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ClinicalTrials.gov public records Last synced Sep 29, 2026, 11:50 PM EDT

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Showing 25–48 of 56 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Moderate Traumatic Brain Injury (TBI) Clear all
Completed Not applicable Interventional

Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury

NCT04530032
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
ketogenic/modified Atkins diet, Standard diet
Other
Lead sponsor
Loma Linda University
Other
Eligibility
16 Years to 90 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 29, 2026, 11:50 PM EDT
Withdrawn Not applicable Interventional

Cognitive Rehabilitation and Brain Activity of Attention-Control Impairment in TBI

NCT04199130
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
BrainHQ, Goal Management Training
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 22, 2021 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI)

NCT01058395
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Minocycline
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years · Male only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
Dearborn, Michigan • Trenton, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Not applicable Interventional

Effect of Trunk Support on Academic Engagement of Children With Severe Disability

NCT05391594
View directory record Official record
Conditions
Cerebral Palsy, Traumatic Brain Injury, Metabolic Disease, Hypotonia
Interventions
customized posture support
Device
Lead sponsor
University of Hartford
Other
Eligibility
3 Months to 21 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Cheshire, Connecticut • Hartford, Connecticut • Wethersfield, Connecticut
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Not applicable Interventional

Screening and Brief Intervention for Substance Misuse Following Traumatic Brain Injury

NCT02129361
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Adapted Screening and Brief Intervention (Adapted SBI), Screening & Education Attention Control
Behavioral
Lead sponsor
Jennifer Bogner, PhD, ABPP
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2021 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Not applicable Interventional Results available

Clinical Trial of a Rehabilitation Game - SuperBetter

NCT01398566
View directory record Official record
Conditions
Concussion, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Interventions
SuperBetter play
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
15 Years to 25 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 6, 2021 · Synced Sep 29, 2026, 11:50 PM EDT
Recruiting Phase 1Phase 2 Interventional

Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

NCT06282965
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Angiotensin (1-7), Sterile saline
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Not applicable Interventional

Walking After Traumatic Brain Injury in Older Adults

NCT06222502
View directory record Official record
Conditions
Traumatic Brain Injury, TBI, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Interventions
Planning, Reminders, and Micro-Incentives, Health Education
Other
Lead sponsor
Timothy Morris
Other
Eligibility
40 Years to 80 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 29, 2026, 11:50 PM EDT
Not listed Not applicable Interventional

An Innovative Supportive Care Model for Dementia and Traumatic Brain Injury

NCT04495686
View directory record Official record
Conditions
Dementia, Mixed, Dementia Mild, Dementia Moderate, Traumatic Brain Injury, Alzheimer Disease
Interventions
Telehealth-delivered Care Coordination Program
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
21 Years and older
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Sep 29, 2026, 11:50 PM EDT
Recruiting Not applicable Interventional

Goal-oriented Telehealth Rehabilitation of Executive Functioning for Veterans With Chronic TBI

NCT07190365
View directory record Official record
Conditions
Mild to Moderate Traumatic Brain Injury, Cognitive Rehabilitation, Veteran
Interventions
GOALS TH, EDU TH
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Phase 1Phase 2 Interventional

Progesterone Treatment of Blunt Traumatic Brain Injury

NCT00048646
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
IV Progesterone
Drug
Lead sponsor
David Wright
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 19, 2014 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Phase 2 Interventional Results available

Sumatriptan as Treatment for Post-traumatic Headache

NCT01854385
View directory record Official record
Conditions
Post-traumatic Headache
Interventions
Sumatriptan 100 mg
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Sep 29, 2026, 11:50 PM EDT
Not listed Not applicable Interventional

PoNS Clinical Experience Program (TBI)

NCT03881202
View directory record Official record
Conditions
Mild to Moderate Traumatic Brain Injury
Interventions
PoNS Treatment
Device
Lead sponsor
Helius Medical Inc
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Sep 29, 2026, 11:50 PM EDT
Recruiting Not applicable Interventional

Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons

NCT05048966
View directory record Official record
Conditions
Traumatic Brain Injury, Mild Traumatic Brain Injury, Alzheimer's Disease, Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe, Dementia
Interventions
Group Wellness Class 1, Group Wellness Class 2
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Not applicable Interventional

The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL

NCT04901286
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Exercise Only, Exercise + Non-Immersive Virtual Reality, Exercise + Immersive Virtual Reality
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Phase 1 Interventional

Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury

NCT02974959
View directory record Official record
Conditions
Traumatic Brain Injury, Acute Brain Injuries
Interventions
gammaCore active device, gammaCore sham device
Device
Lead sponsor
CentraCare
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Sep 29, 2026, 11:50 PM EDT
Withdrawn Not applicable Interventional

Foundations in Developing Precision Cognitive Restoration

NCT05117502
View directory record Official record
Conditions
Moderate Cognitive Impairment, Traumatic Brain Injury, Stroke
Interventions
intermittent Theta Burst Stimulation, Placebo intermittent Theta Burst Stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Sep 29, 2026, 11:50 PM EDT
Terminated No phase listed Observational

Biomarkers of Brain Injury: Magnitude and Outcome of Mild and Moderate TBI

NCT01786447
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Not listed
Lead sponsor
Banyan Biomarkers, Inc
Industry
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 12, 2013 · Synced Sep 29, 2026, 11:50 PM EDT
Recruiting Phase 1 Interventional

Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury

NCT05716048
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
KF-mSMT Plus Aerobic Exercise Training, KF-mSMT Plus Stretching Exercise Training
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 29, 2026, 11:50 PM EDT
Active, not recruiting Not applicable Interventional

Intervention to Change Affect Recognition and Empathy

NCT05636020
View directory record Official record
Conditions
Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes, Concussion With Brief Loss of Consciousness, Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With Loss of Consciousness, Traumatic Brain Injury With Prolonged Loss of Consciousness, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter, Traumatic Brain Injury With No Loss of Consciousness, Traumatic Brain Injury With Open Intracranial Wound, Traumatic Brain Injury With Moderate Loss of Consciousness
Interventions
ICARE Treatment
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 29, 2026, 11:50 PM EDT
Recruiting Not applicable Interventional

Emotional Awareness Therapy Study

NCT07624825
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
TREAT-A, TREAT-B
Behavioral
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Edison, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 29, 2026, 11:50 PM EDT
Terminated Phase 2 Interventional

A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.

NCT00735085
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
SLV334, Placebo
Drug
Lead sponsor
Abbott Products
Industry
Eligibility
16 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
5
States / cities
Baltimore, Maryland • Dayton, Ohio • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2011 · Synced Sep 29, 2026, 11:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury

NCT03163901
View directory record Official record
Conditions
Vestibular Disorder, Headache, Traumatic Brain Injury
Interventions
Osteopathic Manipulative Treatment
Other
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Mason, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2020 · Synced Sep 29, 2026, 11:50 PM EDT
Terminated Phase 3 Interventional Results available

Study to Evaluate the Safety, Tolerability, and Efficacy of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury

NCT00983437
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Armodafinil
Drug
Lead sponsor
Cephalon, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
61
States / cities
Birmingham, Alabama • Tucson, Arizona • Hot Springs, Arkansas + 49 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2021 · Synced Sep 29, 2026, 11:50 PM EDT