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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mood Disturbance Clear all
Recruiting Not applicable Interventional

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

NCT05414708
View directory record Official record
Conditions
PTSD, Military Activity, Post-Traumatic Headache, Posttraumatic Stress Disorder, Posttraumatic Stress Disorder, Delayed Onset, Sleep Disturbance, Nightmare, Irritable Mood, Anger, Combat and Operational Stress Reaction, Combat Stress Disorders, Military Family, Military Operations, Emotional Regulation, Emotion Processing
Interventions
Art Therapy
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Health Benefits of Gardening

NCT03266120
View directory record Official record
Conditions
Anxiety, Depression, Healthy, Mood Disturbance, Stress, Quality of Life, Physical Activity, Social Interaction
Interventions
Art, Gardening
Other
Lead sponsor
University of Florida
Other
Eligibility
26 Years to 49 Years · Female only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional

Art Therapy QEEG Study for Service Members with a Traumatic Brain Injury and Posttraumatic Stress Symptoms

NCT04776304
View directory record Official record
Conditions
Post-Traumatic Headache, PTSD, TBI, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Posttraumatic Stress Disorder, Delayed Onset, Sleep Disturbance, Nightmare, Nightmares, REM-Sleep Type, Headache, Irritable Mood, Anger, Eating Disorders, Combat and Operational Stress Reaction, Combat Stress Disorders, Military Operations, Military Activity, Military Family
Interventions
Art Therapy
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional Results available

Personalized Integrated Chronotherapy for Perinatal Depression

NCT04364646
View directory record Official record
Conditions
Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation, Pregnancy Related, Sleep Disturbance
Interventions
Personalized Integrated Chronotherapy
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Glen Oaks, New York • Chapel Hill, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Jul 22, 2026, 5:51 AM EDT
Terminated Phase 3 Interventional

Add-On Ramelteon in Bipolar I Disorder With Clinically Significant Sleep Disturbance

NCT00585208
View directory record Official record
Conditions
Insomnia, Bipolar Disorder
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
Lindner Center of HOPE
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Mason, Ohio
Source: ClinicalTrials.gov public record
Updated May 9, 2013 · Synced Jul 22, 2026, 5:51 AM EDT
Recruiting Not applicable Interventional

Patient-clinical Linkages to Improve Trust and Engagement in Postpartum Healthcare

NCT06481631
View directory record Official record
Conditions
Family Dynamics, Trust in Healthcare System, Family Structure, Health Literacy, Contraception, Maternal Behavior, Postpartum Mood Disturbance
Interventions
The PEN-3 Intervention Model
Behavioral
Lead sponsor
Jackson State University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 22, 2026, 5:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sleep More, Stress Less: 90-Day Trial of Neuralli Mood

NCT07717385
View directory record Official record
Conditions
Psychological Stress, Sleep Disturbance, Anxiety Symptoms, Depressive Symptoms, Occupational Burnout
Interventions
Neuralli Mood
Dietary Supplement
Lead sponsor
Efforia, Inc
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Exercise on Acute Nicotine Withdrawal

NCT01047930
View directory record Official record
Conditions
Nicotine Dependence, Smoking, Sleep Disorders, Intrinsic
Interventions
Exercise
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 45 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Phase 3 Interventional

Group Therapy for Primary Breast Cancer

NCT00220792
View directory record Official record
Conditions
Breast Cancer
Interventions
Brief supportive-expressive group therapy
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
Female only
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 1998
U.S. locations
10
States / cities
Wichita, Kansas • Kalamazoo, Michigan • Saint Louis Park, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2024 · Synced Jul 22, 2026, 5:51 AM EDT
Active, not recruiting Not applicable Interventional

An Intervention to Enhance Well-Being in Trauma Exposed New Mothers

NCT05474534
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Dissociation, Maternal Care Patterns, Infant Behavior, Maternal Behavior, Maternal Distress, Mood Disturbance, Emotional Regulation
Interventions
Neurofeedback (MUSE 2)
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Jul 22, 2026, 5:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adolescent Mood During Puberty and Testosterone

NCT06072677
View directory record Official record
Conditions
Adolescent Depression
Interventions
Healthy Minds Program
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
11 Years to 14 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional

Night Respite for Postpartum Mothers With SUD

NCT05746507
View directory record Official record
Conditions
Opioid Use Disorder, Maternal Drugs Affecting Fetus, Postpartum Mood Disturbance, Sleep Disorder, Neonatal Opioid Withdrawal
Interventions
Night Respite Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Mattapan, Massachusetts • Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Phase 4 Interventional Results available

