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ClinicalTrials.gov public records Last synced May 22, 2026, 2:48 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: NYHA Class III Heart Failure Clear all
Enrolling by invitation No phase listed Observational
View directory record Official record
Conditions
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Interventions
CardioMEMS HF System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
2,500 participants
Timeline
2022 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced May 22, 2026, 2:48 AM EDT
Recruiting Phase 2Phase 3 Interventional
View directory record Official record
Conditions
Heart Failure NYHA Class III
Interventions
BaroStim
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Riverhead, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced May 22, 2026, 2:48 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Tricuspid Regurgitation, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Interventions
Left ventricular assist device (LVAD), Tricuspid Valve Repair (TVR)
Device · Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced May 22, 2026, 2:48 AM EDT
Active, not recruiting Phase 1 Interventional
View directory record Official record
Conditions
Congestive Heart Failure, Heart Failure, Heart Disease, Ischemic, Cardiovascular Diseases, Heart Failure, Systolic, Heart Failure，Congestive, Heart Arrhythmia, Heart Failure, Diastolic, Heart; Complications
Interventions
3 x 10e13vg AB-1002
Biological
Lead sponsor
AskBio Inc
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
4
States / cities
Minneapolis, Minnesota • Cincinnati, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced May 22, 2026, 2:48 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Heart Failure, Heart Failure NYHA Class I, Heart Failure NYHA Class II, Heart Failure NYHA Class III
Interventions
PP-MI Intervention, MI-alone Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced May 22, 2026, 2:48 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Interventions
intravascular ventricular assist system (iVAS)
Device
Lead sponsor
NuPulseCV
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
18
States / cities
Washington D.C., District of Columbia • Orlando, Florida • Chicago, Illinois + 14 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced May 22, 2026, 2:48 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Heart Failure and Reduced Ejection Fraction, NYHA Class III Heart Failure
Interventions
Cardiac Contractility Modulation (CCM)
Device
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
4,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
Marlton, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced May 22, 2026, 2:48 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Interventions
High-intensity IMT plus walking, Low-intensity IMT plus walking
Behavioral
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 90 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced May 22, 2026, 2:48 AM EDT
Terminated Phase 2 Interventional
View directory record Official record
Conditions
Heart Failure, Congestive
Interventions
ZP120, I.v. catherization, 6-minutes walk performance, Dyspnea severity assessment, Blood sampling for laboratory tests, ECG, Physical examination
Drug · Procedure · Behavioral
Lead sponsor
Zealand Pharma
Industry
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
22
States / cities
Los Angeles, California • San Diego, California • San Francisco, California + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2007 · Synced May 22, 2026, 2:48 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class I
Interventions
Computerized Cognitive Training with Brain HQ, Computerized Crossword Puzzles
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced May 22, 2026, 2:48 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l), Reduced Left Ventricle Ejection Fraction (<50%), Symptoms of Heart Failure (NYHA Class II-III)
Interventions
Cardiopulmonary exercise test, Echocardiogram
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 110 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced May 22, 2026, 2:48 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
MCC-135, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
53
States / cities
Phoenix, Arizona • Tucson, Arizona • Carmichael, California + 47 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced May 22, 2026, 2:48 AM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Heart Failure, Heart Failure NYHA Class II, Heart Failure NYHA Class III
Interventions
Barostim System, Usual care medical management
Device · Other
Lead sponsor
CVRx, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2033
U.S. locations
2
States / cities
Tampa, Florida • Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced May 22, 2026, 2:48 AM EDT
Active, not recruiting Phase 2 Interventional
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
AB-1002
Drug
Lead sponsor
AskBio Inc
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
37
States / cities
Birmingham, Alabama • Tucson, Arizona • Irvine, California + 31 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced May 22, 2026, 2:48 AM EDT
Active, not recruiting No phase listed Observational
View directory record Official record
Conditions
Heart Failure
Interventions
OPTIMIZER Smart System
Device
Lead sponsor
Impulse Dynamics
Industry
Eligibility
18 Years and older
Enrollment
620 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
90
States / cities
Mesa, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 69 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced May 22, 2026, 2:48 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Heart Failure, Congestive
Interventions
GSK716155, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
21 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
12
States / cities
Savannah, Georgia • Metairie, Louisiana • Auburn, Maine + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2017 · Synced May 22, 2026, 2:48 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional
View directory record Official record
Conditions
Heart Failure
Interventions
Thyroid hormone T3, Control Group
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced May 22, 2026, 2:48 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Heart Failure (NYHA Class III and Ambulatory IV)
Interventions
SonR automatic optimization feature turned ON ("AV+VV").
Device
Lead sponsor
MicroPort CRM
Industry
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced May 22, 2026, 2:48 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Heart Failure NYHA Class III, Heart Failure
Interventions
Cordella PA Sensor System, Standard of Care Pharmacologic Therapy
Device · Drug
Lead sponsor
Endotronix, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2,150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Naperville, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced May 22, 2026, 2:48 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy, Idiopathic Pulmonary Fibrosis, Other Interstitial Lung Disease Without Curative Therapy, Congestive Heart Failure, NYHA Class IV or NYHA Class III Plus 1 Hospitalization in the Past Year, Malignancy, Any Stage 3B or 4 Solid Tumor
Interventions
Comfort Default AD forms, Life Extension Default AD forms, Standard Default AD forms
Other
Lead sponsor
Corporal Michael J. Crescenz VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 29, 2015 · Synced May 22, 2026, 2:48 AM EDT
Active, not recruiting Not applicable Interventional Results available
View directory record Official record
Conditions
Heart Failure NYHA Class III
Interventions
Cordella™ Pulmonary Artery Sensor System
Device
Lead sponsor
Endotronix, Inc.
Industry
Eligibility
18 Years and older
Enrollment
738 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
70
States / cities
Birmingham, Alabama • Huntsville, Alabama • Phoenix, Arizona + 57 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2025 · Synced May 22, 2026, 2:48 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
NYHA Class III Heart Failure
Interventions
CardioMEMS HF Pressure Measurement System
Device
Lead sponsor
CardioMEMS
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
4
States / cities
Atlanta, Georgia • Columbus, Ohio • Oklahoma City, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2015 · Synced May 22, 2026, 2:48 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
No Intervention
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
21
States / cities
Birmingham, Alabama • Beverly Hills, California • Aurora, Colorado + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced May 22, 2026, 2:48 AM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Congestive Heart Failure(CHF)
Interventions
Hawthorn supplement, Ketones, Placebo Control
Dietary Supplement · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced May 22, 2026, 2:48 AM EDT