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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Molar, Third Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Efficacy Study of XPF-001 to Treat Pain Following Wisdom Tooth Extraction

NCT00954356
View directory record Official record
Conditions
Dental Pain
Interventions
XPF-001, placebo
Drug
Lead sponsor
Xenon Pharmaceuticals Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 15, 2012 · Synced Jun 10, 2026, 8:18 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Oral Specimen and Data Acquisition Study of Subjects Requiring Third Molar Removal

NCT01805869
View directory record Official record
Conditions
Stomatognatic, Tooth Diseases, Diseases, Tooth, Tooth Impaction
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
16 Years to 50 Years
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 10, 2026, 8:18 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

NCT04860141
View directory record Official record
Conditions
Dental Pain and Sensation Disorder, Pain, Postoperative
Interventions
Gabapentin 600mg, Placebo
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 59 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jun 10, 2026, 8:18 PM EDT
Not yet recruiting Phase 2 Interventional

Jaw Muscle Pain Post Wisdom Molar Surgery

NCT07094542
View directory record Official record
Conditions
Post Operative Pain, Impacted Third Molar Tooth, Muscle Pain
Interventions
Temporo-masseteric Nerve Block Injection, Oral Pain Medications only
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional

Capsaicin to Control Pain Following Third Molar Extraction

NCT00088686
View directory record Official record
Conditions
Healthy, Tooth Extraction
Interventions
Capsaicin (Intramucosal Injection)
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 3 Interventional Results available

A Randomized, Self Controlled Clinical Study of Hemostatic Efficacy of the HemCon Dental Dressing

NCT00707486
View directory record Official record
Conditions
Tooth Extractions
Interventions
Hemcon Dental Dressing, Gauze with Pressure and/or Gelfoam
Device
Lead sponsor
HemCon Medical Technologies, Inc
Industry
Eligibility
14 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Milwaukie, Oregon • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 8, 2013 · Synced Jun 10, 2026, 8:18 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Efficacy Study of IV Ibuprofen vs IV Acetaminophen Post Surgical Extraction

NCT02133326
View directory record Official record
Conditions
Impacted Wisdom Teeth
Interventions
Caldolor, Ofirmev
Drug
Lead sponsor
Tufts University School of Dental Medicine
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 19, 2017 · Synced Jun 10, 2026, 8:18 PM EDT
Completed No phase listed Observational

Diagnosis, Evaluation and Treatment of Patients in Need of Third Molar Removal

NCT00316485
View directory record Official record
Conditions
Wisdom Teeth
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
18 Years to 50 Years
Enrollment
718 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional

A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction

NCT00542035
View directory record Official record
Conditions
Dental Pain
Interventions
ARRY-371797, p38 inhibitor; oral, Placebo; oral
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
2
States / cities
San Marcos, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Jun 10, 2026, 8:18 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Auto Transplantation of Wisdom Teeth

NCT06553300
View directory record Official record
Conditions
Autotransplantation of Wisdom Teeth, Patelet Rich Fibrin
Interventions
Autotransplantation with PRF, Autotransplatation Only
Procedure
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Evaluating Ability of HT-6184 to Reduce Inflammation and Pain After Third Molar Extraction

NCT06241742
View directory record Official record
Conditions
Pain
Interventions
HT-6184, HT-6184 Placebo
Drug
Lead sponsor
Halia Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Jun 10, 2026, 8:18 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Feasibility Testing of a New Way to Support the Jaw During 3rd Molar Extractions

NCT03512769
View directory record Official record
Conditions
Impacted Third Molar Tooth, Temporomandibular Joint Dysfunction Syndrome
Interventions
Restful Jaw Device
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 24 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Jun 10, 2026, 8:18 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multimodal Analgesic Protocol to Moderate Acute Pain

NCT03456141
View directory record Official record
Conditions
Pain, Post-operative
Interventions
third molar surgery
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional

Bradykinin Receptors and Pain

NCT00083356
View directory record Official record
Conditions
Tooth, Impacted
Interventions
Wisdom tooth extraction
Procedure
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
Not listed
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional

Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction

NCT00001724
View directory record Official record
Conditions
Pain
Interventions
Flurbiprofen
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Ibuprofen Extended-Release Dental Pain Study

NCT00707057
View directory record Official record
Conditions
Pain, Post-Operative Pain, Third Molar Extraction
Interventions
Ibuprofen 600 mg Extended-Release Tablets, Placebo
Drug
Lead sponsor
SCOLR Pharma, Inc.
Industry
Eligibility
16 Years to 45 Years
Enrollment
256 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 23, 2011 · Synced Jun 10, 2026, 8:18 PM EDT
Terminated Phase 2 Interventional

An Analgesic Study to of V117957 for the Treatment of Postsurgical Pain Due to Third Molar Extraction

NCT01900795
View directory record Official record
Conditions
Postsurgical Pain Due to Third Molar Extraction
Interventions
V117957, Ibuprofen, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years to 45 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 4, 2013 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional

Capsaicin to Control Pain Following Third Molar Extraction

NCT00008476
View directory record Official record
Conditions
Facial Pain
Interventions
Capsaicin
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional

Study of Acetaminophen (ACE) in Post-operative Dental Pain

NCT02320708
View directory record Official record
Conditions
Dental Pain
Interventions
Acetaminophen (ACE) (1000 mg), Commercial ACE (1000 mg), Commercial Ibuprofen (IBU) (400 mg), Placebo
Drug
Lead sponsor
Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.
Industry
Eligibility
17 Years to 50 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 2, 2021 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation

NCT03255824
View directory record Official record
Conditions
Anesthesia
Interventions
Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 35 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional Results available

Study of Long-Acting Acetaminophen in Postoperative Dental Pain

NCT01960114
View directory record Official record
Conditions
Dental Pain
Interventions
Acetaminophen ER, Placebo
Drug
Lead sponsor
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Industry
Eligibility
17 Years to 45 Years
Enrollment
403 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Study Testing Ketamine Sublingual Wafer After Wisdom Tooth Extraction

NCT02356965
View directory record Official record
Conditions
Pain
Interventions
Ketamine, Placebo (for Ketamine)
Drug
Lead sponsor
iX Biopharma Ltd.
Other
Eligibility
18 Years to 38 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Jun 10, 2026, 8:18 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Variability in Analgesic Response to Ibuprofen

NCT06539741
View directory record Official record
Conditions
Impacted Third Molar Tooth, Pain, Acute
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 10, 2026, 8:18 PM EDT
Completed Phase 3 Interventional Results available

Multiple Dose Dental Pain Study Of Ibuprofen Extended Release

NCT01266161
View directory record Official record
Conditions
Pain
Interventions
Ibuprofen 600 mg ER, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
16 Years to 40 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Jun 10, 2026, 8:18 PM EDT