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ClinicalTrials.gov public records Last synced Oct 1, 2026, 3:28 PM EDT

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Showing 49–72 of 105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Negative-Pressure Wound Therapy Clear all
Completed Not applicable Interventional

Vacuum Assisted Closure as a Treatment for Draining Hematomas

NCT00582179
View directory record Official record
Conditions
Draining Hematoma
Interventions
Standard Pressure Dressing, VAC
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 1, 2013 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional Results available

Procellera and Negative Pressure Therapy for Acute Wounds

NCT01938066
View directory record Official record
Conditions
Wound
Interventions
Procellera, negative pressure therapy
Device
Lead sponsor
Gayle Gordillo
Other
Eligibility
18 Years to 69 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2016 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional Results available

Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)

NCT02470806
View directory record Official record
Conditions
Venous Leg Ulcers, Diabetic Foot Ulcers
Interventions
PICO System, tNPWT System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
15
States / cities
Carlsbad, California • Fresno, California • Martinez, California + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional

Evaluating Blast-X® in Combination With Negative Pressure Wound Therapy

NCT04265170
View directory record Official record
Conditions
Pressure Ulcer
Interventions
BlastX with negative pressure therapy
Device
Lead sponsor
SerenaGroup, Inc.
Network
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Kittanning, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional

Interventional Study Exploring the Occurrence of Surgical Site Infections.

NCT06661473
View directory record Official record
Conditions
Total Knee Arthroplasty, Total Hip Arthroplasty Revision, Total Knee Arthroplasty Revision
Interventions
Avance Solo Negative Pressure Wound Therapy
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
8
States / cities
Washington D.C., District of Columbia • Indianapolis, Indiana • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 1, 2026, 3:28 PM EDT
Terminated Not applicable Interventional Results available

Negative Pressure Wound Therapy With Instillation of Saline Solution Versus Collagenase Ointment in Full-thickness Wounds

NCT03722485
View directory record Official record
Conditions
Wounds and Injuries, Wound Healing, Granulation Tissue
Interventions
Negative Pressure Therapy w/ instillation and dwell (NPWTi-d), Collagenase Ointment
Device · Biological
Lead sponsor
KCI USA, Inc
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
10
States / cities
Phoenix, Arizona • Tucson, Arizona • Washington D.C., District of Columbia + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 1, 2026, 3:28 PM EDT
Terminated Not applicable Interventional Results available

Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA

NCT04712019
View directory record Official record
Conditions
Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases, Musculoskeletal Diseases, Edema Leg, Joint Pain, Arthritis Knee
Interventions
Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
6
States / cities
Annapolis, Maryland • Baltimore, Maryland • Columbia, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 1, 2026, 3:28 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Prospective Observation of Wound Healing With Prevena Incision Management System

NCT01704924
View directory record Official record
Conditions
Scarring
Interventions
Prevena, Standard of Care Dressing
Device · Procedure
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2018 · Synced Oct 1, 2026, 3:28 PM EDT
Withdrawn Not applicable Interventional

A Comparison of Incisional Negative-Pressure Wound Therapy Versus Conventional Dressings Following Abdominal Surgery

NCT02534116
View directory record Official record
Conditions
Abdominal Reconstruction
Interventions
Vacuum-assisted closure (VAC) therapy, Gauze dressing
Procedure
Lead sponsor
Yale University
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.

NCT02127281
View directory record Official record
Conditions
Prosthesis-related Infections, Wound Complications, Joint Diseases, Musculoskeletal Diseases
Interventions
Prevena
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional

Wound Vac Polypropylene Suture Pilot Study

NCT02929238
View directory record Official record
Conditions
Wound Vac, Suture
Interventions
Polypropylene Suture Right Side, Polypropylene Suture Left Side
Other
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 13, 2018 · Synced Oct 1, 2026, 3:28 PM EDT
Terminated Not applicable Interventional

Evaluation of V.A.C. VERAFLO CLEANSE CHOICE™ Dressing Using Normal Saline to Promote Increased Healthy Wound Bed Tissue

NCT04026334
View directory record Official record
Conditions
Wound, Wound Heal, Wounds and Injuries, Granulation Tissue, Negative-pressure Wound Therapy
Interventions
V.A.C. VERAFLO CLEANSE CHOICE™ dressing with Normal Saline
Device
Lead sponsor
3M
Industry
Eligibility
22 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional Results available

