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ClinicalTrials.gov public records Last synced Jul 23, 2026, 9:56 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Muscle Contracture Clear all
Completed No phase listed Observational

Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859

NCT00954746
View directory record Official record
Conditions
Dupuytren's Disease
Interventions
Not listed
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
645 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
23
States / cities
Phoenix, Arizona • Tucson, Arizona • Burbank, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2015 · Synced Jul 23, 2026, 9:56 PM EDT
Not yet recruiting Early Phase 1 Interventional

Collagenase Injection for Contracture Management

NCT07693556
View directory record Official record
Conditions
Contracture
Interventions
Active XIAFLEX Collagenase injection
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 23, 2026, 9:56 PM EDT
Terminated Phase 2 Interventional Results available

Breast Capsular Contracture Following Post-Mastectomy Reconstruction in Women Treated With the Leukotriene Inhibitor Zafirlukast: A Phase II Trial

NCT02950480
View directory record Official record
Conditions
Breast Cancer
Interventions
zafirlukast, Standard of Care (no intervention)
Drug · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 89 Years · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2019 · Synced Jul 23, 2026, 9:56 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture

NCT01226121
View directory record Official record
Conditions
Dupuytren's Disease
Interventions
Clostridial collagenase injectable
Biological
Lead sponsor
Indiana Hand to Shoulder Center
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Indianaplis, Indiana • Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Jul 23, 2026, 9:56 PM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures

NCT01564407
View directory record Official record
Conditions
Restrictive Scar Contracture, Restrictive Hypertrophic Scar, Burn Scar Contractures, Burn Scar
Interventions
ICX-RHY-013
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Jul 23, 2026, 9:56 PM EDT
Terminated Phase 2 Interventional Results available

Pilot Study of Azficel-T for the Treatment of Restrictive Burn Scars

NCT01858753
View directory record Official record
Conditions
Restrictive Burn Scars
Interventions
Autologous fibroblasts, placebo sterile saline
Biological
Lead sponsor
Castle Creek Biosciences, LLC.
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
9
States / cities
Sacramento, California • San Diego, California • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Jul 23, 2026, 9:56 PM EDT
Not yet recruiting Not applicable Interventional

Short-term and Intermediate-term Effects of Self-applied Joint Mobilization Versus Clinician-applied Joint Mobilization in Addition to Exercise in Patients With Knee Osteoarthritis: A Randomized Clinical Trial

NCT07020897
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Clinician-administered joint mobilization, Self-administered joint mobilization, Exercise-based physical therapy
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
45 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Allen, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Jul 23, 2026, 9:56 PM EDT
Completed Phase 3 Interventional Results available

Collagenase in the Treatment of Dupuytrens Disease

NCT00260429
View directory record Official record
Conditions
Dupuytren's Disease
Interventions
collagenase clostridium histolyticum
Biological
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2010 · Synced Jul 23, 2026, 9:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ultrasound B Mode Imaging and Elastography

NCT04607187
View directory record Official record
Conditions
Dupuytren's Contractures
Interventions
Not listed
Lead sponsor
Theresa Bass-Goldman
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Wheaton, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 28, 2020 · Synced Jul 23, 2026, 9:56 PM EDT
Completed No phase listed Observational

CORRECT: COmmunity RegistRy Study Evaluating Dupuytren's Contracture Treatment

NCT01715467
View directory record Official record
Conditions
Dupuytren's Contracture
Interventions
Not listed
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
27
States / cities
Burbank, California • Encinitas, California • La Jolla, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2015 · Synced Jul 23, 2026, 9:56 PM EDT
Completed Not applicable Interventional

A Prospective Trial of Virtual Home Rehabilitation After Burn Injury

NCT03475654
View directory record Official record
Conditions
Burns, Burn Scar, Contracture
Interventions
Technology-assisted rehabilitation, Usual care
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Jul 23, 2026, 9:56 PM EDT
Recruiting Not applicable Interventional

Pilot Test of Caregiver Training Protocol for Brachial Plexus Birth Injury

NCT06623357
View directory record Official record
Conditions
Brachial Plexus Birth Palsy, Erbs Palsy
Interventions
Pilot Training Protocol, Standard Training Protocol
Other
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
St. Petersburg, Florida • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 23, 2026, 9:56 PM EDT
Completed No phase listed Observational

