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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Neurocognitive Dysfunction Clear all
Recruiting Not applicable Interventional

Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

NCT04558164
View directory record Official record
Conditions
Cognitive Dysfunction, Memory Disorders in Old Age
Interventions
Active Theta Burst Stimulation, Sham Theta Burst Stimulation
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
55 Years to 100 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Deep Brain Stimulation with LIFUP for Mild Cognitive Impairment and Mild Alzheimer's Disease

NCT03347084
View directory record Official record
Conditions
Brain Imaging, Mild Cognitive Impairment, Alzheimer Disease, Deep Brain Stimulation
Interventions
Excitation, Inhibition
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
55 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2024 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional

A Community Health Worker Program to Support Rural Older Adults

NCT03843333
View directory record Official record
Conditions
Frail Elderly, Cognitive Impairment, Mobility Limitation, Depressive Symptoms
Interventions
Tai Ji Quan: Moving for Better Balance, Behavioral Activation, Resource Navigation, Enhanced Usual Care
Behavioral · Other
Lead sponsor
University of Vermont
Other
Eligibility
65 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Augusta, Maine • Lyme, New Hampshire • Montpelier, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Jul 23, 2026, 5:07 PM EDT
Recruiting Phase 2 Interventional

Cognitive Remediation Intervention to Prepare for Transition of Care

NCT05336201
View directory record Official record
Conditions
Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy, Health-Related Behavior, Coping Skills
Interventions
CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cognitive Impairment in Kidney Disease

NCT00905619
View directory record Official record
Conditions
Kidney Insufficiency, Chronic
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2017
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 17, 2017 · Synced Jul 23, 2026, 5:07 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

NCT07424365
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
Interventions
transcutaneous auricular vagus nerve stimulation, sham stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Active, not recruiting Phase 2 Interventional

A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

NCT06223360
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Low Dose Benfotiamine, High Dose Benfotiamine, Placebo
Drug
Lead sponsor
Alzheimer's Disease Cooperative Study (ADCS)
Other
Eligibility
50 Years to 89 Years
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
47
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Sun City, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Dementia Signal Development Study of Nautilus NeuroWave TM for the Detection of Dementia

NCT02333942
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Frontotemporal Lobar Degeneration, Memory Disorders
Interventions
Nautilus NeuroWaveTM System
Device
Lead sponsor
Jan Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2019 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Energy Metabolism and Cognitive Aging

NCT00777010
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Ketogenic diet, Healthy high carbohydrate diet
Other
Lead sponsor
University of Cincinnati
Other
Eligibility
50 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD)

NCT03824197
View directory record Official record
Conditions
Alzheimer Disease, Cerebral Amyloid Angiopathy
Interventions
EVOO, OO
Other
Lead sponsor
Auburn University
Other
Eligibility
55 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Jul 23, 2026, 5:07 PM EDT
Completed No phase listed Observational

Chemotherapy-Induced Cognitive Impairment

NCT01578083
View directory record Official record
Conditions
Cognitive Symptoms
Interventions
Not listed
Lead sponsor
Jay F. Piccirillo, MD
Other
Eligibility
35 Years to 70 Years · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 25, 2013 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Phase 2 Interventional

A Study to Evaluate RL-007 in the Treatment of Cognitive Impairment Associated With Schizophrenia (CIAS)

NCT05686239
View directory record Official record
Conditions
Cognitive Impairment Associated With Schizophrenia (CIAS), Cognitive Impairment, Schizophrenia
Interventions
RL-007 (Inidascamine), Placebo
Drug
Lead sponsor
Recognify Life Sciences
Industry
Eligibility
18 Years to 55 Years
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
20
States / cities
Culver City, California • Garden Grove, California • Lafayette, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Jul 23, 2026, 5:07 PM EDT
Terminated Not applicable Interventional

Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery

NCT00123539
View directory record Official record
Conditions
Coronary Disease, Cardiovascular Diseases, Heart Diseases, Neurologic Manifestations
Interventions
Estrogen Replacement Therapy, Surgery
Drug · Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
55 Years and older · Female only
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 28, 2016 · Synced Jul 23, 2026, 5:07 PM EDT
Active, not recruiting Not applicable Interventional

nCCR for Chemotherapy Related Cognitive Impairment Randomized Study

NCT05283629
View directory record Official record
Conditions
Chemo-brain, Chemotherapy-Related Cognitive Impairment
Interventions
Neuroplasticity-based Computerized Cognitive Remediation, Active Control Condition
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
35 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Active, not recruiting Phase 2 Interventional

Rapamycin - Effects on Alzheimer's and Cognitive Health

NCT04629495
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Rapamycin, Placebo
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
55 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Phase 2 Interventional

Efficacy and Safety Study for Cognitive Deficits in Adult Subjects With Schizophrenia

NCT01077700
View directory record Official record
Conditions
Cognitive Deficits in Schizophrenia
Interventions
ABT-288 Low Dose, Placebo, ABT-288 High Dose
Drug
Lead sponsor
AbbVie (prior sponsor, Abbott)
Industry
Eligibility
20 Years to 55 Years
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
24
States / cities
Anaheim, California • Garden Grove, California • National City, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jul 23, 2026, 5:07 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Influence of Cognition on Activity and Participation in People With Stroke

NCT05919251
View directory record Official record
Conditions
Stroke, Cognitive Change, Neurological Injury, Cognitive Impairment, Activity, Motor
Interventions
Ageless Grace
Behavioral
Lead sponsor
Saint Joseph's University, Philadelphia
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 25, 2023 · Synced Jul 23, 2026, 5:07 PM EDT
Active, not recruiting Not applicable Interventional

Psychosis TMS Study

NCT05857137
View directory record Official record
Conditions
Psychosis
Interventions
Active TMS, Placebo TMS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional Results available

PRIMA Intervention for Adults With Mild Cognitive Impairment and Their Caregivers

NCT04515875
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Daily Engagement Meaningful Activity (DEMA), Information Support (IS)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 100 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Jul 23, 2026, 5:07 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Determine the Effect on Cognitive Impairment Measures by Providing Hearing-Assistance to Skilled Nursing Facility Residents

NCT03338751
View directory record Official record
Conditions
Hearing Impairment
Interventions
cognitive testing with HAD (PockeTalker) First, Cognitive testing without HAD First
Diagnostic Test
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 8, 2017 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Cognitive and Aerobic Resilience for the Brain

NCT02390453
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Combined Cognitive and Physical, Cognitive, Physical, Active Control
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Guided Meditation as an Adjunct to Enhance Postoperative Recovery

NCT03198039
View directory record Official record
Conditions
Feasibility of a Meditation Program Perioperatively
Interventions
Meditation
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional

Computerized Exercise Training for Cognitive Remediation in Adults With Multiple Sclerosis Treated With Gilenya

NCT02141022
View directory record Official record
Conditions
Multiple Sclerosis, Cognitive Deficits, Gilenya Modifying Therapy for MS
Interventions
plasticity-based computerized cognitive remediation program, Gileyna
Other · Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 9, 2016 · Synced Jul 23, 2026, 5:07 PM EDT
Completed Not applicable Interventional Results available

Feasibility of the Mindfulness-Based Stress Reduction Intervention for Black Women Living With HIV Supplement

NCT04984681
View directory record Official record
Conditions
HIV Infections, Mild Cognitive Impairment
Interventions
Mindfulness, Usual Care
Behavioral · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Jul 23, 2026, 5:07 PM EDT