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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:19 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 137 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Mood Management Clear all

Conditions: Major Depressive Disorder
Interventions: Escitalopram, Placebo; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Irritable Mood, Temper Tantrum, Anger
Interventions: Parent Management Training; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 10 Years to 14 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Hyperlipidemia, Diabetes, Hypertension
Interventions: Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate, Body mass index, Waist and Hip circumference, Comprehensive Medication Management; Device · Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Duluth, Minnesota

Conditions: Cognitive Therapy, Depression, Postpartum, Mental Health, Depression, Depressive Disorder, Anxiety, Telemedicine
Interventions: Use of smartphone application (app), Treatment as usual; Behavioral · Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 201 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Stanford, California

Conditions: Bipolar Disorder
Interventions: Replicating Effective Programs Framework for the Bipolar Care Model, Bipolar Care Model Package Only; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 384 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 3
States / cities: Denver, Colorado • Ann Arbor, Michigan

Conditions: Bipolar Disorder
Interventions: Uridine; Drug
Lead sponsor: University of Utah; Other
Eligibility: 13 Years to 18 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Major Depressive Disorder
Interventions: Bupropion, Placebo; Drug
Lead sponsor: Affective Neuroscience Laboratory; Other
Eligibility: 18 Years to 64 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 2
States / cities: Boston, Massachusetts • Cambridge, Massachusetts

Conditions: Post-partum Depression
Interventions: Stella (TM) Mobile Application; Device
Lead sponsor: Curio Digital Therapeutics, Inc.; Industry
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
Interventions: Health Care Management and Supported Rehabilitation; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 50 Years and older · Female only
Enrollment: 180 participants
Timeline: 2001 – 2006
U.S. locations: 3
States / cities: Boston, Massachusetts • Nashua, New Hampshire

Conditions: Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension, Anxiety, Atrial Fibrillation, Congestive Heart Failure, Depression, Bipolar Disorder, Schizophrenia
Interventions: High-Touch, High-Tech, Optimal Discharge Planning; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 21 Years and older
Enrollment: 1,400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Hypertension, Hypertension in Pregnancy, Diabetes Mellitus, Gestational Diabetes, Obesity, Depressive Disorder, Anxiety Disorders
Interventions: Default appointment scheduling, Targeted messaging, Nudge Reminders; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cancer Diagnosis, Non-Metastatic Neoplasm, Anxiety, Anxiety Disorders, Depression, Depressive Disorder, Depression, Anxiety, Desmoid
Interventions: Promoting Resilience in Stress Management Program; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years to 39 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Brighton, Massachusetts

Conditions: Depressive Disorder, Depression, Depression, Postpartum, Behavioral Symptoms, Mood Disorders, Mental Disorder, Pregnancy Complications, Postpartum Blues, PPD, Postpartum Disorder
Interventions: Ganaxolone, Placebo; Drug
Lead sponsor: Marinus Pharmaceuticals; Industry
Eligibility: 18 Years to 48 Years · Female only
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 33
States / cities: Glendale, California • Lemon Grove, California • Long Beach, California + 29 more

Conditions: Major Depressive Disorder (MDD)
Interventions: Conversational AI system vs Usual Care; Other
Lead sponsor: George Mason University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Treatment Resistant Depression, Major Depressive Disorder, Severe Depression
Interventions: Ketamine, Midazolam; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Major Depressive Disorder
Interventions: LY03005, Pristiq; Drug
Lead sponsor: Luye Pharma Group Ltd.; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Depression / Major Depressive Disorder, Mental Health (Depression)
Interventions: Stress Management and Resiliency Training with Qigong/Tai Chi, Healthy Living Program; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary, Fibromyalgia, Secondary, Fibromyalgia, Irritable Bowel Syndrome, Chronic Headache Disorder, Chronic Migraine, Chronic Pelvic Pain Syndrome, Temporomandibular Joint Disorders, Endometriosis-related Pain, Arthritis, Chronic Low-back Pain, Failed Back Surgery Syndrome, Post Herpetic Neuralgia, Neuropathic Pain, Painful Diabetic Neuropathy, Painful Bladder Syndrome, Trauma-related Wound, Trauma, Multiple, Chronic Pain Syndrome, Chronic Shoulder Pain
Interventions: SOMA pain manager smartphone application; Device
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Bipolar Disorder
Interventions: Ramelteon, Placebo; Drug
Lead sponsor: Takeda; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 535 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 41
States / cities: Birmingham, Alabama • Anaheim, California • Glendale, California + 38 more

Conditions: Bipolar Depression
Interventions: Levetiracetam, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Drug Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
Interventions: Contingency Management, Non Contingent Control Condition; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 65 Years
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Congestive Heart Failure, Diabetes, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease, Cancer, Cerebrovascular Disease, Alzheimer's Disease, Psychotic Disorder, Major Depression
Interventions: Care Coordination; Behavioral
Lead sponsor: Mathematica Policy Research, Inc.; Other
Eligibility: Not listed
Enrollment: 18,277 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2016
U.S. locations: 15
States / cities: Phoenix, Arizona • Washington D.C., District of Columbia • Sunrise, Florida + 12 more

Conditions: Major Depressive Disorder
Interventions: PHQ-9 - Mirror format; Diagnostic Test
Lead sponsor: Oklahoma State University Center for Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Depression, Depressive Disorder, Depressive Symptoms, Depressive Episode, Adolescent Behavior, Adolescent - Emotional Problem, Hematologic Diseases, Oncology, Weight, Body
Interventions: CBT-based mobile intervention for depression, Mobile control with education about depression; Device
Lead sponsor: Limbix Health, Inc.; Industry
Eligibility: 13 Years to 22 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Dallas, Texas

Search by objective public record fields.

Contact: Developing New Clinical Management Strategies

Parent Management Training to Treat Irritability

Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness

RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood

Adapting the Bipolar Care Model for Chronic Care Management in Community-based Health Care Sites

Oral Uridine for Treatment of Bipolar Depression in Adolescents

The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity

Mobile Application in the Management of Mild to Moderate Postpartum Depression (PPD)

Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older People

Integrated Care (IC) Models for Patient-Centered Outcomes

Bridging the Gap From Postpartum to Primary Care

PRISM for Depression and Anxiety in Young Adults With Cancer

A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

Evaluating Conversational Artificial Intelligence for Depression Management

Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression

A Study of LY03005 vs Pristiq

Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

Safety and Efficacy Study of Ramelteon (TAK-375) Tablets for Sublingual Administration (SL) in Adults With Bipolar 1 Disorder

Levetiracetam in the Management of Bipolar Depression

Contingency Management of Psychostimulant Abuse in the Severely Mentally Ill

Evaluation of Programs of Coordinated Care and Disease Management

Interactive Voice-Based Administration of the PHQ-9

Digital Therapeutic for Adolescent Depressive Symptoms in Hematology, Oncology, and Weight Management