A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth

NCT03911414
View directory record Official record
Conditions
Mood Disturbance, Mood Disorders, Natural Supplements, Alternative Treatment
Interventions
Open-label Treatment with Omega-3 Fatty Acids + Inositol, Open-label Treatment with N-acetylcysteine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
5 Years to 17 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional

Family Promoting Positive Emotions Pilot Study

NCT05223842
View directory record Official record
Conditions
Depression, Anhedonia, Stress, Depressive Disorder, Behavioral Symptoms, Mood Disorders, Mental Disorder, Mood Disturbance
Interventions
Family Promoting Positive Emotions (F-PPE), Written Information
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
8 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Impact of Hot Flashes on Sleep and Mood Disturbance

NCT01116401
View directory record Official record
Conditions
Menopause, Depression, Hot Flashes
Interventions
leuprolide
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Phase 3 Interventional

Sleep Disturbance and Bipolar Disorder

NCT00993850
View directory record Official record
Conditions
Bipolar Disorder, Dyssomnias
Interventions
Cognitive behavioral therapy for insomnia, Bipolar education
Behavioral · Other
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2013 · Synced Jul 22, 2026, 5:51 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance

NCT06531863
View directory record Official record
Conditions
Mood Disturbance
Interventions
Curcumin, Epigallocatechin Gallate, Placebo
Dietary Supplement · Other
Lead sponsor
Auburn University
Other
Eligibility
18 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Jul 22, 2026, 5:51 AM EDT
Not listed Not applicable Interventional

A Wearable Nerve Stimulator for Chronic Migraine/Headache and Mood Disturbance in Adolescents

NCT05702528
View directory record Official record
Conditions
Migraine in Adolescence, Headache, Mood Disturbance
Interventions
Apollo Neuro
Device
Lead sponsor
University of South Carolina
Other
Eligibility
10 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Jul 22, 2026, 5:51 AM EDT
Recruiting Not applicable Interventional

RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

NCT05963607
View directory record Official record
Conditions
Chronic Pain, Sleep Disturbance
Interventions
Weighted blanket
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
San Diego, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 22, 2026, 5:51 AM EDT
Active, not recruiting Not applicable Interventional

A Study Comparing the Effects of Two Types of Natural Oils Used in a Bedtime Foot Massage Routine on Sleep and Emotional Well-Being in Perimenopausal Women.

NCT07274371
View directory record Official record
Conditions
Sleep Disturbances in Perimenopause
Interventions
Brahmi-Gotukola oil padabhyanga, Sesame oil Padabhyanga
Behavioral
Lead sponsor
Saipriya Gowrishankar
Other
Eligibility
40 Years to 55 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fairfield, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional

Mindfulness in Mood Dysregulated Youth

NCT02120937
View directory record Official record
Conditions
Bipolar Disorder, Mood Disorder, Emotional Disturbance
Interventions
MBCT-C Therapy
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
10 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Jul 22, 2026, 5:51 AM EDT
Not listed Phase 2 Interventional

Sublingual Tablets With Cannabinoid Combinations for the Treatment of Dysmenorrhea

NCT04091789
View directory record Official record
Conditions
Dysmenorrhea, Headache, Migraine, Fatigue, Nausea, Mood Disturbance
Interventions
Pure Femme Tablets
Drug
Lead sponsor
Pure Green
Industry
Eligibility
21 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Sterling Heights, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Jul 22, 2026, 5:51 AM EDT
Completed Not applicable Interventional

Mindfulness Therapy on Disrupted Sleep in Bipolar Disorder

NCT01764035
View directory record Official record
Conditions
Bipolar Disorder, Insomnia, Hypersomnia, Sleep Problems
Interventions
Body Scan (BS) Meditation Intervention, Brief Supportive Psychotherapy (SP)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2016 · Synced Jul 22, 2026, 5:51 AM EDT
Active, not recruiting Not applicable Interventional

An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers

NCT06054412
View directory record Official record
Conditions
Well-Being, Psychological, Dissociation, Maternal Care Patterns, Maternal Behavior, Maternal Distress, Mood Disturbance, Emotional Regulation, Post Traumatic Stress Disorder
Interventions
Neuroptimal (Zengar, Inc.) Neurofeedback
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Jul 22, 2026, 5:51 AM EDT