Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure
Public ClinicalTrials.gov record NCT05598333. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Adaptive, Double-blinded, Placebo Controlled, Randomized, Multi-center Trial to Evaluate the Efficacy, Safety and Tolerability of Intracoronary Infusion of AB-1002 in Adult Subjects With New York Heart Association (NYHA) Class III Heart Failure and Non-ischemic Cardiomyopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single dose of AB-1002, administered via antegrade intracoronary artery infusion, in males and females age \>18 years with non-ischemic cardiomyopathy and NYHA Class III symptoms of HF. Subjects will be randomized into one of three treatment groups in a 1:1:1
Study identification
- NCT ID
- NCT05598333
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 150 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 20, 2023 (Actual)
- Primary completion
- Oct 31, 2026 (Estimated)
- Completion
- Dec 31, 2030 (Estimated)
- Last update posted
- Dec 3, 2025
2023 – 2030
United States locations
- U.S. sites
- 37
- U.S. states
- 22
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiology P.C. Birmingham | Birmingham | Alabama | 35211 | — |
| University of Arizona Sarvor Heart Center | Tucson | Arizona | 85724 | — |
| University of California Irvine Medical Center | Irvine | California | 92697 | — |
| University of California San Diego | La Jolla | California | 92093 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Baycare Medical Group | Clearwater | Florida | 33756 | — |
| University of Miami | Coral Gables | Florida | 33146 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Loyola Medicine Burr Ridge | Oakbrook Terrace | Illinois | 60181 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center (KUMC) | Kansas City | Kansas | 66160 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic - Minnesota | Rochester | Minnesota | 55905 | — |
| Aurora Saint Luke's Health System | Kansas City | Missouri | 64111 | — |
| St. Louis University | St Louis | Missouri | 63117 | — |
| Renown Health | Reno | Nevada | 89502 | — |
| Morristown Medical Center - Cardiology | Morristown | New Jersey | 07962 | — |
| Mt. Sinai New York | New York | New York | 10029 | — |
| Stony Brook | Stony Brook | New York | 11794 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| The Christ Hospital / The Linder Center for Research | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| LVH Cardiology | Allentown | Pennsylvania | 18103 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Medical University of South Carolina (MUSC) Medical Center | Charleston | South Carolina | 29425 | — |
| Stern Cardiovascular | Germantown | Tennessee | 38138 | — |
| Baylor Scott & White Advanced Heart Failure Clinic - Dallas | Dallas | Texas | 75246 | — |
| Baylor College of Medicine (BCM) - Baylor Heart Clinic | Houston | Texas | 77030 | — |
| Houston Methodist Debakey Cardiology Associates | Houston | Texas | 77030 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05598333, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 3, 2025 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05598333 live on ClinicalTrials.gov.