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ClinicalTrials.gov public records Last synced Sep 14, 2026, 10:45 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Muscular Weakness Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation

NCT06395506
View directory record Official record
Conditions
Breast Cancer, Breast Cancer Female, Muscle Weakness
Interventions
Creatine
Dietary Supplement
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Effectiveness of Creatine in Preventing Muscle Aching From Cholesterol-Lowering Statin Drugs

NCT00797407
View directory record Official record
Conditions
Hypercholesterolemia, Aches, Cramps, Weakness
Interventions
Creatine
Dietary Supplement
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Wooster, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 24, 2008 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Phase 2 Interventional

Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositis

NCT00033891
View directory record Official record
Conditions
Dermatomyositis, Polymyositis
Interventions
Infliximab
Drug
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 2, 2019 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional

CAPABLE for Frail Dually Eligible Older Adults

NCT01743495
View directory record Official record
Conditions
Muscle Weakness
Interventions
10 home-based functional services sessions over 4 months.
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
281 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Gluteus Maximus Recruitment

NCT02042937
View directory record Official record
Conditions
Muscular Weakness
Interventions
Exercise
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 36 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 3, 2014 · Synced Sep 14, 2026, 10:45 AM EDT
Recruiting Phase 1 Interventional

A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases

NCT06626919
View directory record Official record
Conditions
Muscular Diseases, Neuromuscular Manifestations, Autoimmune, Autoimmune Diseases, Autoimmune Diseases of the Nervous System, Myasthenia Gravis, Muscle Weakness
Interventions
anito-cel, Standard Lymphodepletion regimen
Biological · Drug
Lead sponsor
Arcellx, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
13
States / cities
Los Angeles, California • Orange, California • Palo Alto, California + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Phase 2 Interventional

The Effect of Exercise on Muscle, Function and Cost in VA Nursing Home Residents

NCT00105807
View directory record Official record
Conditions
Muscle Weakness
Interventions
participation in low intensity exercise, participation in art and music activities
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
65 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 14, 2026, 10:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training for People With Disabilities

NCT06441422
View directory record Official record
Conditions
Weakness, Muscle
Interventions
Blood flow restriction training, No blood flow restriction training
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Translating Unique Learning for Incontinence Prevention

NCT01599715
View directory record Official record
Conditions
Urinary Incontinence
Interventions
Instructional DVD, Bladder Health Class
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
55 Years and older · Female only
Enrollment
647 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
2
States / cities
Ann Arbor, Michigan • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Sep 14, 2026, 10:45 AM EDT
Active, not recruiting No phase listed Observational

Measuring Outcomes of Activity in Intensive Care

NCT03115840
View directory record Official record
Conditions
Critical Illness, Sepsis, Mechanical Ventilation, Physical Activity, Disability Physical, Muscle Weakness, Cognitive Impairment
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2030
U.S. locations
2
States / cities
Columbus, Ohio • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Sep 14, 2026, 10:45 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Relationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN)

NCT07009717
View directory record Official record
Conditions
Chemotherapy-induced Peripheral Neuropathy (CIPN), Healthy
Interventions
No intervention (observational study)
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 14, 2026, 10:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Strong Brain Study

NCT02320864
View directory record Official record
Conditions
Osteoarthritis, Sarcopenia
Interventions
Total knee replacement surgery
Procedure
Lead sponsor
University of Florida
Other
Eligibility
60 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms

NCT01032993
View directory record Official record
Conditions
Pain, Weakness, Cramps, Myalgia or Myositis Nos, HMG COA Reductase Inhibitor Adverse Reaction
Interventions
Coenzyme Q10, Placebo
Dietary Supplement · Other
Lead sponsor
Catherine Buettner
Other
Eligibility
21 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2017 · Synced Sep 14, 2026, 10:45 AM EDT
Completed No phase listed Observational

The Adapting Disease Specific Outcome Measures Pilot Trial for Telehealth in Myasthenia Gravis

NCT05917184
View directory record Official record
Conditions
Myasthenia Gravis
Interventions
Telehealth
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
New Haven, Connecticut • Washington D.C., District of Columbia • Chicago, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

EMG Training for Altering Activation Patterns After Stroke

NCT03619772
View directory record Official record
Conditions
Stroke, Weakness, Muscle, Coordination Lack
Interventions
Bilateral, Unilateral
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Sequencing on Outcome Measures

NCT06445491
View directory record Official record
Conditions
Muscle Weakness
Interventions
Control order, Randomized sequence
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 57 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Benefit of CoQ-10 in Patients on Statins

NCT00997269
View directory record Official record
Conditions
Pain, Soreness, Weakness, Fatigue
Interventions
Co-enzyme Q-10, Placebo
Dietary Supplement
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2016 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physical Activity Intervention Tailored for Rural Men

NCT05460637
View directory record Official record
Conditions
Physical Inactivity, Sedentary Behavior, Weak; Muscle
Interventions
No BS just Fitness
Behavioral
Lead sponsor
Jacob Gallagher
Other
Eligibility
18 Years to 80 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Sep 14, 2026, 10:45 AM EDT
Terminated Phase 2 Interventional Results available

A Study to Evaluate ASP0367 in Participants With Primary Mitochondrial Myopathy

NCT04641962
View directory record Official record
Conditions
Primary Mitochondrial Myopathy
Interventions
Bocidelpar, Placebo
Drug
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
11
States / cities
La Jolla, California • Stanford, California • Aurora, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 14, 2026, 10:45 AM EDT
Active, not recruiting Not applicable Interventional

Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes

NCT02509520
View directory record Official record
Conditions
Muscle Weakness, Critical Illness, Sarcopenia
Interventions
MPR and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
Dietary Supplement
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
45 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Diagnosing Intensive Care Unit (ICU) Acquired Weakness

NCT04166630
View directory record Official record
Conditions
ICU Acquired Weakness
Interventions
Clinical Electrical Stimulator
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Sep 14, 2026, 10:45 AM EDT
Not listed Not applicable Interventional

Early Rehabilitation Using Functional Electrical Stimulation Assisted Supine Cycling in the Intensive Care Unit

NCT03554811
View directory record Official record
Conditions
ICU Acquired Weakness
Interventions
Functional electrical stimulation assisted supine cycling (FESC), Conventional early exercise and mobility interventions
Device · Other
Lead sponsor
Community Health System
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2021 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Phase 1 Interventional

Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After Anterior Cruciate Ligament Reconstruction

NCT04504344
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction, Quadriceps Muscle Weakness, Transcranial Direct Current Stimulation
Interventions
Anodal transcranial direct current stimulation (tDCS) - Soterix Medical Inc, 1x1 tDCS (conventional)
Device
Lead sponsor
Arcadia University
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Glenside, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Sep 14, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Controlled Trial Comparing Traditional Pelvic Floor Rehabilitation to Pilates in Increasing Pelvic Muscles Strength.

NCT00549458
View directory record Official record
Conditions
Muscle Weakness
Interventions
Pilates, Pelvic muscle rehabilitation therapy
Behavioral · Procedure
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2009 · Synced Sep 14, 2026, 10:45 AM EDT