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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:43 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–206 of 206 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: NAC Clear all

Conditions: Choreatic Disorder
Interventions: Not listed
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: Not listed
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2003
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Autism Spectrum Disorder
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Stanford University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2029
U.S. locations: 1
States / cities: Stanford, California

Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: N-acetyl cysteine then Placebo, Placebo then N-acetyl cysteine; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 40 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Chronic Kidney Disease
Interventions: N-acetylcysteine; Drug
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 89 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Gambling, Tobacco Use Disorder
Interventions: N Acetyl Cysteine, Sugar Pill; Drug · Other
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 75 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: New Haven, Connecticut • Minneapolis, Minnesota

Conditions: Ulcerative Colitis
Interventions: mesalamine, ALTH12-1:4, ALTH12-2:4; Drug
Lead sponsor: Altheus Therapeutics, Inc.; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Acute Liver Failure, Fulminant Hepatic Failure
Interventions: N-acetylcysteine; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 255 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2016
U.S. locations: 21
States / cities: Birmingham, Alabama • Los Angeles, California • Sacramento, California + 15 more

Conditions: Tourettes Syndrome, Tic
Interventions: N-Acetylcysteine (NAC), Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 8 Years to 17 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Hearing Loss, Sensorineural Hearing Loss, Noise-Induced Hearing Loss
Interventions: HPN-07, NAC, Placebo; Drug
Lead sponsor: Otologic Pharmaceutics, Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Covid19
Interventions: Glycine, N-acetylcysteine, Alanine; Dietary Supplement
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 55 Years to 85 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Diabetic Nephropathies, Proteinuria, Oxidative Stress
Interventions: N-acetylcysteine, silibin, high-dose silibin, N-acetylcysteine placebo, silibin placebo; Dietary Supplement
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 70 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Surgery
Interventions: Dose Response Curve Placebo, Dose Response Curve N-acetylcysteine 50 mg/kg, Dose Response Curve N-acetylcysteine 100 mg/kg, Dose Response Curve N-acetylcysteine 150 mg/kg, Opioid Reduction with Optimal N-acetylcysteine Dose, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Thoracic Surgery, Atrial Fibrillation in High Risk Patients
Interventions: Amiodarone, N-Acetylcysteine, Placebo; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 184 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 9
States / cities: St Louis, Missouri • Basking Ridge, New Jersey • Middletown, New Jersey + 6 more

Conditions: Obsessive-Compulsive Disorder
Interventions: N-Acetylcysteine, Placebo; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 8 Years to 17 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

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Heart and Skeletal Muscle Problems in Neuroacanthocytosis

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-dose

Inhaled NAC in Treatment of IPF

The Effect of Administration on N-Acetylcysteine on Serum Creatinine Levels in Patients With Chronic Kidney Disease

N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers

Study of the Safety and Tolerability of ALTH12 Versus Mesalamine Enema in Subjects With Left-Sided Ulcerative Colitis

Study of N-Acetylcysteine in Acute Liver Failure (ALF)

N-acetylcysteine (NAC) for Children With Tourette Syndrome

Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC

Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19

N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy

A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.

Amiodarone and N-Acetylcysteine or Amiodarone Alone for Preventing Atrial Fibrillation After Thoracic Surgery

N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder