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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Moderate to Severe Traumatic Brain Injury Clear all
Completed Not applicable Interventional

Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury

NCT03307070
View directory record Official record
Conditions
Major Depressive Disorder, Traumatic Brain Injury
Interventions
Cognitive Behavioral Therapy for individuals with TBI, Waitlist Control
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2023 · Synced Jun 25, 2026, 8:30 PM EDT
Withdrawn No phase listed Observational

Noninvasive Monitoring of Cerebral Blood Flow Autoregulation in Patients With Traumatic Brain Injury (TBI)

NCT01605838
View directory record Official record
Conditions
Traumatic Brain Injury (TBI)
Interventions
Not listed
Lead sponsor
Advanced Brain Monitoring, Inc.
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2015 · Synced Jun 25, 2026, 8:30 PM EDT
Recruiting Not applicable Interventional

GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI

NCT06028334
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
GetUp&Go, GetUp&Go with 10-Week Delay
Behavioral
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Elkins Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jun 25, 2026, 8:30 PM EDT
Completed Not applicable Interventional

Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury

NCT04530032
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
ketogenic/modified Atkins diet, Standard diet
Other
Lead sponsor
Loma Linda University
Other
Eligibility
16 Years to 90 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jun 25, 2026, 8:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries

NCT05307640
View directory record Official record
Conditions
Trauma, Brain
Interventions
CG-Well, Information Support & Referral (ISR)
Behavioral
Lead sponsor
Natalie Kreitzer
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Jun 25, 2026, 8:30 PM EDT
Recruiting Phase 1Phase 2 Interventional

Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

NCT06282965
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Angiotensin (1-7), Sterile saline
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jun 25, 2026, 8:30 PM EDT
Completed Not applicable Interventional

Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury

NCT04933448
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Ketogenic Diet
Other
Lead sponsor
Gillette Children's Specialty Healthcare
Other
Eligibility
2 Years to 17 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jun 25, 2026, 8:30 PM EDT
Recruiting Not applicable Interventional

Emotional Awareness Therapy Study

NCT07624825
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
TREAT-A, TREAT-B
Behavioral
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Edison, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jun 25, 2026, 8:30 PM EDT
Recruiting Phase 2Phase 3 Interventional

FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial

NCT06062888
View directory record Official record
Conditions
Moderate to Severe Traumatic Brain Injury
Interventions
Fresh Frozen Plasma (FFP)
Biological
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Enrollment
357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jun 25, 2026, 8:30 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Valproic AcId for Traumatic BRAin INjury Trial

NCT07166393
View directory record Official record
Conditions
Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury
Interventions
Valproic Acid (VPA), Standard of care treatment + normal saline
Drug · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Jun 25, 2026, 8:30 PM EDT
Not listed Not applicable Interventional

Strategy + RehaCom for Memory Rehabilitation in Traumatic Brain Injury (TBI)

NCT04239456
View directory record Official record
Conditions
Traumatic Brain Injury With Loss of Consciousness
Interventions
RehaCom (software)
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Jun 25, 2026, 8:30 PM EDT
Completed No phase listed Observational

Characterization & Treatment of Chronic Pain After Moderate to Severe TBI

NCT03739307
View directory record Official record
Conditions
Traumatic Brain Injury, Pain
Interventions
Not listed
Lead sponsor
Craig Hospital
Other
Eligibility
16 Years and older
Enrollment
3,805 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
13
States / cities
Birmingham, Alabama • Englewood, Colorado • Tampa, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Jun 25, 2026, 8:30 PM EDT
Completed Not applicable Interventional

Strategy Based Technique to Enhance Memory (STEM) for Improving New Learning and Memory (NLM) in Moderate to Severe TBI

NCT04054596
View directory record Official record
Conditions
Traumatic Brain Injury, Cognitive Impairment
Interventions
SME
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jun 25, 2026, 8:30 PM EDT
Recruiting Phase 1 Interventional

Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury

NCT05716048
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
KF-mSMT Plus Aerobic Exercise Training, KF-mSMT Plus Stretching Exercise Training
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Jun 25, 2026, 8:30 PM EDT
Terminated Phase 2 Interventional

A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.

NCT00735085
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
SLV334, Placebo
Drug
Lead sponsor
Abbott Products
Industry
Eligibility
16 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
5
States / cities
Baltimore, Maryland • Dayton, Ohio • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2011 · Synced Jun 25, 2026, 8:30 PM EDT
Completed Phase 2 Interventional Results available

Sumatriptan as Treatment for Post-traumatic Headache

NCT01854385
View directory record Official record
Conditions
Post-traumatic Headache
Interventions
Sumatriptan 100 mg
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Jun 25, 2026, 8:30 PM EDT
Terminated Phase 2 Interventional Results available

Early Propranolol After Traumatic Brain Injury: Phase II

NCT01202110
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Propranolol
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Jun 25, 2026, 8:30 PM EDT
Completed Not applicable Interventional

Effect of Trunk Support on Academic Engagement of Children With Severe Disability

NCT05391594
View directory record Official record
Conditions
Cerebral Palsy, Traumatic Brain Injury, Metabolic Disease, Hypotonia
Interventions
customized posture support
Device
Lead sponsor
University of Hartford
Other
Eligibility
3 Months to 21 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Cheshire, Connecticut • Hartford, Connecticut • Wethersfield, Connecticut
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Jun 25, 2026, 8:30 PM EDT
Terminated Phase 2 Interventional Results available

Effects of Huperzine A in Treatment of Moderate to Severe TBI

NCT01676311
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Huperzine A, Placebo
Drug
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced Jun 25, 2026, 8:30 PM EDT
Withdrawn Not applicable Interventional

Cognitive Rehabilitation and Brain Activity of Attention-Control Impairment in TBI

NCT04199130
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
BrainHQ, Goal Management Training
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 21, 2021 · Synced Jun 25, 2026, 8:30 PM EDT
Active, not recruiting Not applicable Interventional

Intervention to Change Affect Recognition and Empathy

NCT05636020
View directory record Official record
Conditions
Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes, Concussion With Brief Loss of Consciousness, Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With Loss of Consciousness, Traumatic Brain Injury With Prolonged Loss of Consciousness, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter, Traumatic Brain Injury With No Loss of Consciousness, Traumatic Brain Injury With Open Intracranial Wound, Traumatic Brain Injury With Moderate Loss of Consciousness
Interventions
ICARE Treatment
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jun 25, 2026, 8:30 PM EDT