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ClinicalTrials.gov public records Last synced Oct 29, 2026, 11:24 AM EDT

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Showing 1–24 of 100 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Natriuretic Peptides Clear all
Active, not recruiting Phase 3 Interventional

An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia

NCT03424018
View directory record Official record
Conditions
Achondroplasia
Interventions
BMN 111
Drug
Lead sponsor
BioMarin Pharmaceutical
Industry
Eligibility
6 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2031
U.S. locations
11
States / cities
Oakland, California • Torrance, California • Wilmington, Delaware + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Natriuretic Peptide Response to Saline Infusion

NCT04223531
View directory record Official record
Conditions
Obesity
Interventions
Normal Saline 0.9% Infusion Solution Bag
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 23, 2023 · Synced Oct 29, 2026, 11:24 AM EDT
Terminated Phase 2 Interventional

REGN5381 in Adult Participants With Heart Failure With Reduced Ejection Fraction

NCT06237309
View directory record Official record
Conditions
Heart Failure
Interventions
REGN5381, Placebo
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
4
States / cities
Phoenix, Arizona • Torrance, California • Miami, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Phase 1Phase 2 Interventional

Safety Study of Cenderitide in Chronic Stable Heart Failure With Moderate Renal Impairment

NCT02603614
View directory record Official record
Conditions
Heart Failure, Renal Insufficiency
Interventions
Cenderitide, Placebo
Drug
Lead sponsor
Capricor Inc.
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Tustin, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of Aliskiren and Valsartan Versus Placebo in Patients Stabilized Following an Acute Coronary Syndrome

NCT00409578
View directory record Official record
Conditions
Post Acute Coronary Syndrome, Myocardial Ischemia
Interventions
Placebo, Aliskiren 300 mg, Valsartan 320 mg, Aliskiren/valsartan 300/320 mg
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years and older
Enrollment
1,101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Investigative Site, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 19, 2011 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Not applicable Interventional

Provider Notification for High B-type Natriuretic Peptide Values

NCT01734135
View directory record Official record
Conditions
Heart Failure
Interventions
Clinical Reminder
Other
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years to 120 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2025 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects

NCT01977859
View directory record Official record
Conditions
Obesity, Cardiovascular Disease, Hypertension, Diabetes
Interventions
Nesiritide, Saline
Drug
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2018 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Phase 3 Interventional

Safety and Efficacy Study of Carvedilol to Treat Children With Congestive Heart Failure

NCT00052026
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
carvedilol, placebo
Drug
Lead sponsor
Shaddy, Robert, M.D.
Individual
Eligibility
1 Day to 17 Years
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2006
U.S. locations
21
States / cities
Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 16 more
Source: ClinicalTrials.gov public record
Updated Dec 25, 2008 · Synced Oct 29, 2026, 11:24 AM EDT
Active, not recruiting Phase 3 Interventional

Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia

NCT06455059
View directory record Official record
Conditions
Hypochondroplasia
Interventions
Vosoritide, Placebo
Drug
Lead sponsor
BioMarin Pharmaceutical
Industry
Eligibility
3 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Wilmington, Delaware • Washington D.C., District of Columbia • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Natriuretic Peptide System in African-Americans.

NCT02730780
View directory record Official record
Conditions
Healthy, Prehypertension
Interventions
Low-Salt Diet, High-Salt Diet
Dietary Supplement
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 9, 2022 · Synced Oct 29, 2026, 11:24 AM EDT
Enrolling by invitation Phase 1Phase 2 Interventional

Enhancing the Natriuretic Peptide System in HFpEF

NCT05279742
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Chronic Kidney Diseases
Interventions
MANP, Sacubitril/Valsartan, Oral Placebo, Injection Placebo
Drug
Lead sponsor
Horng Chen
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 29, 2026, 11:24 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Metabolic Effects of Natriuretic Peptide Hormones

NCT03397966
View directory record Official record
Conditions
Obesity, Cardiovascular Physiological Phenomena, Metabolism
Interventions
recombinant human BNP(1-32), placebo (control, normal saline)
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 40 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Oct 29, 2026, 11:24 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Examination of the Role of Atrial Natriuretic Peptide Polymorphisms in Allergic Rhinitis and Asthma Severity

NCT00584051
View directory record Official record
Conditions
Asthma, Allergic Rhinitis
Interventions
Not listed
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Oct 4, 2018 · Synced Oct 29, 2026, 11:24 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

CARBON: UAB Cardiovascular Research Biobank

NCT05067231
View directory record Official record
Conditions
Natriuretic Peptides, Cardiovascular Diseases, Hypertension, Diabetes, Obesity
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Phase 3 Interventional

Brain Natriuretic Peptide (BNP) to Preserve Renal Function in Hospitalized Patients With Heart Failure

NCT00170183
View directory record Official record
Conditions
Kidney Diseases, Congestive Heart Failure, Cardiomyopathy
Interventions
Nesiritide
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 16, 2009 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.

NCT00405548
View directory record Official record
Conditions
Left Ventricular Diastolic Dysfunction
Interventions
BNP (nesiritide), Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 1, 2015 · Synced Oct 29, 2026, 11:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Beige Fat, Energy, and the Natriuretic Peptide System

NCT04357964
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 1, 2024 · Synced Oct 29, 2026, 11:24 AM EDT
Recruiting No phase listed Observational

Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

NCT06849752
View directory record Official record
Conditions
Heart Failure, Socioeconomic Adversity
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 29, 2026, 11:24 AM EDT
Active, not recruiting Phase 2 Interventional

An Extension Study to Evaluate Safety and Efficacy of BMN 111 in Children With Achondroplasia

NCT03989947
View directory record Official record
Conditions
Achondroplasia
Interventions
Active BMN 111: Subcutaneous injection of recommended dose of BMN 111 based on weight-band dosing once daily.
Drug
Lead sponsor
BioMarin Pharmaceutical
Industry
Eligibility
15 Months and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2038
U.S. locations
9
States / cities
Oakland, California • Torrance, California • Wilmington, Delaware + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 29, 2026, 11:24 AM EDT
Not listed No phase listed Observational

Correlations Between BNP & Dry Weight, and Between Troponin & Mortality, in Hemodialysis Patients

NCT00416013
View directory record Official record
Conditions
Kidney Failure, Chronic, Heart Failure, Congestive
Interventions
Not listed
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 85 Years
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2010 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function

NCT00405639
View directory record Official record
Conditions
Heart Failure, Asymptomatic Systolic Dysfunction
Interventions
Nesiritide, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 17, 2014 · Synced Oct 29, 2026, 11:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Diurnal Rhythm in Natriuretic Peptide Levels

NCT03834168
View directory record Official record
Conditions
Natriuretic Peptides, Obesity, Nocturnal Blood Pressure
Interventions
standardized Study Diet
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 5, 2024 · Synced Oct 29, 2026, 11:24 AM EDT
Completed No phase listed Observational

Study to Determine if Serum BNP Levels Are Elevated in Pregnant Women With Pre-Eclampsia

NCT00533871
View directory record Official record
Conditions
Preeclampsia
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2007 · Synced Oct 29, 2026, 11:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

NT-proBNP Levels and Obesity in Pregnancy

NCT04049136
View directory record Official record
Conditions
Obesity, Pregnancy Complications, Peripartum Cardiomyopathy
Interventions
NT-proBNP
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Oct 29, 2026, 11:24 AM EDT