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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:16 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 90 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Multiple Sclerosis Fatigue Clear all

Conditions: Fatigue, Multiple Sclerosis, Sleep Apnea
Interventions: Auto-titration CPAP, Sham-CPAP; Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Multiple Sclerosis
Interventions: L-Histidine, Placebo, Lodosyn; Drug
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 60 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Multiple Sclerosis, Insomnia
Interventions: Telehealth cognitive behavioral therapy for insomnia (tCBT-I), Web-based cognitive behavioral therapy for insomnia (wCBT-I), Treatment as usual (TAU); Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Multiple Sclerosis Fatigue
Interventions: Ketamine, Midazolam; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Multiple Sclerosis
Interventions: Active-Alert Hypnosis, Traditional Hypnosis; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Multiple Sclerosis, Peripheral Neuropathy
Interventions: Meditation instruction and practice; Behavioral
Lead sponsor: The Cleveland Clinic; Other
Eligibility: Not listed
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Progressive Multiple Sclerosis, Fatigue
Interventions: N-acetyl cysteine, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 75 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Multiple Sclerosis
Interventions: Not listed
Lead sponsor: Milap Sandhu; Other
Eligibility: 18 Years and older · Female only
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Multiple Sclerosis, Balance, Fatigue, Eye Movement
Interventions: Vestibular rehabilitation: balance and eye movement exercises; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 60 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Multiple Sclerosis, Fatigue
Interventions: Mitoquinone, Placebo; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Multiple Sclerosis (MS), Fatigue, Physical Inactivity
Interventions: ExerciseRx intervention; Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 106 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: Ocrevus; Drug
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years to 64 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: West Orange, New Jersey

Conditions: Multiple Sclerosis
Interventions: Exercise Training Program, Flexibility Program; Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years to 65 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Multiple Sclerosis, Multiple Sclerosis Fatigue
Interventions: Solriamfetol, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Multiple Sclerosis
Interventions: Transcutaneous electrical nerve stimulation; Device
Lead sponsor: University of Colorado, Boulder; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Multiple Sclerosis, Fatigue
Interventions: Ketamine, Midazolam; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Multiple Sclerosis
Interventions: Multiple Sclerosis patients who have been on Ocrelizumab will undergo cognitive and fatigue assessments; Other
Lead sponsor: Anza Memon; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
Interventions: DPA-714 PET/MRI; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2028
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Multiple Sclerosis
Interventions: 1000mg acetaminophen or placebo; Drug
Lead sponsor: Hunter College of City University of New York; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Multiple Sclerosis
Interventions: AndroGel 1 % Topical Gel, Placebos; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 60 Years · Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 2
States / cities: Los Angeles, California • St Louis, Missouri

Conditions: Multiple Sclerosis
Interventions: Self-management intervention, Education; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: Provigil (modafinil); Drug
Lead sponsor: Institute for Clinical Research; Other
Eligibility: 20 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2003
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Multiple Sclerosis, Fatigue
Interventions: Dalfampridine, Placebo; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 20 Years to 59 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Multiple Sclerosis
Interventions: Cooking Course; Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Portland, Oregon

Search by objective public record fields.

Continuous Positive Airway Pressure (CPAP) for Fatigue in Patients With Multiple Sclerosis (MS) and Obstructive Sleep Apnea (OSA)

Histaminergic Basis of Fatigue in Multiple Sclerosis

Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection

Ketamine for Multiple Sclerosis Fatigue

Waking Hypnosis in the Treatment of MS-related Fatigue

Effects of Meditation on Multiple Sclerosis and Peripheral Neuropathy

A Study of Oxidative Pathways in MS Fatigue

Investigating the Impact of Sex Hormones in Multiple Sclerosis

Vestibular Rehabilitation for Persons With Multiple Sclerosis: Who Benefits the Most? (MSVR3trial)

MitoQ for Fatigue in Multiple Sclerosis

Increasing Physical Activity for Adults With Multiple Sclerosis (MS)

Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI

Feasibility of Remote Exercise Training for Hispanics/Latinos With MS

Solriamfetol for the Treatment of Multiple Sclerosis Fatigue

Reducing Fatigue in People With Multiple Sclerosis by Treatment With TENS

Ketamine for Treatment of MS Fatigue

Assessing the Effects of Ongoing Ocrelizumab (OCR) Therapy on Fatigue and Cognition in Veterans With Multiple Sclerosis

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

Effect of Acetominophen an Gait Fatigue in Multiple Sclerosis

Testosterone for Fatigue in Men With MS

TakeCharge: Telephone Delivered Self-management Intervention for People With Multiple Sclerosis (MS)

Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS

Dalfampridine for Imbalance in Multiple Sclerosis

Rouxbe Pilot for MS