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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:51 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 137 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Mood Management Clear all

Conditions: Stress, Anxiety
Interventions: Cyclic Sighing Breathing, Box Breathing, Hypnosis, Audiobook; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Major Depressive Disorder
Interventions: Psychotropic medication (at discretion of psychiatrist), Collaborative psychiatric and primary medical care; Drug · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Bipolar Disorder, Cardiovascular Disease
Interventions: Chronic care model for Bipolar Disorder; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 118 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Bipolar Depression, Suicidal Ideation
Interventions: Ketamine Hydrochloride, Placebo; Drug
Lead sponsor: NeuroRx, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Hollywood, Florida • Fort Worth, Texas

Conditions: Pain Management, Postoperative Pain
Interventions: Psilocybin (Usona Institute), Postoperative analgesia; Drug
Lead sponsor: Trent Emerick; Other
Eligibility: 25 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Dual Diagnosis, Schizophrenia, Bipolar Disorder
Interventions: Benefits Management, Illness Management and Recovery; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Mood, Stress, Psychological
Interventions: From Cancer to Health (C2H-D); Behavioral
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 80 Years
Enrollment: 158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2021
U.S. locations: 15
States / cities: Auburn, Alabama • Sacramento, California • Santa Monica, California + 11 more

Conditions: Depressive Disorder, Major
Interventions: Sertraline and Elzasonan Combination, Sertraline, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 262 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 4
States / cities: Beverly Hills, California • Norwich, Connecticut • New York, New York + 1 more

Conditions: Anxiety, Depression, Depression, Postpartum, Pregnancy Related, CBT
Interventions: Coordinated Anxiety Learning and Management; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Oakland, California

Conditions: Premenstrual Dysphoric Disorder
Interventions: PH80, Placebo intranasal spray; Drug
Lead sponsor: Pherin Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years to 43 Years · Female only
Enrollment: 1,400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Bipolar Disorder, Major Depressive Disorder, Menopause
Interventions: Cognitive Behavioral Group Therapy; Behavioral
Lead sponsor: Danette Conklin, PhD; Other
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Health Promotion and Education, Smoking Cessation Intervention (Actify app), Smoking Cessation Intervention (Current Standard Care app), Survey Administration; Other · Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 242 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Nicotine Dependence
Interventions: Behavioral mood management, Health education; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Major Depressive Disorder, Healthy Volunteer
Interventions: Basimglurant, Placebo; Drug
Lead sponsor: Hoffmann-La Roche; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015
U.S. locations: 1
States / cities: Garden Grove, California

Conditions: Depressive Disorder, Anxiety Disorders, Substance Use Disorders, Post Traumatic Stress Disorder
Interventions: Artificial Intelligence platform for case managers; Other
Lead sponsor: Eleos Health; Industry
Eligibility: 18 Years and older
Enrollment: 280 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Alton, Illinois

Conditions: Depression, Postpartum, Pregnancy, Child Development, Pain, Labor Pain
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older · Female only
Enrollment: 199 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Postpartum Depression (PPD), Alcohol Use, Contingency Management, Problem Solving Therapy
Interventions: Contingency Management & Problem Solving Therapy, Usual Care; Behavioral · Other
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Mood, Cancer Brain
Interventions: Managing Cancer and Living Meaningfully (CALM) Therapy; Behavioral
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Major Depression, Depression
Interventions: Self-help cognitive-behavioral online course; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 547 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Postpartum Depression, Intimate Partner Violence
Interventions: Case Management by Family Support Counselor (not RCT); Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: Female only
Enrollment: 173 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Schizophrenia, Bipolar Disorder, Major Depression
Interventions: Person-Centered Care, Measurement-Based Care; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 2,443 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 2
States / cities: Lebanon, New Hampshire • Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: Lexapro, an antidepressant medicine, Physical Activity, Mood Management Skills, Personalized support from a Family Nurse Practitioner; Drug · Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 25 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Bipolar Disorder
Interventions: Lithium, Divalproex, Placebo; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 16 Years to 65 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2006
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Major Depression
Interventions: Stress Management and Resiliency Training for Depression (SMART-D) Therapy; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 25 Years to 80 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 3
States / cities: Albert Lea, Minnesota • Austin, Minnesota • Rochester, Minnesota

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Stress Management Program

Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing Home

Self-Management Addressing Heart Disease Risk Trial

NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression

Psilocybin After Trauma Surgery for Pain

Benefits Management for People With Psychiatric Disabilities

Stress Management for Cancer Patients: How Well Does it Work? (C2H-D)

A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)

CALM for Pregnant and Post-Partum Women

Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder

Cognitive Behavioral Group Therapy for the Management of Menopause Symptoms in Mood Disorders

mHealth Mood Management Tool (Actify) to Improve Population-Level Smoking Cessation

Adjunctive Mood Management for Telephone-based Smoking Cessation

A Study of the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Dose Basimglurant in Healthy Subjects and in Patients With Major Depressive Disorder (MDD)

AI to Support Mental Health Case Management Providers

Labor Pain and Postpartum Behavioral Health Outcomes Study

Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms

Managing Cancer and Living Meaningfully

Depression Management Project

Case Management Study for Postpartum Depression and Intimate Partner Violence

Person-Centered Versus Measurement-Based Care in Mental Health

PACEPro - Mood Management Pilot

Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder

Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major Depression