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Conditions: Heart Defects, Congenital
Interventions: Not listed
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: Up to 24 Months
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Oak Lawn, Illinois

Conditions: Mentoring
Interventions: Group-mentoring intervention; Behavioral
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 12 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Autism Spectrum Disorder
Interventions: 12-week FMS Intervention, Physical Activities & Activity Booklets (via FitFamilies app); Other · Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 4 Years to 11 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: MLD, Krabbe Disease, ALD, MPS I, MPS II, MPS III, Vanishing White Matter Disease, GM3 Gangliosidosis, PKAN, Tay-Sachs Disease, NP Deficiency, Osteopetrosis, Alpha-Mannosidosis, Sandhoff Disease, Niemann-Pick Diseases, MPS IV, Gaucher Disease, GAN, GM1 Gangliosidoses, Morquio Disease, S-Adenosylhomocysteine Hydrolase Deficiency, Batten Disease, Pelizaeus-Merzbacher Disease, Leukodystrophy, Lysosomal Storage Diseases, Purine Nucleoside Phosphorylase Deficiency, Multiple Sulfatase Deficiency Disease
Interventions: Palliative Care, Hematopoetic Stem Cell Transplantation; Other · Biological
Lead sponsor: University of Pittsburgh; Other
Eligibility: Not listed
Enrollment: 1,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2035
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Gross Motor Development Delay
Interventions: Parent Educational Program; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Autism, Cerebral Palsy
Interventions: Not listed
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 3 Months to 5 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: AMPD3, OMIM*102772, AMP Deaminase Deficiency, AK1, OMIM *103000, Adenylate Kinase Deficiency, AMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency, TPMT, OMIM *187680, Thoipurines, Poor Metabolism of, IMPDH1, OMIM *146690, Retinitis Pigmentosa Type 10, Leber Congenital Amauriosis Type 11, APRT, OMIM *102600, Adenine Phosphoribosyltransferase Deficiency, HPRT1, OMIM *308000 Lesch-Nyhan Disease, XDH, OMIM *607633, Xanthinuria Type 1, SLC2A9, OMIM *606142 Hypouricemia, SLC22A12, OMIM *607096 Hypouricemia, PRPS1 Def, OMIM *311850, Arts Syndrome; Charcot-Marie-Tooth Disease, PRPS1 SA, OMIM *311850 Gout, PRPS-related Phosphoribosylpyrophosphate Synthetase Superactivity, AMPD2, OMIM *102771, Spastic Paraplegia 63; Pontocerebellar Hypoplasia, ITPA, OMIM *147520, Inosine Triphosphatase Deficiency; Developmental and Epileptic Encephalopathy 35, ADSL, OMIM *608222, Adenylosuccinate Lyase Deficiency, PNP, OMIM *164050, Nucleoside Phosphorylase Deficiency, ADA2, OMIM *607575,Sneddon Syndrome; VAIHS, CAD, *1140120, Developmental and Epileptic Encephalopathy, UPB1, OMIM *606673, Beta-ureidopropionase Deficiency, DPYS, OMIM *613326, Dihydropyrimidinase Deficiency, DPYD, OMIM *274270, Dihydropyrimidine Dehydrogenase Deficiency, DHODH, OMIM *126064, Miller Syndrome (Postaxial Acrofacial Dysostosis), UMPS, OMIM *613891, Orotic Aciduria, NT5C3A<TAB>, OMIM *606224, Anemia, Hemolytic, Due to UMPH1 Deficiency, UNG, OMIM *191525, Hyper-IgM Syndrome 5, AICDA, OMIM *605257, Immunodeficiency With Hyper-IgM, Type 2; HIGM2, Purine-Pyrimidine Metabolism, Metabolic Disease
Interventions: Not listed
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 1 Month to 100 Years
Enrollment: 999 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2099
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Speech Sound Disorder
Interventions: Visual-acoustic biofeedback, Ultrasound biofeedback; Behavioral
Lead sponsor: New York University; Other
Eligibility: 9 Years to 15 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 3
States / cities: Bloomfield, New Jersey • New York, New York • Syracuse, New York

Conditions: Cerebral Palsy
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 18 Months to 12 Years
Enrollment: 724 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 4
States / cities: Atlanta, Georgia • Oklahoma City, Oklahoma • Philadelphia, Pennsylvania + 1 more

