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ClinicalTrials.gov public records Last synced Oct 24, 2026, 2:41 PM EDT

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Showing 1–24 of 79 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Myalgic Encephalomyelitis Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Hyporeactivity and Gulf War Illness

NCT00100412
View directory record Official record
Conditions
Gulf War Syndrome, Chronic Fatigue Syndrome, Post-Traumatic Stress Disorder
Interventions
Graded dobutamine infusions, Graded phenylephrine injections, Psychosocial challenge involving socioevaluative public speaking
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2002
U.S. locations
1
States / cities
East Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Autonomic Nervous System and Chronic Fatigue Syndrome

NCT00580619
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Orthostatic Intolerance, Postural Tachycardia Syndrome
Interventions
Autonomic Function Testing, Saline infusions, L-NMMA trimethaphan, methyldopa
Other · Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 65 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 18, 2017 · Synced Oct 24, 2026, 2:41 PM EDT
Completed No phase listed Observational

Patient-Centered Assessment of Symptoms and Outcomes

NCT03952624
View directory record Official record
Conditions
Fatigue, Cancer, CFS, ME/CFS, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Lupus, Systemic Lupus Erthematosus, Sjogrens
Interventions
Not listed
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 120 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Not applicable Interventional Results available

Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process

NCT01650636
View directory record Official record
Conditions
Chronic Fatigue Syndrome
Interventions
Patient-Partner Videotelephone-delivered Health Information (PP-T-HI), Patient-Partner Videotelephone-delivered Cognitive Behavioral Stress Management intervention (PP-T-CBSM)
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
21 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Oct 24, 2026, 2:41 PM EDT
Not listed No phase listed Observational

Exercise-related Post-exertional Malaise

NCT03331419
View directory record Official record
Conditions
Chronic Fatigue Syndrome
Interventions
Exercise test
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 24, 2026, 2:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome

NCT00810329
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Illness, Multiple Chemical Sensitivity, Interstitial Cystitis, Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
Georgetown University
Other
Eligibility
21 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2014 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Not applicable Interventional

Treatment of CFS & Fibromyalgia With Recovery Factors

NCT04381793
View directory record Official record
Conditions
Fibromyalgia, Chronic Fatigue Syndrome
Interventions
Recovery Factors
Dietary Supplement
Lead sponsor
Practitioners Alliance Network
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Kailua, Hawaii
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 24, 2026, 2:41 PM EDT
Active, not recruiting Not applicable Interventional

tVNS in Long COVID-19

NCT06585254
View directory record Official record
Conditions
Long COVID, Chronic Fatigue Syndrome
Interventions
Transcutaneous vagus nerve stimulator
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
21 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 24, 2026, 2:41 PM EDT
Recruiting No phase listed Observational

A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS

NCT07551999
View directory record Official record
Conditions
Encephalomyelitis, Chronic Fatigue Syndrome
Interventions
Voice Recording
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Oct 24, 2026, 2:41 PM EDT
Enrolling by invitation No phase listed Observational

Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions

NCT06257420
View directory record Official record
Conditions
Myalgic Encephalomyelitis, Long-COVID
Interventions
Rapamycin
Drug
Lead sponsor
Simmaron Research Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
5
States / cities
Palo Alto, California • Rochester, Minnesota • Incline Village, Nevada + 2 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 24, 2026, 2:41 PM EDT
Terminated Phase 4 Interventional Results available

Use of Xyrem to Improve Sleep in Chronic Fatigue Syndrome

NCT00498485
View directory record Official record
Conditions
Chronic Fatigue Syndrome
Interventions
Placebo, Sodium Oxybate
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
21 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated May 19, 2016 · Synced Oct 24, 2026, 2:41 PM EDT
Not yet recruiting Not applicable Interventional

Fareon Open Label Device Clinical Trial

NCT07600320
View directory record Official record
Conditions
Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
Interventions
Fareon device
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
16 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Not applicable Interventional

Traditional African Healing Ceremony in a U.S. Population

NCT01873482
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Anxiety, Depression, Cancer
Interventions
Movement to rhythm
Behavioral
Lead sponsor
Duke University
Other
Eligibility
25 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 3, 2014 · Synced Oct 24, 2026, 2:41 PM EDT
Not listed No phase listed Observational

Discovering Trends in Chronic Fatigue Syndrome Patients' Clinical Study Experiences

NCT05967494
View directory record Official record
Conditions
Chronic Fatigue Syndrome
Interventions
Not listed
Lead sponsor
Power Life Sciences Inc.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Oct 24, 2026, 2:41 PM EDT
Not listed Not applicable Interventional

Hydrogen Water Dosing Study for ME/CFS

NCT06227273
View directory record Official record
Conditions
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Interventions
Hydrogen water
Dietary Supplement
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jan 26, 2024 · Synced Oct 24, 2026, 2:41 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

NCT03759522
View directory record Official record
Conditions
Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
Interventions
DPA-714 PET/MRI
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Trial of Solriamfetol in the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

NCT04622293
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Interventions
Solriamfetol Oral Tablet [Sunosi], Placebo
Drug
Lead sponsor
Rochester Center for Behavioral Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Rochester Hills, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 24, 2026, 2:41 PM EDT
Not listed No phase listed Observational

Genetics of Fibromyalgia

NCT00071162
View directory record Official record
Conditions
Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome, Depression
Interventions
Not listed
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
12 Years and older
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1999
U.S. locations
4
States / cities
Peoria, Illinois • Cincinnati, Ohio • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2009 · Synced Oct 24, 2026, 2:41 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Whole Body Hyperthermia Registry Study

NCT02174003
View directory record Official record
Conditions
Depression, Anxiety, PTSD, Fibromyalgia, Chronic Fatigue Syndrome
Interventions
High intensity whole-body infrared heating
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Not applicable Interventional

Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans

NCT02075489
View directory record Official record
Conditions
Persian Gulf Syndrome, Chronic Fatigue Syndrome
Interventions
Acupressure treatment., Reiki
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 10, 2017 · Synced Oct 24, 2026, 2:41 PM EDT
Active, not recruiting Phase 2 Interventional

Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

NCT04542161
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Interventions
NAC 900mg/day, NAC 3600mg/day, NAC 0mg/day (Placebo)
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
21 Years to 60 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Not applicable Interventional

A Pilot Study of Amygdala Retraining Program in Patients With Chronic Fatigue Syndrome, Chronic Fatigue and Fibromyalgia

NCT01046370
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Chronic Fatigue, Fibromyalgia
Interventions
Amygdala Retraining Program
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 59 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 3, 2012 · Synced Oct 24, 2026, 2:41 PM EDT
Completed Phase 2 Interventional Results available

Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain

NCT00524420
View directory record Official record
Conditions
Fibromyalgia, Chronic Pain, Depression
Interventions
rTMS, Sham rTMS
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 23, 2013 · Synced Oct 24, 2026, 2:41 PM EDT
Recruiting Phase 2 Interventional

The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

NCT06211062
View directory record Official record
Conditions
ME/CFS, IBS - Irritable Bowel Syndrome
Interventions
Floradapt Intensive GI, Placebo
Drug · Other
Lead sponsor
Nova Southeastern University
Other
Eligibility
45 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 24, 2026, 2:41 PM EDT