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ClinicalTrials.gov public records Last synced Sep 28, 2026, 7:51 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Mitral Valve Insufficiency Clear all
Recruiting No phase listed Observational

Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

NCT06770062
View directory record Official record
Conditions
Left Ventricular Systolic Dysfunction
Interventions
Cardiac MRI
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Recruiting No phase listed Observational

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

NCT04761120
View directory record Official record
Conditions
Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
Interventions
Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring, Abbott SJM Tailor Band
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
2
States / cities
Durham, North Carolina • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Acute Ketone Supplementation on the Brain

NCT07711990
View directory record Official record
Conditions
Brain Health
Interventions
Ketone Ester Drink, Placebo
Dietary Supplement
Lead sponsor
Christopher Crabtree
Other
Eligibility
45 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multimodal Investigation of Neural Plasticity

NCT06453980
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
sham tDCS, active tDCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Recruiting Not applicable Interventional

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

NCT06221852
View directory record Official record
Conditions
Bipolar I Disorder, Psychosis, Schizoaffective Disorder
Interventions
Ketogenic diet, Dietary Guidelines for Americans
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Active, not recruiting Not applicable Interventional

Beating Heart Mitral Valve Repair With the HARPOON™ System

NCT04375332
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
HARPOON™ Beating Heart Mitral Valve Repair System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
21 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
9
States / cities
San Francisco, California • Atlanta, Georgia • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Terminated Not applicable Interventional Results available

Cardiovalve Transfemoral Mitral Valve System

NCT03813524
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cardiovalve Transfemoral Mitral Valve
Device
Lead sponsor
Cardiovalve Ltd.
Industry
Eligibility
18 Years to 84 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Phase 2 Interventional Results available

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

NCT00807040
View directory record Official record
Conditions
Mitral Valve Insufficiency, Coronary Artery Disease
Interventions
Mitral Valve Repair with Annuloplasty, Mitral Valve Replacement
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
18
States / cities
Los Angeles, California • Atlanta, Georgia • Marietta, Georgia + 15 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Sep 28, 2026, 7:51 PM EDT
Recruiting Not applicable Interventional

Cephea Early Feasibility Study

NCT05061004
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cephea Mitral Valve System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
20
States / cities
Phoenix, Arizona • Los Angeles, California • Sacramento, California + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cortical GABA Concentrations in Insomnia

NCT00765752
View directory record Official record
Conditions
Insomnia, Major Depression
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
25 Years to 55 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 20, 2013 · Synced Sep 28, 2026, 7:51 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Study of New Magnetic Resonance Methods

NCT00001844
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Not applicable Interventional Results available

Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery

NCT02675244
View directory record Official record
Conditions
Mild Tricuspid Regurgitation, Moderate Tricuspid Regurgitation, Tricuspid Regurgitation
Interventions
TV Annuloplasty, MVS
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
24
States / cities
Los Angeles, California • Stanford, California • New Haven, Connecticut + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Not applicable Interventional Results available

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

NCT01757665
View directory record Official record
Conditions
Aortic Stenosis, Mitral Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Heart Failure
Interventions
Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Phase 4 Interventional Results available

The Use of Paravertebral Block for Cardiac Surgery

NCT02180893
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
Paravertebral Block, Placebo Comparator
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Sep 28, 2026, 7:51 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major Depression

NCT01465165
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Paul Carlson
Other
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 18, 2017 · Synced Sep 28, 2026, 7:51 PM EDT
Not listed Phase 1 Interventional

VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study

NCT00512005
View directory record Official record
Conditions
Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure, Mitral Insufficiency, Mitral Incompetence, Ischemic Heart Disease
Interventions
Percutaneous mitral valve repair
Device
Lead sponsor
Myocor
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
4
States / cities
Atlanta, Georgia • Evanston, Illinois • Shawnee Mission, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2009 · Synced Sep 28, 2026, 7:51 PM EDT
Recruiting Not applicable Interventional

Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)

NCT07130994
View directory record Official record
Conditions
Mitral Regurgitation, Heart Disease
Interventions
Mitral Valve Replacement
Device
Lead sponsor
InnovHeart
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
5
States / cities
Los Angeles, California • Sacramento, California • Thousand Oaks, California + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Not applicable Interventional

Evaluating Therapeutic Response to Novo-TTF

NCT02441322
View directory record Official record
Conditions
Glioblastoma Multiforme
Interventions
Novo-TTF
Device
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Sep 28, 2026, 7:51 PM EDT
Recruiting Phase 2 Interventional

5-HTP and Creatine for Depression R33 Phase

NCT05895747
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Low Dose 5-hydroxytryptophan, High Dose 5-hydroxytryptophan, Low Dose Creatine Monohydrate, High Dose Creatine Monohydrate, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity

NCT02677740
View directory record Official record
Conditions
Non-invasive Neuromodulation in Healthy Subjects
Interventions
Inhibitory rTMS (1 Hz), Excitatory rTMS (5 Hz)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 40 Years · Male only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease

NCT00933608
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
memantine, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
55 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2014 · Synced Sep 28, 2026, 7:51 PM EDT
Completed No phase listed Observational

Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes

NCT04400513
View directory record Official record
Conditions
Murmur, Heart, Aortic Valve Stenosis, Tricuspid Regurgitation, Mitral Regurgitation, Innocent Murmurs, Heart Murmurs
Interventions
Use of Eko CORE and Eko DUO electronic stethoscopes
Device
Lead sponsor
Eko Devices, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Sep 28, 2026, 7:51 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery

NCT00082121
View directory record Official record
Conditions
Myocardial Ischemia, Coronary Arteriosclerosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
Interventions
TP10
Drug
Lead sponsor
Avant Immunotherapeutics
Industry
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
18
States / cities
San Francisco, California • Washington D.C., District of Columbia • Gainesville, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2007 · Synced Sep 28, 2026, 7:51 PM EDT
Completed No phase listed Observational

Investigation of Heart Function in Patients With Heart Valve Defects

NCT00001314
View directory record Official record
Conditions
Aortic Valve Insufficiency, Mitral Valve Insufficiency
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1992 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 28, 2026, 7:51 PM EDT