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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Neurobiological Clear all
Recruiting Not applicable Interventional

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

NCT06238700
View directory record Official record
Conditions
Depression
Interventions
pregnenolone, placebo
Dietary Supplement · Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 23, 2026, 8:59 AM EDT
Enrolling by invitation No phase listed Observational

Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study

NCT07222306
View directory record Official record
Conditions
PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
Interventions
1-(2-[+F]fluoroethyl)-L-tryptophan
Drug
Lead sponsor
Wayne State University
Other
Eligibility
19 Years to 69 Years
Enrollment
100 participants
Timeline
2026 – 2030
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 23, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional

Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)

NCT06648642
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 23, 2026, 8:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neurobiological Responses in Alcoholism and Early Trauma

NCT04128228
View directory record Official record
Conditions
Alcohol Use Disorder, Early Trauma Complications
Interventions
8-week outpatient treatment
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Sep 23, 2026, 8:59 AM EDT
Active, not recruiting Not applicable Interventional

Integrative Medicine in Pain Management in Sickle Cell Disease

NCT05045820
View directory record Official record
Conditions
Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing, Magnetic Resonance Imaging, Circulating Biomarkers, Electroencephalography, Functional Near-infrared Spectroscopy
Interventions
needling acupuncture, laser acupuncture
Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 23, 2026, 8:59 AM EDT
Completed Not applicable Interventional Results available

Coaching Alternative Parenting Strategies (CAPS) Study

NCT02684903
View directory record Official record
Conditions
Child Abuse, Self-control, Parenting
Interventions
Parent Child Interaction Therapy
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
3 Years and older
Enrollment
408 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Sep 23, 2026, 8:59 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Neurobiological Effects of Light on MDD

NCT02940769
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
light glasses, sham glasses (placebo)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Sep 23, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional

Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

NCT07023523
View directory record Official record
Conditions
Fibromyalgia
Interventions
Cognitive Behavioral Therapy, Disease Education
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Sep 23, 2026, 8:59 AM EDT
Not listed No phase listed Observational

Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder

NCT05209217
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Ketamine
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
14 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 26, 2022 · Synced Sep 23, 2026, 8:59 AM EDT
Completed Not applicable Interventional Results available

Nicotine Withdrawal Symptoms and Smoking Relapse

NCT01511614
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Transcranial Direct Current Stimulation, sham, Nicotine patch, Placebo patch, Varenicline Pill, Placebo pill, Motivational Interviewing
Device · Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Sep 23, 2026, 8:59 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-Life Depression

NCT05331599
View directory record Official record
Conditions
Depression in Old Age, Recurrence, Cognitive Dysfunction
Interventions
Not listed
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
60 Years and older
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Sep 23, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Results available

Neurobiological Basis of Response to Guanfacine Extended Release in Children and Adolescents With ADHD

NCT01709695
View directory record Official record
Conditions
ADHD, Attention Deficit Hyperactivity Disorder
Interventions
Guanfacine Hydrochloride XR, Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
8 Years to 15 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2018 · Synced Sep 23, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

NCT06725550
View directory record Official record
Conditions
Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing, Magnetic Resonance Imaging, Circulating Biomarkers, Electroencephalography, Functional Near-infrared Spectroscopy
Interventions
needling acupuncture, laser acupuncture
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
14 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 23, 2026, 8:59 AM EDT
Completed Phase 4 Interventional Results available

Neurobiological Basis of Response to Vyvanse in Adults With ADHD: an fMRI Study of Brain Activation

NCT01924429
View directory record Official record
Conditions
ADHD
Interventions
Lisdexamfetamine
Drug
Lead sponsor
Jeffrey Newcorn
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Sep 23, 2026, 8:59 AM EDT
Completed Not applicable Interventional

Mind-body Therapy (Remotely Delivered) for Knee Osteoarthritis

NCT04678999
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Mind-body exercise and education
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2023 · Synced Sep 23, 2026, 8:59 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm

NCT06219915
View directory record Official record
Conditions
Parkinsonian Signs in Older Persons
Interventions
Carbidopa 25 mg, Carbidopa-Levodopa 25/100 mg, Placebo 1, Placebo 2
Drug
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced Sep 23, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Defining Neurobiological Links Between Substance Use and Mental Illness

NCT05538910
View directory record Official record
Conditions
Major Depressive Disorder, Substance Use Disorder, Normal Physiology
Interventions
Placebo Nicotine Patch, Nicotine Patch
Other · Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years
Enrollment
620 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 23, 2026, 8:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)

NCT01123668
View directory record Official record
Conditions
Smoking, ADHD
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Sep 23, 2026, 8:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Neurobiological Model of Anhedonia

NCT05629520
View directory record Official record
Conditions
Anhedonia, Depression
Interventions
Not listed
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 23, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Stress Dynamics and Familial Risk for Depression in Female Adolescents

NCT06816329
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Computer Task Manipulation
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
13 Years to 15 Years · Female only
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 23, 2026, 8:59 AM EDT
Terminated Not applicable Interventional

Using the Neuroscience of Fear Extinction for Anxiety Reduction

NCT03465137
View directory record Official record
Conditions
Social Anxiety
Interventions
Coordinated Anxiety Learning and Management (CALM)
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Sep 23, 2026, 8:59 AM EDT
Not listed Phase 3 Interventional

Repetitive Behavior Disorders in People With Severe Mental Retardation

NCT00491478
View directory record Official record
Conditions
Mental Retardation, Stereotyped Behavior, Self-Injurious Behavior, Compulsive Behavior
Interventions
sertraline
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1992
U.S. locations
2
States / cities
Gainesville, Florida • Morganton, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2007 · Synced Sep 23, 2026, 8:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neuroimaging of Opioid Phase (OPAL)

NCT05905419
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
Opioid Phase
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 23, 2026, 8:59 AM EDT
Active, not recruiting No phase listed Observational

Neurobiological Predictors of Huntington's Disease (PREDICT-HD)

NCT00051324
View directory record Official record
Conditions
Huntington Disease
Interventions
Not listed
Lead sponsor
Jordan Schultz
Other
Eligibility
18 Years and older
Enrollment
1,700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 23, 2026, 8:59 AM EDT