Conditions: Developmental Language Disorder
Interventions: Exercise, Restful Play; Behavioral
Lead sponsor: Marquette University; Other
Eligibility: 5 Years to 9 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Ankle Sprains, Motor Coordination or Function; Developmental Disorder
Interventions: Self-Hypnosis, Ankle Education; Behavioral
Lead sponsor: Ohio University; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Athens, Ohio

Conditions: Premature Birth
Interventions: Movement Training, Social Training; Behavioral
Lead sponsor: Christiana Care Health Services; Other
Eligibility: 6 Weeks to 11 Weeks
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Perinatal Stroke
Interventions: Magnetic Resonance Imaging, Behavioral Assessments, Non invasive Transcranial Magnetic Stimulation; Device · Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 0 Years to 24 Months
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Premature
Interventions: SPEEDI; Behavioral
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: Up to 34 Weeks
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: Not listed
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2004
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Neck Pain
Interventions: Procedure (education and exercise); Other
Lead sponsor: William J. Hanney; Other
Eligibility: 18 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2009
U.S. locations: 9
States / cities: Altamonte Springs, Florida • Jacksonville, Florida • Kissimmee, Florida + 4 more

Conditions: Obesity, Healthy Eating, Physical Activity, Health Knowledge, Attitudes, Practice, Gross Motor Development
Interventions: Center-based Intervention, Home-based Intervention, Active Control; Behavioral
Lead sponsor: The University of Texas at San Antonio; Other
Eligibility: 3 Years to 5 Years
Enrollment: 525 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Autism Spectrum Disorder, Aggression, Irritability
Interventions: Transdermal nicotine, Transdermal placebo; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Weight Gain Prevention, Physical Inactivity
Interventions: Family Fit Condition; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 9 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Preterm Infant, Cerebral Palsy
Interventions: Supporting Play Exploration and Developmental Intervention (SPEEDI); Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: Up to 6 Months
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 2
States / cities: Los Angeles, California • Richmond, Virginia

Conditions: Autism
Interventions: Oxcarbazepine, Placebo/sugar pill; Drug · Other
Lead sponsor: University of Medicine and Dentistry of New Jersey; Other
Eligibility: 5 Years to 17 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Autism Spectrum Disorder, Developmental Disability, Aggression, Self-Injurious Behavior, Challenging Behavior
Interventions: Propranolol; Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 12 Years to 30 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Osteoarthritis, Arthritis
Interventions: Negative Work, Stretching; Other
Lead sponsor: Washington D.C. Veterans Affairs Medical Center; Federal
Eligibility: 50 Years to 70 Years · Male only
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Astigmatism Bilateral, Eyeglasses
Interventions: Spectacle wear support, Spectacles; Behavioral · Device
Lead sponsor: University of Arizona; Other
Eligibility: 12 Months to 35 Months
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Tucson, Arizona

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Motor Development of Children That Have Surgery as Newborns for Complex Congenital Heart Disease

Steppin' Up: Positive Youth Development Program

Fit Families Program for Families of Children With Autism Spectrum Disorder

Longitudinal Study of Neurodegenerative Disorders

Education Program for Caregivers of Children With Gross Motor Delays

Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers With and Without Cerebral Palsy

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Delineation of Sensorimotor Subtypes Underlying Residual Speech Errors

On Track: Monitoring Development of Children With Cerebral Palsy or Gross Motor Delay

Exercise Training in Children With Communication Impairments

Project Hypnos: The Impact of a Brief Hypnosis Intervention on Single-limb Dynamic Balance in People With Chronic Ankle Instability

Development Training in Babies Born Preterm

Baby Brain Recovery Study

Feasibility Study of SPEEDI

Study of Attention Deficit/Hyperactivity Disorder Using Transcranial Magnetic Stimulation

Identify Patients With Neck Pain Likely to Benefit From Education and Exercise

Míranos! Program, a Preschool Obesity Prevention RCT

Nicotinic Cholinergic Modulation as a Novel Treatment Strategy for Aggression Associated With Autism

Family Fit Iterative App Development

Does Timing Matter? Supporting Play, Exploration, and Early Developmental Intervention

Oxcarbazepine Versus Placebo in Childhood Autism

Propranolol for Challenging Behaviors in Autism

Negative Work Exercise for the Treatment of Knee Arthritis

Spectacle Prescribing in Early Childhood