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Showing 1–24 of 56 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Moderate Traumatic Brain Injury Clear all
Completed Phase 1 Interventional

Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury

NCT02974959
View directory record Official record
Conditions
Traumatic Brain Injury, Acute Brain Injuries
Interventions
gammaCore active device, gammaCore sham device
Device
Lead sponsor
CentraCare
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury

NCT03307070
View directory record Official record
Conditions
Major Depressive Disorder, Traumatic Brain Injury
Interventions
Cognitive Behavioral Therapy for individuals with TBI, Waitlist Control
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2023 · Synced Jun 25, 2026, 5:34 PM EDT
Withdrawn No phase listed Observational

Noninvasive Monitoring of Cerebral Blood Flow Autoregulation in Patients With Traumatic Brain Injury (TBI)

NCT01605838
View directory record Official record
Conditions
Traumatic Brain Injury (TBI)
Interventions
Not listed
Lead sponsor
Advanced Brain Monitoring, Inc.
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2015 · Synced Jun 25, 2026, 5:34 PM EDT
Recruiting Not applicable Interventional

GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI

NCT06028334
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
GetUp&Go, GetUp&Go with 10-Week Delay
Behavioral
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Elkins Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jun 25, 2026, 5:34 PM EDT
Withdrawn Not applicable Interventional

Foundations in Developing Precision Cognitive Restoration

NCT05117502
View directory record Official record
Conditions
Moderate Cognitive Impairment, Traumatic Brain Injury, Stroke
Interventions
intermittent Theta Burst Stimulation, Placebo intermittent Theta Burst Stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Jun 25, 2026, 5:34 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

NCT04124029
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
Interventions
No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
Device · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 90 Years
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury

NCT04530032
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
ketogenic/modified Atkins diet, Standard diet
Other
Lead sponsor
Loma Linda University
Other
Eligibility
16 Years to 90 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury

NCT03169647
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Listening-based intervention
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 59 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Jun 25, 2026, 5:34 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries

NCT05307640
View directory record Official record
Conditions
Trauma, Brain
Interventions
CG-Well, Information Support & Referral (ISR)
Behavioral
Lead sponsor
Natalie Kreitzer
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Jun 25, 2026, 5:34 PM EDT
Recruiting Phase 1Phase 2 Interventional

Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

NCT06282965
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Angiotensin (1-7), Sterile saline
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury

NCT04933448
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Ketogenic Diet
Other
Lead sponsor
Gillette Children's Specialty Healthcare
Other
Eligibility
2 Years to 17 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jun 25, 2026, 5:34 PM EDT
Recruiting Not applicable Interventional

Emotional Awareness Therapy Study

NCT07624825
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
TREAT-A, TREAT-B
Behavioral
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Edison, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jun 25, 2026, 5:34 PM EDT
Recruiting Phase 2Phase 3 Interventional

FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial

NCT06062888
View directory record Official record
Conditions
Moderate to Severe Traumatic Brain Injury
Interventions
Fresh Frozen Plasma (FFP)
Biological
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Enrollment
357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jun 25, 2026, 5:34 PM EDT
Not yet recruiting Phase 2 Interventional

Ketamine Treatment for PTSD and MDD in TBI

NCT06228391
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
Interventions
IV ketamine, Midazolam
Drug
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 28, 2024 · Synced Jun 25, 2026, 5:34 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Valproic AcId for Traumatic BRAin INjury Trial

NCT07166393
View directory record Official record
Conditions
Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury
Interventions
Valproic Acid (VPA), Standard of care treatment + normal saline
Drug · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Phase 1Phase 2 Interventional

Progesterone Treatment of Blunt Traumatic Brain Injury

NCT00048646
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
IV Progesterone
Drug
Lead sponsor
David Wright
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2014 · Synced Jun 25, 2026, 5:34 PM EDT
Not listed Not applicable Interventional

PoNS Clinical Experience Program (TBI)

NCT03881202
View directory record Official record
Conditions
Mild to Moderate Traumatic Brain Injury
Interventions
PoNS Treatment
Device
Lead sponsor
Helius Medical Inc
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 18, 2019 · Synced Jun 25, 2026, 5:34 PM EDT
Not listed Not applicable Interventional

Strategy + RehaCom for Memory Rehabilitation in Traumatic Brain Injury (TBI)

NCT04239456
View directory record Official record
Conditions
Traumatic Brain Injury With Loss of Consciousness
Interventions
RehaCom (software)
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI)

NCT01058395
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Minocycline
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years · Male only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
Dearborn, Michigan • Trenton, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Jun 25, 2026, 5:34 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury

NCT02990078
View directory record Official record
Conditions
TBI
Interventions
Sildenafil citrate, Functional Near Infared Spectroscopy, Hypercapnia Challenge
Drug · Device · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD

NCT03283163
View directory record Official record
Conditions
Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD), Mild or Moderate Traumatic Brain Injury
Interventions
Exercise Testing and Training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 60 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Study of Safety and Effectiveness of PoNS Device to Treat Chronic Balance Deficit Due to Traumatic Brain Injury (TBI)

NCT02429167
View directory record Official record
Conditions
Traumatic Brain Injury, Chronic Balance Disorder
Interventions
Cranial nerve non-invasive neuromodulation via PoNS device, Sham PoNS device
Device
Lead sponsor
Helius Medical Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Orlando, Florida • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Jun 25, 2026, 5:34 PM EDT
Completed Not applicable Interventional

Walking After Traumatic Brain Injury in Older Adults

NCT06222502
View directory record Official record
Conditions
Traumatic Brain Injury, TBI, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Interventions
Planning, Reminders, and Micro-Incentives, Health Education
Other
Lead sponsor
Timothy Morris
Other
Eligibility
40 Years to 80 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jun 25, 2026, 5:34 PM EDT
Completed No phase listed Observational

Biomarkers of Mild and Moderate Traumatic Brain Injury

NCT01295346
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Head CT scan and blood draw
Other
Lead sponsor
Banyan Biomarkers, Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
5
States / cities
Gainesville, Florida • Decatur, Georgia • Lawrenceville, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Jun 25, 2026, 5:34 PM EDT