The Relationship of Rehabilitation Therapy Time To The Prevention of Burn Scar Contracture

NCT01161810
View directory record Official record
Conditions
Burns
Interventions
Routine post burn rehabilitation therapy
Other
Lead sponsor
American Burn Association
Other
Eligibility
18 Years to 90 Years
Enrollment
386 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
14
States / cities
Phoenix, Arizona • Orange, California • Sacramento, California + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 3, 2023 · Synced Jul 23, 2026, 9:56 PM EDT
Completed Phase 4 Interventional Results available

MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex

NCT01450397
View directory record Official record
Conditions
Dupuytren's Disease
Interventions
XIAFLEX
Biological
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
35 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jul 23, 2026, 9:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Immediate and 24-hour Effects of HyperVolt, Body Tempering, and Cupping Compared to Stretching on Hamstring Flexibility

NCT05793242
View directory record Official record
Conditions
Hamstring Contractures, Muscle Tightness
Interventions
Hypervolt, Body Tempering, Dry cupping, Static stretching
Device · Other
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 39 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Jul 23, 2026, 9:56 PM EDT
Not listed Not applicable Interventional

Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar Pressure

NCT02233140
View directory record Official record
Conditions
Diabetes, Equinus Contracture of the Ankle
Interventions
Extra-corporeal pulsed-activated therapy or shockwave therapy
Device
Lead sponsor
Temple University
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 26, 2015 · Synced Jul 23, 2026, 9:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Glenohumeral Rotation After Throwing: RCT Comparing the Sleeper Stretch to the 90/90 Hip Lift With Balloon Blow Exercise

NCT03091530
View directory record Official record
Conditions
Internal Rotation Contracture-shoulder
Interventions
Sleeper Stretch, 90/90 Hip Lift with Balloon Blow Exercise
Other
Lead sponsor
Duke University
Other
Eligibility
15 Years to 19 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Jul 23, 2026, 9:56 PM EDT
Completed Phase 2 Interventional Results available

Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules

NCT02193828
View directory record Official record
Conditions
Dupuytren's Disease
Interventions
Collagenase clostridium histolyticum, Placebo
Biological
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
9
States / cities
Tucson, Arizona • Encinitas, California • Greenbrae, California + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2017 · Synced Jul 23, 2026, 9:56 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Joint Range of Motion in Burn Scars

NCT01034813
View directory record Official record
Conditions
Contractures Resulting From Burn Scar Tissue
Interventions
Not listed
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years to 60 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2015 · Synced Jul 23, 2026, 9:56 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery

NCT06806410
View directory record Official record
Conditions
Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation, Dupuytren Contracture, Finger Fracture, Wrist Arthropathy, Distal Radius Fracture
Interventions
Liposomal bupivacaine (LB), Dexamethasone
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Jul 23, 2026, 9:56 PM EDT
Completed Not applicable Interventional

Efficacy of Strength Training in Improving Elbow Range of Motion and Function in Adults With Hemophilia

NCT03842605
View directory record Official record
Conditions
Hemophilia, Elbow Joint Contracture
Interventions
Strength training
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Jul 23, 2026, 9:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Aspen™ Ultrasound System and Aspen Rehabilitation Technique in the Treatment of Capsular Contracture

NCT02840084
View directory record Official record
Conditions
Capsular Contracture of Breast, Grade III
Interventions
Aspen(TM) Ultrasound System
Device
Lead sponsor
Nina Naidu
Individual
Eligibility
22 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Jul 23, 2026, 9:56 PM EDT
Enrolling by invitation Phase 1 Interventional

Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy

NCT06377085
View directory record Official record
Conditions
Cerebral Palsy, Contracture
Interventions
Placebo for the AZA 10mg/m^2, Placebo for the AZA 20mg/m^2, Placebo for the AZA 35mg/m^2, Placebo for the AZA 75mg/m^2, 5-Azacytidine 10mg/m^2, 5-Azacytidine 20mg/m^2, 5-Azacytidine 35mg/m^2, 5-Azacytidine 75mg/m^2
Drug
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
2 Years to 18 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 23, 2026, 9:56 PM EDT
Completed No phase listed Observational

Splinting for Dupuytren's Contracture Release

NCT00575458
View directory record Official record
Conditions
Dupuytren's Disease
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 15, 2010 · Synced Jul 23, 2026, 9:56 PM EDT