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ClinicalTrials.gov public records Last synced Jul 23, 2026, 2:57 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Neuronal Plasticity Clear all
Recruiting Phase 2 Interventional

Ketamine for Veterans With Parkinson's Disease

NCT06231563
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Ketamine, Remimazolam
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
40 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Phase 1Phase 2 Interventional Results available

D-serine Augmentation of Neuroplasticity

NCT03711500
View directory record Official record
Conditions
Schizophrenia, Schizo Affective Disorder
Interventions
D-serine, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
New York, New York • Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Jun 13, 2022 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

NCT06264336
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
treadmill training
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional

Immersive Virtual Reality for Chronic Neuropathic Pain After Spinal Cord Injury: A Feasibility Trial

NCT04700033
View directory record Official record
Conditions
Neuralgia, Spinal Cord Injuries, Chronic Pain
Interventions
Somatic IVR (sIVR), Distractive IVR (dIVR), Control IVR (cIVR)
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 22, 2022 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Overcoming Learned Non-Use in Chronic Aphasia

NCT02012374
View directory record Official record
Conditions
Stroke-induced Aphasia
Interventions
Intensive Language Action Therapy
Behavioral
Lead sponsor
University of Massachusetts, Amherst
Other
Eligibility
21 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Amherst, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 19, 2022 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional Results available

Heart-Brain Retraining for Stroke Rehabilitation

NCT02076776
View directory record Official record
Conditions
Stroke
Interventions
Repetitive Task Practice (RTP), Voluntary cycling + RTP, Assisted cycling + RTP
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Maximizing the Impact of Neuroplasticity Using Transcranial Electrical Stimulation Study 1

NCT03896425
View directory record Official record
Conditions
Transcranial Direct Current Stimulation, Healthy
Interventions
Transcranial direct current stimulation (tDCS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Jul 23, 2026, 2:57 PM EDT
Terminated Not applicable Interventional Results available

Brain Stimulation and Rehabilitation for Adults With Chronic, Severe Arm Motor Impairment After Stroke

NCT03538795
View directory record Official record
Conditions
Stroke, Hemiplegia, Hemiparesis
Interventions
iTBS&eCIMT
Combination Product
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 20, 2020 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for Recovery of Ankle Dorsiflexion in Chronic Stroke Survivors

NCT01029912
View directory record Official record
Conditions
Stroke, Hemiparesis, Lower Extremity Paresis
Interventions
Electrical stimulator
Device
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 6, 2017 · Synced Jul 23, 2026, 2:57 PM EDT
Terminated Phase 4 Interventional

Functional Vision in TBI

NCT01214070
View directory record Official record
Conditions
Brain Injuries, Visually Impaired Persons
Interventions
Vision Restoration Therapy, NVT Eye Scanning Therapy, Eccentric Viewing Training, Sham
Other · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 79 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2017 · Synced Jul 23, 2026, 2:57 PM EDT
Completed No phase listed Observational

TMS as a Biological Marker of Neuroplasticity

NCT02867670
View directory record Official record
Conditions
Stroke, Aphasia
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Jul 23, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional

Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair

NCT03610763
View directory record Official record
Conditions
Hand Transplantation, Peripheral Nerve Injuries, Neurologic Rehabilitation
Interventions
Transcranial Direct Current Stimulation, Modified Constraint Induced Movement Therapy
Device · Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
3
States / cities
Louisville, Kentucky • Columbia, Missouri • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Jul 23, 2026, 2:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Strategies for Recovery of Dexterity Post Stroke

NCT01977027
View directory record Official record
Conditions
Stroke With Hemiparesis
Interventions
Alternate Hand Training or Affected Hand Training
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2020 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional

Plantarflexor PAS - Stroke

NCT04515407
View directory record Official record
Conditions
Stroke, Hemiparesis, Gait Dysfunction
Interventions
PAS at Rest, PAS - Active, PAS - Walking
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Martinez, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Jul 23, 2026, 2:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Cognition and Neuroplasticity Sedentary Adults After 8 Weeks of Aerobic Exercise

NCT03804528
View directory record Official record
Conditions
Sedentary Behavior
Interventions
Aerobic Exercise
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
55 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 23, 2026, 2:57 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

TMS Measures of Plasticity and Excitatory/Inhibitory Ratio as Biomarkers: R-baclofen Effects in Normal Volunteers

NCT01172509
View directory record Official record
Conditions
Autism
Interventions
R-baclofen
Drug
Lead sponsor
Gonzalez-Heydrich, Joseph, M.D.
Individual
Eligibility
18 Years to 30 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 20, 2015 · Synced Jul 23, 2026, 2:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Stability of Motor Output in Aging Adults

NCT00970736
View directory record Official record
Conditions
Swallowing
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
60 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Jul 23, 2026, 2:57 PM EDT
Terminated Not applicable Interventional

Improving Hand Recovery With Neuromodulation in Tetraplegia

NCT03954496
View directory record Official record
Conditions
Spinal Cord Injuries, Tetraplegia, Unspecified, Incomplete, Chronic
Interventions
transcranial direct current stimulation, Intensive upper extremity motor training
Device · Behavioral
Lead sponsor
Sara Shahid Salles
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Jul 23, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional

Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

NCT05655325
View directory record Official record
Conditions
Mild Cognitive Impairment, Chronic Kidney Diseases
Interventions
Home-based walking exercise, Attention control
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
55 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional

A Health Game Intervention for Cancer and Post-ICU Patients Suffering From Acute Cognitive Impairment

NCT07596940
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
VR cognitive training platform
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jul 23, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multimodal Investigation of Neural Plasticity

NCT06453980
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
sham tDCS, active tDCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jul 23, 2026, 2:57 PM EDT
Active, not recruiting Phase 1 Interventional

Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder

NCT03554174
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Low Dose Psilocybin, Placebo, Medium Dose Psilocybin
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Jul 23, 2026, 2:57 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Neural Substrates Underlying Adaptations in Manual Dexterity of Older Adults

NCT07011160
View directory record Official record
Conditions
Aging Hands
Interventions
Transcutaneous electrical nerve stimulation (TENS), Familiarization
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
54 Years to 89 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 7, 2025 · Synced Jul 23, 2026, 2:57 PM EDT
Completed Not applicable Interventional Results available

Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury

NCT03854214
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Functional Electric Stimulation cycling, Passive cycling
Device
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 9, 2025 · Synced Jul 23, 2026, 2:57 PM EDT