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ClinicalTrials.gov public records Last synced Oct 25, 2026, 2:22 AM EDT

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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Myofascial Dysfunction Clear all
Terminated Not applicable Interventional Results available

Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain

NCT00716807
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome, Burning Mouth Syndrome
Interventions
nalbuphine plus naloxone, nalbuphine plus placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 20, 2016 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional

Device for Alleviating Temporomandibular Joint (TMJ) Pain

NCT07624539
View directory record Official record
Conditions
Temporomandibular Joint Disorders, Facial Pain, Temporomandibular Joint Dysfunction Syndrome
Interventions
Treatment with BTL-043
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Steamboat Springs, Colorado • Leesburg, Florida • Ocala, Florida
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 25, 2026, 2:22 AM EDT
Not yet recruiting Not applicable Interventional

Effects of Core Strengthening Exercises for Treating TMD

NCT07226505
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction, TMD, TMJ Internal Derangement, Myofascial Pain
Interventions
Experimental: Group 1: Core Strengthening, Group 2: Standard TMD PT
Behavioral
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 25, 2026, 2:22 AM EDT
Not yet recruiting Not applicable Interventional

Measuring Pelvic Floor Muscle Fitness Before and After Treatment

NCT07605598
View directory record Official record
Conditions
Myofacial Pain, Pelvic Pain, Myofascial Pelvic Pain, Chronic Pelvic Pain
Interventions
Near Infrared Imaging
Diagnostic Test
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain and Neck Dysfunction Following Dry Needling With and Without Intramuscular Electrical Stimulus.

NCT04057781
View directory record Official record
Conditions
Neck Pain, Shoulder Pain, Myofascial Pain
Interventions
Dry Needling (DN), Dry needling with Intramuscular electrical stimulation (DNES)
Procedure
Lead sponsor
University of Mary Hardin-Baylor
Other
Eligibility
18 Years to 59 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Belton, Texas
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Oct 25, 2026, 2:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time

NCT00042276
View directory record Official record
Conditions
Neck Pain
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
21 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 25, 2026, 2:22 AM EDT
Recruiting Phase 2 Interventional

Myofascial Dysfunction in Post Stroke Shoulder Pain

NCT06718413
View directory record Official record
Conditions
Stroke
Interventions
hyaluronidase plus saline, saline
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 25, 2026, 2:22 AM EDT
Completed No phase listed Observational

Pelvic Pain in Women With Endometriosis

NCT00073801
View directory record Official record
Conditions
Endometriosis, Chronic Pelvic Pain
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 50 Years · Female only
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 25, 2026, 2:22 AM EDT
Withdrawn Phase 1 Interventional

Botox for Treatment of TMJ Disorder With Bruxism

NCT02202070
View directory record Official record
Conditions
Temporomandibular Joint Disorders, Bruxism, Temporomandibular Joint Dysfunction Syndrome, Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint
Interventions
onabotulinumtoxinA
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional

Brief Treatment for Temporomandibular Pain

NCT00067366
View directory record Official record
Conditions
Temporomandibular Joint Syndrome, Myofascial Pain Dysfunction Syndrome, Orofacial Pain
Interventions
Cognitive-Behavioral treatment, Attention and lifestyle counseling
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 1, 2017 · Synced Oct 25, 2026, 2:22 AM EDT
Withdrawn Not applicable Interventional

A Study Examining the Use of Vaginal Nifedipine With Pelvic Floor Physical Therapy for Levator Myalgia and Pelvic Pain

NCT01586286
View directory record Official record
Conditions
Levator Ani Syndrome
Interventions
Nifedipine, Placebo Ointment Base
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Oct 25, 2026, 2:22 AM EDT
Not listed Phase 1 Interventional

Effects of Masseter Manual Therapy on Temporomandibular Dysfunction

NCT00870922
View directory record Official record
Conditions
Temporomandibular Joint, Temporomandibular Joint Dysfunction Syndrome, Temporomandibular Joint Disorder
Interventions
Active release techniques
Procedure
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 27, 2009 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional

Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia

NCT02892994
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome
Interventions
ultrasound
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older · Female only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Oct 25, 2026, 2:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Feasibility Testing of a New Way to Support the Jaw During 3rd Molar Extractions

NCT03512769
View directory record Official record
Conditions
Impacted Third Molar Tooth, Temporomandibular Joint Dysfunction Syndrome
Interventions
Restful Jaw Device
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 24 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional Results available

Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia: Randomized Single Blinded Investigational Trial

NCT02295644
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome
Interventions
Ultrasound Sonicator 740
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tailored Self-Management of Temporomandibular Disorders (TMD) Using Health Information Technology

NCT03036215
View directory record Official record
Conditions
Temporomandibular Joint Dysfunction Syndrome
Interventions
PACT Experimental Arm
Behavioral
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tissue Changes Following Thoracic Myofascial Release

NCT06651671
View directory record Official record
Conditions
Myofascial Dysfunction, Myofascial Release
Interventions
Myofascial release, Sham (No Treatment)
Procedure
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Stratford, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 22, 2024 · Synced Oct 25, 2026, 2:22 AM EDT
Terminated Phase 2 Interventional Results available

Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)

NCT05162027
View directory record Official record
Conditions
Temporomandibular Disorders
Interventions
Erenumab-Aooe 70 MG in 1 mL Prefilled Syringe, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 25, 2026, 2:22 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Photobiomodulation for Myofascial Pelvic Pain

NCT05926752
View directory record Official record
Conditions
Pelvic Pain, Levator Ani Syndrome, Spastic Pelvic Floor Syndrome, Chronic Pelvic Pain Syndrome, Myalgia of Pelvic Floor
Interventions
SoLá therapy, Pelvic floor physical therapy
Device · Other
Lead sponsor
Orlando VA Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 25, 2026, 2:22 AM EDT
Recruiting Not applicable Interventional

Temporomandibular Joint (TMJ) Positioning Accuracy and Efficiency Using a Dental Compass.

NCT06619574
View directory record Official record
Conditions
Temporomandibular Joint Syndrome
Interventions
3D Analysis Group, Manual Analysis Cohort
Device · Other
Lead sponsor
Dr. Dean Reeves Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Gainesville, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 25, 2026, 2:22 AM EDT
Completed Not applicable Interventional Results available

Quantifying Myofascial Dysfunction in Post-Stroke Pain

NCT05762679
View directory record Official record
Conditions
Myofascial Dysfunction
Interventions
Imaging
Diagnostic Test
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Oct 25, 2026, 2:22 AM EDT