Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 24, 2026, 8:09 AM EDT

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Showing 817–840 of 1,870 matching trials from the live ClinicalTrials.gov search.
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Brain Health Champion Study

NCT03772977
Conditions
Mild Cognitive Impairment, Dementia, Mild, Subjective Cognitive Decline, At Risk for Cognitive Decline
Interventions
Brain Health Champion
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
60 Years to 79 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Cognitive Decline, Blood Pressure, Hypertension
Interventions
Clinical Support Decision Tool
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
70 Years and older
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Completed Not applicable Interventional Accepts healthy volunteers Results available

Traveling-wave Transcranial Electric Stimulation

NCT05399381
Conditions
Working Memory
Interventions
Transcranial alternating current stimulation (tACS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 45 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Intermittent Fasting on Brain Health

NCT06019195
Conditions
Intermittent Fasting, Aging
Interventions
Time restricted eating
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
55 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Conditions
Delirium, Cognitive Impairment, Post-traumatic Stress Disorder, Depression, Anxiety
Interventions
Haloperidol, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Interventions
Dextrose Water, Caffeine citrate
Drug
Lead sponsor
University of Michigan
Other
Eligibility
70 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Not listed Not applicable Interventional Accepts healthy volunteers

Genes, Exercise, Neurocognitive and Neurodegeneration: Community-Based Approach

NCT02614365
Conditions
Mild Cognitive Impairment
Interventions
Aerobic exercise, Stretch exercise
Behavioral
Lead sponsor
Howard University
Other
Eligibility
55 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2022
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study)

NCT04493320
Conditions
Depression, Cognitive Impairment, Gait Impairment
Interventions
Carbidopa/levodopa, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years and older
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Not listed
Lead sponsor
NeuroVision Imaging
Industry
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Sacramento, California
Conditions
Delirium, Cognitive Impairment, Alzheimer; Early Onset, Trauma, Polytrauma, Traumatic Brain Injury, ICU, Critical Illness
Interventions
Non-interventional observational prospective cohort study
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Conditions
Alzheimer Disease, Primary Progressive Aphasia, Mild Cognitive Impairment
Interventions
repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Charlestown, Massachusetts
Conditions
Substance Abuse, Substance Dependence, Cognitive Impairment
Interventions
Cognitive Training + Work Therapy, Work Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
West Haven, Connecticut
Conditions
Subjective Cognitive Decline
Interventions
Neurotrack Virtual Cognitive Health Program
Behavioral
Lead sponsor
Evidation Health
Industry
Eligibility
60 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Mateo, California
Conditions
Emotion, Impaired Cognition
Interventions
Music, Imagery, Movement, Social Control
Behavioral
Lead sponsor
George Mason University
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Manassas, Virginia
Recruiting Not applicable Interventional Accepts healthy volunteers

Wayfinding Intervention and Long-Term Memory

NCT05625425
Conditions
Long-Term Memory Decline, Mild Cognitive Impairment
Interventions
LabyrinthVR software, Placebo Games software, Labyrinth Tablet software, Labyrinth VR wireless
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Terminated Not applicable Interventional

Dental Carotid Cognitive Study

NCT03755362
Conditions
Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
Interventions
Standard Treatment, Intensive Treatment
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years to 100 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Major Depressive Disorder
Interventions
Lisdexamfetamine Dimesylate (Vyvanse), Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Belmont, Massachusetts
Completed Not applicable Interventional Results available

Noninvasive Brain Stimulation for Mild Cognitive Impairment

NCT03331796
Conditions
Mild Cognitive Impairment, Mild Neurocognitive Disorder, Cognitive Decline, Mental Deterioration, Cognitive Dysfunction, Memory Decline, Memory Loss, Memory Impairment
Interventions
Active rTMS (Bilateral DLPFC), Active rTMS (Bilateral LPC), Placebo rTMS (Inactive)
Device
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
55 Years to 90 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Conditions
AMCI - Amnestic Mild Cognitive Impairment, Sleep Disturbance
Interventions
Trazodone, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Enrolling by invitation Not applicable Interventional

Mild Cognitive Impairment and Neuromodulation

NCT07691918
Conditions
Mild Cognitive Impairment (MCI)
Interventions
Low intensity focused ultrasound, Sham (No Treatment)
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
55 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Conditions
TBI (Traumatic Brain Injury), Cognitive Symptoms
Interventions
A Trauma-informed, Paraprofessional Delivered Virtual Cognitive Rehabilitation Program
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Phase 2 Interventional Results available

Metformin in Amnestic Mild Cognitive Impairment

NCT00620191
Conditions
Mild Cognitive Impairment
Interventions
Metformin, Placebo
Drug
Lead sponsor
Columbia University
Other
Eligibility
55 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
New York, New York
Conditions
Cognitive Decline, Cognitive Change, Inflammation, Emotions
Interventions
Yogurt
Other
Lead sponsor
University of Idaho
Other
Eligibility
50 Years and older
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
4
States / cities
Boise, Idaho • Coeur d'Alene, Idaho • Pocatello, Idaho + 1 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

MI-CBT Adherence Program for Lifestyle Interventions in Older Adults

NCT04817176
Conditions
Mild Cognitive Impairment, Adherence, Patient, Ketosis
Interventions
Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program, Ketogenic Nutrition Program
Behavioral · Other
Lead sponsor
Florida State University
Other
Eligibility
60 Years to 85 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tallahassee, Florida