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Showing 1–24 of 69 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Muscular Soreness Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Powdered Tart Cherries on Recovery From Repeated Sprints

NCT06122038
View directory record Official record
Conditions
Inflammation, Oxidative Stress, Soreness, Muscle, Muscle Damage
Interventions
Tart Cherry Extract Powder, Placebo
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Pilot Study Comparing the Efficacy and Safety of a New Pain Patch and Placebo in Delayed Onset Muscle Soreness (DOMS)

NCT02602353
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
Loxoprofen Pain Patch, Placebo Patch, No Treatment
Drug
Lead sponsor
Lead Chemical Co., Ltd.
Industry
Eligibility
18 Years to 40 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Omega-3 Fatty Acid Supplementation to Enhance Performance

NCT05924139
View directory record Official record
Conditions
Strength, Body Composition, Muscle Soreness
Interventions
Omega-3 fatty acid, Placebo
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 25 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients

NCT01211717
View directory record Official record
Conditions
Type 2 Diabetes, Healthy Individuals
Interventions
Branched Chained Amino Acids, Cellulose Placebo mix
Dietary Supplement · Other
Lead sponsor
Loma Linda University
Other
Eligibility
20 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2011 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Immune and Recovery Modulating Impact of Probiotic Supplementation After Intense Resistance Exercise

NCT04441840
View directory record Official record
Conditions
Immune Markers, Complete Blood Count (CBC) With Platelet Differentials, Muscle Damage, Muscular Force Production, Countermovement Jump, Muscular Fatigue, Muscular Soreness
Interventions
Active Probiotic Culture, Inactive Probiotic Culture
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Whey Protein Supplements on Markers of Exercise-induced Muscle Damage in Resistance-trained Individuals

NCT05100459
View directory record Official record
Conditions
Muscle Damage, Muscle Soreness
Interventions
Pasture-raised whey protein, Conventional whey protein, Placebo
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Sep 5, 2026, 9:15 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance

NCT06795425
View directory record Official record
Conditions
Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness, Immune Function, Gut Health, Microbiome Analysis, Exercise Performance, Exercise Metabolism
Interventions
Postbiotic Active Lifestyle Blend, Placebo
Dietary Supplement · Other
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mirthful Laughter and Muscle Soreness / Pain

NCT02896075
View directory record Official record
Conditions
Pain
Interventions
30 Minute Comedy Video, 30 Minute Documentary Video
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
20 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Sep 5, 2026, 9:15 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Effects of Liquid IV's Multi-Ingredient Recovery Supplement on Muscle Recovery Following Exercise

NCT07224867
View directory record Official record
Conditions
Muscle Damage, Strength Recovery, Perceived Recovery, Perceived Muscle Soreness, Physical Performance, Muscle Recovery
Interventions
proprietary post workout recovery supplement, Control placebo
Dietary Supplement
Lead sponsor
Applied Science & Performance Institute
Industry
Eligibility
18 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Dosing Interval Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness

NCT02339129
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
SST-0225, Placebo
Drug
Lead sponsor
Strategic Science & Technologies, LLC
Industry
Eligibility
16 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
South Miami, Florida • Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Sep 5, 2026, 9:15 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study to Understand the Analgesic Properties of Topically Applied Menthol When Used in a Marathon.

NCT07565246
View directory record Official record
Conditions
Muscle Soreness
Interventions
Observational
Other
Lead sponsor
Reckitt Benckiser Healthcare (UK) Limited
Industry
Eligibility
18 Years and older
Enrollment
367 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Deerfield, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study Comparing the Efficacy and Safety of Orally Administered Ibuprofen and Placebo in Delayed Onset Muscle Soreness

NCT02113566
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
Acetaminophen 1000mg
Drug
Lead sponsor
Jean Brown Research
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Chronic Study on Body Composition, Training, Performance, and Recovery

NCT04230824
View directory record Official record
Conditions
Damage Muscle, Body Weight Changes, Performance Enhancing Product Use
Interventions
Pre-workout plus and Protein recovery plus, Placebo, 6-week resistance training program
Dietary Supplement · Other
Lead sponsor
Pharmanex
Industry
Eligibility
25 Years to 50 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 12, 2022 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Palmar Cooling on the Human Immune System

NCT07215338
View directory record Official record
Conditions
Human Immune Response
Interventions
Muscle Temperature Control
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Two Different Forms of Marine Oil on Indirect Markers of Muscle Damage and Soreness in Untrained Men

NCT03760757
View directory record Official record
Conditions
Inflammation; Muscle
Interventions
ESPO-572®, PCSO-524®
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lumbosacral Muscle Sensitivity & Pressure Pain Threshold After Kettlebell Swings

NCT05607212
View directory record Official record
Conditions
Muscle Soreness, Muscle Weakness, Muscle Tenderness
Interventions
Kettlebell Swing, Isometric Hold, Control
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 35 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Etodolac-lidocaine Patch in Subjects Experiencing Acute Delayed Onset Muscle Soreness

NCT02695381
View directory record Official record
Conditions
Acute Delayed Onset Muscle Soreness (DOMS)
Interventions
Etodolac-lidocaine topical patch, Placebo
Drug
Lead sponsor
MEDRx USA, Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Sep 11, 2016 · Synced Sep 5, 2026, 9:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pneumatic Compression vs Blood Flow Restriction for Muscle Recovery

NCT06815367
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
Pneumatic Compression, Blood Flow Restriction
Device
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 30 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 5, 2026, 9:15 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

NCT03540602
View directory record Official record
Conditions
Muscle Soreness
Interventions
Tart Cherry, Placebo Oral Capsule [CEBOCAP]
Dietary Supplement · Other
Lead sponsor
Jacksonville University
Other
Eligibility
21 Years to 45 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 29, 2018 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of a Polyherbal Supplement on the Signs and Symptoms of Delayed Onset Muscle Soreness

NCT02157675
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
Polyherbal capsule, Placebo capsule
Dietary Supplement
Lead sponsor
NewChapter, Inc.
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Water Oxygenation and Brain Activity

NCT02688452
View directory record Official record
Conditions
Muscle Damage
Interventions
Control Unmodified Placebo Water, Electrokinetically modified water (EMW)
Dietary Supplement
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2017 · Synced Sep 5, 2026, 9:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Watermelon Juice on Heart Rate Recovery and Post-exercise Muscle Soreness

NCT03380195
View directory record Official record
Conditions
Heart Rate Recovery
Interventions
Watermelon juice, Sport drink, Sugar water, Water
Other
Lead sponsor
San Diego State University
Other
Eligibility
21 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Self-myofascial Release With a Foam Roll Change Pressure Pain Thresholds in Lower Extremity Muscles

NCT02924259
View directory record Official record
Conditions
Myofascial Pain Syndromes
Interventions
The GRID foam roll
Device
Lead sponsor
California State University, Dominguez Hills
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Carson, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2016 · Synced Sep 5, 2026, 9:15 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effects of Riboflavin in Mitigating Muscle Soreness in Ultra-marathon Athletes

NCT05907850
View directory record Official record
Conditions
Muscle Soreness
Interventions
Riboflavin, Placebo
Drug
Lead sponsor
Steven Moore
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Sep 5, 2026, 9:15 AM EDT