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ClinicalTrials.gov public records Last synced Oct 25, 2026, 9:23 PM EDT

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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Nasolabial Fold Clear all
Completed Phase 3 Interventional Accepts healthy volunteers

PREVELLE Shape (CX002) Dermal Filler Protocol

NCT00764257
View directory record Official record
Conditions
Correction of Nasolabial Folds and Lip Augmentation
Interventions
PREVELLE Shape, Restylane
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2011 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Phase 4 Interventional Results available

Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study)

NCT02176356
View directory record Official record
Conditions
Facial Rhytides, Crow's Feet Lines, Glabellar Lines, Nasolabial Fold
Interventions
onabotulinumtoxinA, bimatoprost ophthalmic solution 0.03%, JUVÉDERM® ULTRA XC, JUVÉDERM® ULTRA PLUS XC, JUVÉDERM® VOLUMA® XC
Biological · Drug · Device
Lead sponsor
Allergan
Industry
Eligibility
35 Years to 65 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Oct 25, 2026, 9:23 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers

NCT01492140
View directory record Official record
Conditions
Correction of Nasolabial Folds
Interventions
Subdermal Injection, Artiste Assisted Injection System
Procedure · Device
Lead sponsor
TKL Research, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
3
States / cities
New York, New York • Houston, Texas • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 14, 2011 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness of Aquamid as Compared to Restylane for the Aesthetic Treatment of Nasolabial Folds

NCT00407914
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Aquamid, Restylane
Device
Lead sponsor
Contura
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2009 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers

NCT02647853
View directory record Official record
Conditions
Nasolabial Folds, Lipoatrophy, Lipodystrophy
Interventions
TAT4 Gel concentration A, TAT4 Gel concentration B, Placebo
Drug
Lead sponsor
Topokine Therapeutics, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Cypress, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2016 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Evaluate Safety and Efficacy of Revanesse® Ultra + vs Revanesse® Ultra for Correction of NLF

NCT02991040
View directory record Official record
Conditions
Nasolabial Fold Correction
Interventions
Revanesse Ultra+ (with lidocaine), Revanesse Ultra
Device
Lead sponsor
Prollenium Medical Technologies Inc.
Industry
Eligibility
22 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Pain With Belotero® Balance With Integral Lidocaine for Correction of the Nasolabial Folds

NCT03319719
View directory record Official record
Conditions
Correction of Moderate to Severe Nasolabial Folds
Interventions
Belotero® Balance with integral lidocaine, Belotero® Balance
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Nashville, Tennessee • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2019 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Effectiveness of Sculptra Aesthetic for Correction of Nasolabial Folds.

NCT03780244
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Sculptra Aesthetic 8ml, Sculptra Aesthetic 5ml
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
5
States / cities
Scottsdale, Arizona • Solana Beach, California • Bradenton, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 25, 2026, 9:23 PM EDT
Not listed Not applicable Interventional

Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic)

NCT04957446
View directory record Official record
Conditions
Nasolabial Fold, Facial Wrinkles
Interventions
Sculptra Aesthetic, Placebo
Device · Other
Lead sponsor
Sadick Research Group
Other
Eligibility
30 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Oct 25, 2026, 9:23 PM EDT
Active, not recruiting Not applicable Interventional

Study to Evaluate the Safety and Effectiveness of GP0116

NCT05987163
View directory record Official record
Conditions
Skin Manifestations
Interventions
GP0116, Active Comparator: FDA approved dermal filler device (RHA 3)
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
18
States / cities
Santa Monica, California • Vista, California • Westport, Connecticut + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft

NCT00877279
View directory record Official record
Conditions
Facial Wrinkles
Interventions
CosmoDerm1, Belotero Soft
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Los Angeles, California • San Francisco, California • New Haven, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 15, 2013 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Phase 3 Interventional

DL6049 vs CosmoPlast in the Treatment of Nasolabial Fold Wrinkles

NCT00444210
View directory record Official record
Conditions
Nasolabial Fold Wrinkles
Interventions
DL6049 (injectable poly-L-lactic acid)
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Study of JUVÉDERM VOLIFT® XC Versus Control for Moderate to Severe Nasolabial Folds

NCT01976663
View directory record Official record
Conditions
Moderate to Severe Nasolabial Folds
Interventions
JUVEDERM VOLIFT® XC, Control
Device
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
7
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated May 10, 2019 · Synced Oct 25, 2026, 9:23 PM EDT
Terminated Phase 4 Interventional Results available

Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections

NCT00716443
View directory record Official record
Conditions
Nasolabial Folds
Interventions
tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
Drug
Lead sponsor
Galderma R&D
Industry
Eligibility
30 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
4
States / cities
Aventura, Florida • West Palm Beach, Florida • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

Safety Study That Compares Perlane to Perlane With Lidocaine (Perlane-L) While Correcting Wrinkles in the Area Around Your Nose

NCT00823069
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Perlane and Perlane-L
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
3
States / cities
Coral Gables, Florida • Hunt Valley, Maryland • Mount Cisco, New York
Source: ClinicalTrials.gov public record
Updated Nov 30, 2010 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

Extension Study for 43USSA1705

NCT04225273
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Sculptra Aesthetic, Lidocaine HCL
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
4
States / cities
Scottsdale, Arizona • Bradenton, Florida • Austin, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction

NCT06351293
View directory record Official record
Conditions
Wrinkle
Interventions
Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Santa Rosa Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color

NCT01012388
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Los Angeles, California • Chevy Chase, Maryland • Ypsilanti, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2013 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety Study of Cosmetic Tissue Augmentation in People of Color

NCT01147172
View directory record Official record
Conditions
Wrinkles
Interventions
Elevess
Device
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
9
States / cities
Los Angeles, California • Boca Raton, Florida • Coral Gables, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.

NCT00876265
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Belotero, Zyplast
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2013 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

Effectiveness and Safety of Princess FILLER Lidocaine in Correction of Nasolabial Folds (NLF)

NCT03990883
View directory record Official record
Conditions
Dermatological Non-Disease
Interventions
Princess Filler Lidocaine
Device
Lead sponsor
Croma-Pharma GmbH
Industry
Eligibility
22 Years and older
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
11
States / cities
Birmingham, Alabama • Beverly Hills, California • San Diego, California + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds

NCT00874094
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Platelet rich fibrin matrix
Biological
Lead sponsor
The New York Eye & Ear Infirmary
Other
Eligibility
25 Years to 75 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chappaqua, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2013 · Synced Oct 25, 2026, 9:23 PM EDT
Active, not recruiting Not applicable Interventional

Safety and Effectiveness of ELLANSÉ®-S Dermal Filler in the Treatment of Nasolabial Folds

NCT06984835
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Ellanse S, Calcium Hydroxylapatite-based filler
Device
Lead sponsor
AQTIS Medical B.V.
Other
Eligibility
22 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
7
States / cities
Scottsdale, Arizona • Encino, California • Westport, Connecticut + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 25, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA® 4 NLF Cannula

NCT04754646
View directory record Official record
Conditions
Wrinkle, Nasolabial Fold, Aging
Interventions
Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
4
States / cities
Encinitas, California • West Palm Beach, Florida • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Oct 25, 2026, 9:23 PM EDT