- Conditions
- Perinatal Stroke
- Interventions
- Magnetic Resonance Imaging, Behavioral Assessments, Non invasive Transcranial Magnetic Stimulation
- Device · Behavioral
- Lead sponsor
- University of Wisconsin, Madison
- Other
- Eligibility
- 0 Years to 24 Months
- Enrollment
- 65 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2027
- U.S. locations
- 1
- States / cities
- Madison, Wisconsin
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Showing 1–24
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- Conditions
- Neonatal Encephalopathy, Hypoxic Ischaemic Encephalopathy (HIE)
- Interventions
- Not listed
- Lead sponsor
- Boston Children's Hospital
- Other
- Eligibility
- Not listed
- Enrollment
- 300 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2035
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Mild Hypoxic Ischemic Encephalopathy of Newborn
- Interventions
- Normothermia, Whole body therapeutic hypothermia
- Procedure
- Lead sponsor
- University of Texas Southwestern Medical Center
- Other
- Eligibility
- 36 Weeks and older
- Enrollment
- 460 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2029
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Seizures
- Interventions
- Bumetanide, Normal Saline as Placebo
- Drug
- Lead sponsor
- Soul, Janet , M.D.
- Individual
- Eligibility
- Up to 44 Weeks
- Enrollment
- 43 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2019
- U.S. locations
- 4
- States / cities
- Boston, Massachusetts
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia
- Interventions
- Mobility Device, Spinal Stimulation
- Device
- Lead sponsor
- University of Washington
- Other
- Eligibility
- 4 Years to 70 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2023
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Sedation, Sleep
- Interventions
- Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring
- Device
- Lead sponsor
- Artemis AI Labs
- Industry
- Eligibility
- Not listed
- Enrollment
- 200 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2029
- U.S. locations
- 2
- States / cities
- New York, New York
- Conditions
- Hypoxia-Ischemia, Brain, Periventricular Leukomalacia
- Interventions
- Not listed
- Lead sponsor
- Johns Hopkins University
- Other
- Eligibility
- Not listed
- Enrollment
- 4 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2008
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
- Interventions
- EEG, NIRS
- Device
- Lead sponsor
- Sharp HealthCare
- Other
- Eligibility
- Up to 72 Hours
- Enrollment
- 130 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2021
- U.S. locations
- 1
- States / cities
- San Diego, California
- Conditions
- Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy
- Interventions
- Holding, Saliva collection, No Holding
- Behavioral · Other
- Lead sponsor
- MaineHealth
- Other
- Eligibility
- 24 Hours to 2 Days
- Enrollment
- 34 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2021
- U.S. locations
- 1
- States / cities
- Portland, Maine
- Conditions
- Hypoxic Ischemic Encephalopathy
- Interventions
- Topiramate, Placebo
- Drug
- Lead sponsor
- Kristin R Hoffman
- Other
- Eligibility
- Up to 6 Hours
- Enrollment
- 34 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2022
- U.S. locations
- 1
- States / cities
- Sacramento, California
- Conditions
- Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic, Hypoxic-Ischemic Encephalopathy, Ischemic-Hypoxic Encephalopathy
- Interventions
- Whole-body Cooling
- Procedure
- Lead sponsor
- NICHD Neonatal Research Network
- Network
- Eligibility
- Up to 6 Hours
- Enrollment
- 364 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2016
- U.S. locations
- 19
- States / cities
- Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 15 more
- Conditions
- Hypoxic Ischemic Encephalopathy
- Interventions
- Melatonin, Magnetic Resonance Imaging, Pharmacokinetics, Neurological Outcome Assessment
- Drug · Other · Behavioral
- Lead sponsor
- University of Florida
- Other
- Eligibility
- Up to 6 Hours
- Enrollment
- 70 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2027
- U.S. locations
- 2
- States / cities
- Gainesville, Florida • Orlando, Florida
- Conditions
- Hypoxic-ischemic Encephalopathy
- Interventions
- Dexmedetomidine
- Drug
- Lead sponsor
- Seattle Children's Hospital
- Other
- Eligibility
- 1 Hour to 1 Day
- Enrollment
- 7 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2017
- U.S. locations
- 1
- States / cities
- Seattle, Washington
- Conditions
- Hypoxic-Ischemic Encephalopathy Mild, Neonatal Encephalopathy
- Interventions
- Therapeutic Hypothermia, Normothermia
- Other
- Lead sponsor
- Stanford University
- Other
- Eligibility
- Up to 6 Hours
- Enrollment
- 68 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2025
- U.S. locations
- 5
- States / cities
- Loma Linda, California • Oakland, California • Orange, California + 2 more
- Conditions
- Moderate or Severe Hypoxic-ischemic Encephalopathy in Newborns
- Interventions
- Infusion of autologous cord blood, Placebo
- Biological
- Lead sponsor
- Michael Cotten
- Other
- Eligibility
- 0 Hours to 6 Hours
- Enrollment
- 35 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2019
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages, Epilepsy, Cerebral Palsy, Intellectual Disability
- Interventions
- Not listed
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 2 Years to 8 Years
- Enrollment
- 188 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2025
- U.S. locations
- 9
- States / cities
- San Francisco, California • Stanford, California • Washington D.C., District of Columbia + 5 more
- Conditions
- Hypoxic-Ischemic Encephalopathy
- Interventions
- RLS-0071, Placebo
- Drug
- Lead sponsor
- ReAlta Life Sciences, Inc.
- Industry
- Eligibility
- Up to 10 Hours
- Enrollment
- 70 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2028
- U.S. locations
- 15
- States / cities
- Little Rock, Arkansas • Orange, California • San Diego, California + 11 more
- Conditions
- Hypoxic Ischemic Encephalopathy
- Interventions
- Olympic Cool Cap
- Device
- Lead sponsor
- Vanderbilt University
- Other
- Eligibility
- 30 Minutes to 6 Hours
- Enrollment
- 4 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2013
- U.S. locations
- 1
- States / cities
- Nashville, Tennessee
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hypoglycemia, Neonatal Abstinence Syndrome
- Interventions
- nfant feeding solution
- Device
- Lead sponsor
- Boston Children's Hospital
- Other
- Eligibility
- Up to 6 Months
- Enrollment
- 16 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2021
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
- Interventions
- Sensorimotor Intervention
- Behavioral
- Lead sponsor
- University of Southern California
- Other
- Eligibility
- Up to 6 Months
- Enrollment
- 11 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 2
- States / cities
- Los Angeles, California
- Conditions
- Hypoxic-ischemic Encephalopathy
- Interventions
- erythropoietin
- Drug
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- Up to 24 Hours
- Enrollment
- 24 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2012
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Hypoxic-Ischemic Encephalopathy
- Interventions
- Caffeine Citrate 5 mg/kg, Caffeine Citrate 10 mg/kg
- Drug
- Lead sponsor
- University of North Carolina, Chapel Hill
- Other
- Eligibility
- Up to 24 Hours
- Enrollment
- 17 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2024
- U.S. locations
- 1
- States / cities
- Chapel Hill, North Carolina
- Conditions
- Hypoxic Ischemic Encephalopathy
- Interventions
- Darbepoetin alfa, Placebo
- Drug
- Lead sponsor
- University of Utah
- Other
- Eligibility
- Up to 24 Hours
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 7
- States / cities
- Albuquerque, New Mexico • Nashville, Tennessee • Ogden, Utah + 3 more
- Conditions
- Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
- Interventions
- Prospective Clinical and Neurodevelopmental Data Collection
- Other
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 31 Weeks to 42 Weeks
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts