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Showing 1–24 of 146 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Mitral Heart Valve Disease Clear all
Completed Not applicable Interventional Results available

Real World Expanded Multicenter Study of the MitraClip® System (REALISM)

NCT01931956
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
MitraClip® implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
965 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
38
States / cities
Los Angeles, California • Mountain View, California • Sacramento, California + 31 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting Not applicable Interventional

ATLAS (AltaValve) Pivotal Trial

NCT06465745
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
Interventions
AltaValve System.
Device
Lead sponsor
4C Medical Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
36
States / cities
Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 30 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting Not applicable Interventional

AMEND TS Early Feasibility Study

NCT06951672
View directory record Official record
Conditions
Symptomatic Functional MR 3 or Greater
Interventions
This study will evaluate the safety and functionality of the AMEND™ Trans-Septal System for annuloplasty as a therapy for mitral regurgitation.
Device
Lead sponsor
Valcare Medical Ltd.
Industry
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
11
States / cities
Phoenix, Arizona • La Jolla, California • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Not listed Not applicable Interventional

Evaluating Infrasonic Hemodynography

NCT04636892
View directory record Official record
Conditions
Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic, Cardiovascular Diseases, Coronary Artery Disease
Interventions
MindMics earbud
Other
Lead sponsor
Scripps Health
Other
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting Not applicable Interventional

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

NCT03142152
View directory record Official record
Conditions
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
Interventions
Carillon Mitral Contour System, Guideline Directed Heart Failure Medication
Device · Other
Lead sponsor
Cardiac Dimensions, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
75
States / cities
Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 61 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Completed No phase listed Observational

The Short Form-36: Pre- Versus Post-Surgical Administration in Cardiac Surgery Patients

NCT00226265
View directory record Official record
Conditions
Coronary Artery Bypass Grafting, Heart Diseases, Heart Valve Diseases
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Sep 29, 2026, 12:02 AM EDT
Not listed Not applicable Interventional

Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement

NCT04717570
View directory record Official record
Conditions
Mitral Valve Disease, Mitral Valve Stenosis, Mitral Valve Failure
Interventions
Foldax TRIA Mitral Valve
Device
Lead sponsor
Foldax, Inc
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Carmel, Indiana • Wichita, Kansas • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting Not applicable Interventional

EFS of Posterior Leaflet Replacement to Reduce Mitral Regurgitation (United States)

NCT07517588
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
MR-ace Implant and Delivery System
Device
Lead sponsor
Polares Medical SA
Industry
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
3
States / cities
Atlanta, Georgia • The Bronx, New York • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Not listed No phase listed Observational

The Effects of Degenerative Mitral Regurgitation on Cardiac Structure and Function, Symptoms, and Exercise Capacity

NCT04051411
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Not listed
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Sep 29, 2026, 12:02 AM EDT
Not listed Not applicable Interventional

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

NCT04770961
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions
Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Sep 29, 2026, 12:02 AM EDT
Active, not recruiting No phase listed Observational

Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

NCT05526560
View directory record Official record
Conditions
Mitral Stenosis, Mitral Valve Insufficiency
Interventions
MITRIS RESILIA Mitral Valve, Model 11400M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
504 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2035
U.S. locations
20
States / cities
Newport Beach, California • Palo Alto, California • Orlando, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Not listed No phase listed Observational

Primary Mitral Regurgitation Repair

NCT04067635
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Prolapse, Chronic Mitral Disease, Mitral Regurgitation, Mitral Valve Disease, Degenerative Mitral Valve Disease, Myxomatous Mitral Valve Degeneration, Ventricular Remodeling
Interventions
Not listed
Lead sponsor
Eric Y. Yang, MD PhD
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 29, 2026, 12:02 AM EDT
Completed No phase listed Observational Results available

The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices

NCT03502811
View directory record Official record
Conditions
Mitral Valve Regurgitation, Mitral Regurgitation
Interventions
MitraClip NTR/XTR System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
1,041 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
22
States / cities
Birmingham, Alabama • Phoenix, Arizona • La Jolla, California + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting Not applicable Interventional

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

NCT04029337
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Transcatheter Mitral Valve Replacement
Device
Lead sponsor
HighLife SAS
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
10
States / cities
Tucson, Arizona • Los Angeles, California • Atlanta, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting No phase listed Observational

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

NCT06780241
View directory record Official record
Conditions
Aortic Regurgitation, Mitral Regurgitation, Aortic Stenosis
Interventions
CMR, Quality of Life Questionnaire
Diagnostic Test · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting No phase listed Observational

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

NCT04761120
View directory record Official record
Conditions
Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
Interventions
Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring, Abbott SJM Tailor Band
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
2
States / cities
Durham, North Carolina • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Active, not recruiting Not applicable Interventional

Beating Heart Mitral Valve Repair With the HARPOON™ System

NCT04375332
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
HARPOON™ Beating Heart Mitral Valve Repair System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
21 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
9
States / cities
San Francisco, California • Atlanta, Georgia • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Terminated Not applicable Interventional Results available

Cardiovalve Transfemoral Mitral Valve System

NCT03813524
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cardiovalve Transfemoral Mitral Valve
Device
Lead sponsor
Cardiovalve Ltd.
Industry
Eligibility
18 Years to 84 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Completed Phase 2 Interventional Results available

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

NCT00807040
View directory record Official record
Conditions
Mitral Valve Insufficiency, Coronary Artery Disease
Interventions
Mitral Valve Repair with Annuloplasty, Mitral Valve Replacement
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
18
States / cities
Los Angeles, California • Atlanta, Georgia • Marietta, Georgia + 15 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Sep 29, 2026, 12:02 AM EDT
Recruiting Not applicable Interventional

Cephea Early Feasibility Study

NCT05061004
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cephea Mitral Valve System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
20
States / cities
Phoenix, Arizona • Los Angeles, California • Sacramento, California + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Completed Not applicable Interventional Results available

Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery

NCT02675244
View directory record Official record
Conditions
Mild Tricuspid Regurgitation, Moderate Tricuspid Regurgitation, Tricuspid Regurgitation
Interventions
TV Annuloplasty, MVS
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
24
States / cities
Los Angeles, California • Stanford, California • New Haven, Connecticut + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 29, 2026, 12:02 AM EDT
Completed Not applicable Interventional Results available

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

NCT01757665
View directory record Official record
Conditions
Aortic Stenosis, Mitral Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Heart Failure
Interventions
Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 29, 2026, 12:02 AM EDT
Completed Phase 4 Interventional Results available

The Use of Paravertebral Block for Cardiac Surgery

NCT02180893
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
Paravertebral Block, Placebo Comparator
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Sep 29, 2026, 12:02 AM EDT
Not listed Phase 1 Interventional

VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study

NCT00512005
View directory record Official record
Conditions
Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure, Mitral Insufficiency, Mitral Incompetence, Ischemic Heart Disease
Interventions
Percutaneous mitral valve repair
Device
Lead sponsor
Myocor
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
4
States / cities
Atlanta, Georgia • Evanston, Illinois • Shawnee Mission, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2009 · Synced Sep 29, 2026, 12:02 AM EDT