Single-Use Negative Pressure Wound Therapy for Free Flap Donor Sites

NCT03340025
View directory record Official record
Conditions
Surgical Wound
Interventions
PICO Single Use Negative Pressure Wound Therapy System, xeroform gauze
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 30, 2021 · Synced Oct 1, 2026, 3:28 PM EDT
Recruiting Phase 4 Interventional

Combined OFM and Vacuum-assisted Therapy for Expedited Regeneration Over Structures

NCT07385313
View directory record Official record
Conditions
Soft Tissue Defects, Soft Tissue Wounds, Traumatic Soft Tissue Defect
Interventions
Myriad™ applied in conjunction with NPWT, NPWT Alone
Device
Lead sponsor
Aroa Biosurgery Limited
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Aurora, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 1, 2026, 3:28 PM EDT
Active, not recruiting Not applicable Interventional

Delayed Primary Closure Using Negative Pressure Wound Therapy

NCT04042259
View directory record Official record
Conditions
Infection Abdominal
Interventions
Abthera, Open adbdomen for post-laparotomy without NPWT device
Device · Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 1, 2026, 3:28 PM EDT
Withdrawn Not applicable Interventional

Incisional Wound Vac in Obese Patients

NCT00789659
View directory record Official record
Conditions
Wound Infection, Postoperative Complication
Interventions
Negative pressure dressing
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Comparison of Two Methods of Securing Skin Grafts Using Negative Pressure Wound Therapy: Vacuum Assisted Closure (VAC) and Gauze Suction (GSUC)

NCT00952120
View directory record Official record
Conditions
Wound Healing
Interventions
GSUC, VAC
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 24, 2015 · Synced Oct 1, 2026, 3:28 PM EDT
Withdrawn Not applicable Interventional

Non-Comparative Study of Open Abdomen That Require the Use of Negative Pressure Wound Therapy (NPWT) for Temporary Abdominal Closure

NCT03431220
View directory record Official record
Conditions
Abdomenal Wound Trauma
Interventions
RENASYS® TOUCH Negative Pressure Wound Therapy (NPWT) Device
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 13, 2018 · Synced Oct 1, 2026, 3:28 PM EDT
Not listed Phase 4 Interventional

Pilonidal Disease Wound Healing Study

NCT01857128
View directory record Official record
Conditions
Pilonidal Disease
Interventions
Drawtex dressing, Negative Pressure Wound Therapy
Device
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 20, 2013 · Synced Oct 1, 2026, 3:28 PM EDT
Not listed Not applicable Interventional

A Prospective, Randomized, Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO) or Standard Care Dressings (AQUACEL Ag SURGICAL Dressing).

NCT03180346
View directory record Official record
Conditions
Surgical Incision
Interventions
PICO, Aquacel
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Phase 3 Interventional Results available

Negative Pressure Wound Therapy in Post-Operative Incision Management

NCT02682316
View directory record Official record
Conditions
Negative-Pressure Wound Therapy
Interventions
dry gauze, The Prevena Incision Management System
Other · Device
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
583 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
10
States / cities
Hartford, Connecticut • Basking Ridge, New Jersey • Middletown, New Jersey + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional Results available

SNaP Wound Care System Versus Traditional NPWT Device for Treatment of Chronic Wounds

NCT00951080
View directory record Official record
Conditions
Ulcers, Wounds
Interventions
Traditional NPWT System, SNaP Wound Care System
Device
Lead sponsor
3M
Industry
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
17
States / cities
Phoenix, Arizona • Tucson, Arizona • Castro Valley, California + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Oct 1, 2026, 3:28 PM EDT
Completed Not applicable Interventional Results available

PICO Breast Reduction Clinical Study Looking at Incision Healing Complications

NCT01640366
View directory record Official record
Conditions
Delayed Healing
Interventions
PICO
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
3
States / cities
Chicago, Illinois • The Bronx, New York • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 28, 2020 · Synced Oct 1, 2026, 3:28 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

The Effect of Nitroglycerin Ointment, Fluorescent Angiography, and Incisional Negative Pressure Wound Therapy on Mastectomy Skin Flap Perfusion-Related Problems

NCT03716050
View directory record Official record
Conditions
Perfusion; Complications
Interventions
Nitroglycerin, Negative Pressure Wound Therapy/ Wound VAC, Fluorescent Angiography with indocyanine-green (not to exceed 5mg/kg), No treatment
Drug · Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2020 · Synced Oct 1, 2026, 3:28 PM EDT