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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Misuse, Opioid Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

NCT07179614
View directory record Official record
Conditions
Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders
Interventions
Overdose Prevention Intervention Package (OPIP)
Behavioral
Lead sponsor
Michele Staton
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Harlan, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Not applicable Interventional

Program for Pain & Prescription Opioid Use in Pregnancy

NCT02804152
View directory record Official record
Conditions
Pain, Opioid Abuse, Pregnancy
Interventions
CBT for Chronic Pain in Pregnancy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2022 · Synced Jul 23, 2026, 7:08 PM EDT
Recruiting Not applicable Interventional

The ENHANCE Project Toolkit

NCT07649278
View directory record Official record
Conditions
Substance Related Disorder, Drug Overdose, eHealth
Interventions
Connections mHealth Application
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Completed No phase listed Observational Results available

User Acceptability of a Device-Based Opioid Overdose Intervention

NCT04530591
View directory record Official record
Conditions
Opioid Overdose, Opioid-use Disorder, Substance Use Disorders
Interventions
Survey, Interview
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Jul 23, 2026, 7:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Patient Reported Outcomes for Opioid Use Disorder

NCT03985163
View directory record Official record
Conditions
Opioid-use Disorder, Overdose of Opiate, Patient Participation
Interventions
Patient Reported Outcomes Electronic Survey
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Jul 23, 2026, 7:08 PM EDT
Not listed Not applicable Interventional

The Impact of a Web-Based Naloxone Intervention Under Standing Orders to Patients Prescribed Chronic Opioid Therapy

NCT03337009
View directory record Official record
Conditions
Overdose, Risk Behavior
Interventions
Naloxone Navigator (NN)
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,004 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 19, 2024 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Not applicable Interventional

Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders

NCT03241771
View directory record Official record
Conditions
Opioid Abuse, Overdose, Risk Behavior
Interventions
Naloxone Navigator 1.0
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
325 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Jul 23, 2026, 7:08 PM EDT
Recruiting Not applicable Interventional

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

NCT06806163
View directory record Official record
Conditions
Opioid Overdose, Opioid Use, Opioid Use Disorder, Opioids
Interventions
EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges, Usual Care
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1,350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Parenting Young Children Study

NCT05180487
View directory record Official record
Conditions
Parenting, Parent-Child Relations, Opioid Misuse, Opioid Use Disorder, Stress, Depression, Parenting Self-efficacy
Interventions
Family Check-Up
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years and older
Enrollment
356 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Increasing Implementation of Post-Operative Opioid Prescribing Guidelines

NCT05358522
View directory record Official record
Conditions
Surgery, Opioid Use, Opioid Misuse, Prescription Opioid Misuse
Interventions
Opioid Prescribing Report Cards
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
Not listed
Enrollment
26,562 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2024 · Synced Jul 23, 2026, 7:08 PM EDT
Completed No phase listed Observational

Incidence and Predictors of Opioid Overdose and Death Among Long-Term Users of Opioid Analgesics

NCT02662153
View directory record Official record
Conditions
Opioid Overdose
Interventions
Observation only
Other
Lead sponsor
Member Companies of the Opioid PMR Consortium
Industry
Eligibility
18 Years to 79 Years
Enrollment
808,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
4
States / cities
Wilmington, Delaware • Boston, Massachusetts • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Jul 23, 2026, 7:08 PM EDT
Completed No phase listed Observational

Natural Language Processing for Screening Opioid Misuse

NCT05745480
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Misuse
Interventions
Opioid Misuse Screening with an Addiction Consult Service
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
47,502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers

NCT02572089
View directory record Official record
Conditions
Drug Overdose, Opioid-Related Disorders
Interventions
Naloxone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 23, 2026, 7:08 PM EDT
Not yet recruiting Phase 4 Interventional

A Bundled Intervention to End Opioid Overdoses

NCT07485335
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Overdose
Interventions
Bundled intervention (Experimental), control group, Buprenorphine (Experimental), Scheduled Peer Support Specialist (Experimental), Telemedicine Buprenorphine Treatment
Other · Drug · Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Active, not recruiting Not applicable Interventional

Evaluating an Intervention to Prevent Overdoses in Rural and Urban Counties

NCT05463341
View directory record Official record
Conditions
Opiate Overdose, Fentanyl Overdose, Harm Reduction
Interventions
Fentanyl Test Strips
Behavioral
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
18 Years and older
Enrollment
2,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Not applicable Interventional Results available

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose

NCT03838510
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
REBOOT
Behavioral
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 65 Years
Enrollment
268 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
San Francisco, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Jul 23, 2026, 7:08 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Clinical Decision Support to Improve System Naloxone Co-prescribing

NCT06271668
View directory record Official record
Conditions
Medication Abuse, Harm Reduction, Opioid Overdose, Opioid Prescribing
Interventions
Naloxone Co-prescribing Clinical Decision Support (CDS)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 89 Years
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Suspended Phase 2 Interventional Accepts healthy volunteers

Reducing Opioid Use and Misuse After Wisdom Molar Extractions

NCT04414917
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Twin block, iPill dispenser
Drug · Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Not listed Not applicable Interventional

Collaborative Opioid Taper After Trauma: Preventing Opioid Misuse and Opioid Use Disorder

NCT04275258
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative, Opioid Use, Unspecified, Trauma, Opioid-use Disorder
Interventions
Provide assistance to subject's rural PCP pertaining to subject/patient pain management goals and opioid taper plan
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Empower Opioid Misuse & Chronic Pain

NCT04184362
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
Empower Neuromodulation System Transcutaneous Electrical Nerve Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2023 · Synced Jul 23, 2026, 7:08 PM EDT
Not listed Not applicable Interventional

Improving Availability of Intranasal Naloxone

NCT05877118
View directory record Official record
Conditions
Opioid Overdose
Interventions
Enhanced Overdose Education (EOE), Standard education
Behavioral
Lead sponsor
Hartford Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 6, 2024 · Synced Jul 23, 2026, 7:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Prescription Opioid Misuse: ROPEs Pilot Trial

NCT03691948
View directory record Official record
Conditions
Knowledge, Attitudes, Practice
Interventions
Responsible Opioid Prescriber Education (ROPES), Active Comparator Control
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Jul 23, 2026, 7:08 PM EDT
Active, not recruiting Not applicable Interventional

Mobile Peer Support for OUD Recovery

NCT05405712
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Mobile Phone App
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
1,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Indianapolis, Indiana • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jul 23, 2026, 7:08 PM EDT
Recruiting Phase 3 Interventional

Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial

NCT06200181
View directory record Official record
Conditions
Misuse, Opioid
Interventions
Olanzapine, Placebo
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 23, 2026, 7:08 PM EDT