM EDT
Withdrawn Not applicable Interventional

Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial)

NCT02125591
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Active CN-NINM PoNS, Sham CN-NINM PoNS
Device
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 21, 2015 · Synced Jul 20, 2026, 1:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Concussion Education Programs

NCT04492696
View directory record Official record
Conditions
Concussion, Brain
Interventions
Education
Other
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 19 Years · Male only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Jul 20, 2026, 1:09 AM EDT