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ClinicalTrials.gov public records Last synced Nov 14, 2026, 6:20 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 206 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: NAC Clear all

Conditions: Autistic Disorder, Seizures, Irritability
Interventions: N-Acetyl Cysteine (NAC); Drug
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: 6 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Mild Depression
Interventions: N-acetylcysteine, Mindfulness-based cognitive therapy, Placebo, Sham mindfulness-based intervention; Drug · Behavioral
Lead sponsor: University of Cincinnati; Other
Eligibility: 15 Years to 24 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Autistic Disorder
Interventions: N-Acetyl Cysteine, Placebo - sugar pill; Drug · Other
Lead sponsor: Stanford University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Stanford, California

Conditions: Nicotine Dependence, Smoking
Interventions: N-acetylcysteine (NAC), Placebo; Drug · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 114 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Asthma
Interventions: N-acetylcysteine; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 80 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Interventions: NAC 900mg/day, NAC 3600mg/day, NAC 0mg/day (Placebo); Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Self-Harm, Depression, Suicide
Interventions: N-acetyl cysteine, Placebo oral tablet; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 16 Years to 24 Years · Female only
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Transposition of Great Vessels, Congenital Heart Disease
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: University of Michigan; Other
Eligibility: Up to 3 Months
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Interventions: Medical Management Counseling, N-acetylcysteine, Placebo; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Breast Cancer, Ductal Carcinoma
Interventions: Nipple-Sparing Mastectomy, Breast Reconstruction, Axillary Surgery, Prophylactic Nipple-Areolar Complex RT; Procedure · Radiation
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older · Female only
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2026
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Borderline Personality Disorder, Self-Injurious Behavior
Interventions: N-Acetylcysteine, placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cannabis Use Disorder
Interventions: N-acetyl cysteine, Placebo oral capsule; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 14 Years to 21 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Sickle Cell Disease, Sickle Cell Anemia
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Bloodworks; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Niemann-Pick Disease, Type C
Interventions: N-Acetyl Cysteine; Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 12 Months and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Neuroectodermal Tumors, Primitive, Liver Neoplasms, Osteosarcoma, Other Childhood Cancers Using Cisplatin-based Regimens
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: 1 Year to 21 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Hysterectomy
Interventions: IV N-acetylcysteine, IV Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: NAC
Interventions: N-acetylcysteine NAC; Drug
Lead sponsor: Lindner Center of HOPE; Other
Eligibility: 18 Years to 65 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Mason, Ohio

Conditions: Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
Interventions: N-Acetyl cysteine, Placebo comparator, Cognitive behavioral therapy (CBT); Drug · Other · Behavioral
Lead sponsor: Ellen Herbst; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Obesity, Hyperlipidemia, Insulin Resistance, Hypertension
Interventions: Glutathione, N-Acetylcysteine, Placebo; Dietary Supplement · Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Stanford, California

Conditions: Carpal Tunnel Surgery, Trigger Finger Disorder, De Quervain Syndrome, Guyon's Canal, Dupuytren Contracture, Morton Neuroma, Tarsal Tunnel Syndrome, Plantar Fasciopathy, Peroneal Nerve Entrapment
Interventions: NAC, NAC 0mg/day (Placebo); Drug
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Radiocontrast Nephropathy
Interventions: N-Acetylcysteine (NAC), 0.9% Sodium-chloride; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 120 Years
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: End-Stage Renal Disease, Dialysis, Hemodialysis
Interventions: N-acetylcysteine, placebo; Dietary Supplement
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Cystic Fibrosis
Interventions: N-acetylcysteine (NAC), Placebo; Drug
Lead sponsor: Stanford University; Other
Eligibility: 7 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 11
States / cities: Birmingham, Alabama • Stanford, California • Denver, Colorado + 8 more

Conditions: Acute Liver Failure, Hepatic Encephalopathy
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: Up to 18 Years
Enrollment: 184 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2010
U.S. locations: 17
States / cities: San Francisco, California • Denver, Colorado • Atlanta, Georgia + 13 more

Search by objective public record fields.

Treatment Resistant Epilepsy and N-Acetyl Cysteine

Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth

A Study of N-Acetyl Cysteine in Children With Autism

N-acetylcysteine for Tobacco Use Disorder

Inpatient Clinical Trial of NAC

Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents

N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)

N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI

Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction

N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD

N-Acetylcysteine for Youth Cannabis Use Disorder

A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease

Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine

NAC to Prevent Cisplatin-induced Hearing Loss

NAC vs Placebo on Opioid Use for Hysterectomy

N-acetylcysteine in Bulimia Nervosa

N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use

Effects of Glutathione (an Antioxidant) and N-Acetylcysteine on Inflammation

NAC-REPAIR for Post-surgical Pain

N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients

Effects of N-acetylcysteine on Muscle Fatigue in Hemodialysis

NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients

N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure