Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.

Clear filters
ClinicalTrials.gov public records Last synced Jul 23, 2026, 5:56 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Nasolabial Fold Wrinkles Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation

NCT04128046
View directory record Official record
Conditions
Skin Rejuvenation, Skin Quality, Wrinkle, Nasolabial Fold
Interventions
PRFM injection, Saline injection
Procedure
Lead sponsor
New York Medical College
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Jul 23, 2026, 5:56 PM EDT
Active, not recruiting Not applicable Interventional

Study to Evaluate the Safety and Effectiveness of GP0116

NCT05987163
View directory record Official record
Conditions
Skin Manifestations
Interventions
GP0116, Active Comparator: FDA approved dermal filler device (RHA 3)
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
18
States / cities
Santa Monica, California • Vista, California • Westport, Connecticut + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 4 Interventional Results available

Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study)

NCT02176356
View directory record Official record
Conditions
Facial Rhytides, Crow's Feet Lines, Glabellar Lines, Nasolabial Fold
Interventions
onabotulinumtoxinA, bimatoprost ophthalmic solution 0.03%, JUVÉDERM® ULTRA XC, JUVÉDERM® ULTRA PLUS XC, JUVÉDERM® VOLUMA® XC
Biological · Drug · Device
Lead sponsor
Allergan
Industry
Eligibility
35 Years to 65 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 3 Interventional

DL6049 Versus Cosmoplast in the Treatment of Nasolabial Fold Wrinkles, Long Term Follow-up

NCT00444353
View directory record Official record
Conditions
Nasolabial Fold Wrinkles
Interventions
DL6049 (injectable poly-L-lactic acid)
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines, and Juvéderm® Ultra XC for the Correction of Nasolabial Folds

NCT02195427
View directory record Official record
Conditions
Nasolabial Folds, Wrinkles
Interventions
TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
5
States / cities
Birmingham, Alabama • Beverly Hills, California • Santa Monica, California + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Safety Study That Compares Perlane to Perlane With Lidocaine (Perlane-L) While Correcting Wrinkles in the Area Around Your Nose

NCT00823069
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Perlane and Perlane-L
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
3
States / cities
Coral Gables, Florida • Hunt Valley, Maryland • Mount Cisco, New York
Source: ClinicalTrials.gov public record
Updated Nov 29, 2010 · Synced Jul 23, 2026, 5:56 PM EDT
Active, not recruiting Not applicable Interventional

Safety and Effectiveness of ELLANSÉ®-S Dermal Filler in the Treatment of Nasolabial Folds

NCT06984835
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Ellanse S, Calcium Hydroxylapatite-based filler
Device
Lead sponsor
AQTIS Medical B.V.
Other
Eligibility
22 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
7
States / cities
Scottsdale, Arizona • Encino, California • Westport, Connecticut + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

TEOSYAL® RHA Ultra Deep and Perlane-L® for the Correction of Nasolabial Folds

NCT02253147
View directory record Official record
Conditions
Nasolabial Folds, Wrinkles
Interventions
TEOSYAL® RHA Ultra Deep
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
4
States / cities
Beverly Hills, California • Bradenton, Florida • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2018 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler

NCT01012661
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler Mixed with Lidocaine, Radiesse® Injectable Dermal Filler without Lidocaine
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Rockville, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction

NCT06351293
View directory record Official record
Conditions
Wrinkle
Interventions
Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Santa Rosa Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds

NCT00414544
View directory record Official record
Conditions
Facial Wrinkles
Interventions
CosmetaLife, Restylane
Device
Lead sponsor
Cosmeta
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
5
States / cities
Tracy, California • Roswell, Georgia • Chestnut Hill, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2011 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.

NCT00876265
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Belotero, Zyplast
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 4 Interventional

A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique.

NCT00293163
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Hylaform, Hylaform Plus (hylan B gel)
Device
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
3
States / cities
Los Angeles, California • Warren, Michigan • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 4, 2015 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 3 Interventional

DL6049 vs CosmoPlast in the Treatment of Nasolabial Fold Wrinkles

NCT00444210
View directory record Official record
Conditions
Nasolabial Fold Wrinkles
Interventions
DL6049 (injectable poly-L-lactic acid)
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Isolagen TherapyTM in the Treatment of Nasolabial Fold Wrinkles

NCT00649428
View directory record Official record
Conditions
Bilateral Nasolabial Fold Wrinkles
Interventions
Autologous Human Fibroblast (azficel-T), Placebo
Biological
Lead sponsor
Castle Creek Biosciences, LLC.
Industry
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
7
States / cities
Birmingham, Alabama • Newport Beach, California • Coral Gables, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2012 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds

NCT00797459
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Restylane and Restylane-L
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2013 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft

NCT00877279
View directory record Official record
Conditions
Facial Wrinkles
Interventions
CosmoDerm1, Belotero Soft
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Los Angeles, California • San Francisco, California • New Haven, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2013 · Synced Jul 23, 2026, 5:56 PM EDT
Not listed Not applicable Interventional

Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic)

NCT04957446
View directory record Official record
Conditions
Nasolabial Fold, Facial Wrinkles
Interventions
Sculptra Aesthetic, Placebo
Device · Other
Lead sponsor
Sadick Research Group
Other
Eligibility
30 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Safety and Effectiveness of Belotero® in Subjects With Fitzpatrick Phototypes IV Through VI

NCT00922623
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Belotero®
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
3
States / cities
Los Angeles, California • Mitchellville, Maryland • Montclair, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 4 Interventional Results available

Sculptra Aesthetic Post-Approval Study

NCT02425943
View directory record Official record
Conditions
Nasolabial Fold Contour Deficiencies, Wrinkles
Interventions
injectable poly-L-lactic acid Sculptra Aesthetic
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
18 Years to 75 Years
Enrollment
867 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
18
States / cities
Birmingham, Alabama • Encino, California • Hermosa Beach, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

PREVELLE Shape (CX002) Dermal Filler Protocol

NCT00764257
View directory record Official record
Conditions
Correction of Nasolabial Folds and Lip Augmentation
Interventions
PREVELLE Shape, Restylane
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Dec 19, 2011 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 3 Interventional Results available

A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)

NCT00444626
View directory record Official record
Conditions
Facial Wrinkles at the Nasolabial Folds
Interventions
Dermal Gel Extra (DGE), Restylane, EMLA Cream
Device · Drug
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • La Jolla, California • Miami Beach, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA® 4 NLF Cannula

NCT04754646
View directory record Official record
Conditions
Wrinkle, Nasolabial Fold, Aging
Interventions
Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
4
States / cities
Encinitas, California • West Palm Beach, Florida • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Jul 23, 2026, 5:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules.

NCT00765583
View directory record Official record
Conditions
Rhytids
Interventions
Restylane
Drug
Lead sponsor
Medicis Aesthetics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Chicago, Illinois • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2011 · Synced Jul 23, 2026, 5:56 PM EDT