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Conditions: HELLP Syndrome (HELLP), Third Trimester, Complement Abnormality, Morbidity;Newborn, Maternal Injury, Preeclampsia Severe
Interventions: Eculizumab; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Hypothermia, Neonatal Outcome, Cesarean Section
Interventions: Change in ambient operating room temperature; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: Female only
Enrollment: 5,221 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Hyperglycemia, Leukemia
Interventions: insulin glargine recombinant, therapeutic insulin; Biological · Drug
Lead sponsor: University of Medicine and Dentistry of New Jersey; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Extreme Prematurity, Intraventricular Hemorrhage, Morbidity;Newborn
Interventions: Indomethacin, Placebo; Drug
Lead sponsor: University of British Columbia; Other
Eligibility: 0 Hours to 12 Hours
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 5
States / cities: Roseville, California • Sacramento, California • Pittsburgh, Pennsylvania + 1 more

Conditions: Infant, Newborn, Respiratory Distress Syndrome, Respiratory Insufficiency
Interventions: Early surfactant, Standard practice; Drug
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Up to 12 Hours
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2002
U.S. locations: 13
States / cities: Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 10 more

Conditions: Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis, Cord Blood, Neonatal Brain Injury, Maternal Morbidity, Mechanical Ventilation, CPAP, Surfactant, Perinatal Death, Amnioinfusion, NICU Admission
Interventions: Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider; Device · Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Failure to Thrive, Newborn Morbidity
Interventions: Home weight monitoring; Other
Lead sponsor: The Cleveland Clinic; Other
Eligibility: Not listed
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion, Neonatal Brain Injury
Interventions: Intrauterine Pressure Catheter, Standard obstetric care at discretion of delivery provider; Device · Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Neurofibromatosis 1, Plexiform Neurofibroma
Interventions: Selumetinib; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 1 Year to 8 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2032
U.S. locations: 15
States / cities: Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 11 more

Conditions: Bronchopulmonary Dysplasia
Interventions: Massimo Root Monitoring System, ISA-Infrared Sidestream Gas Analyzer; Device
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 3 Days to 1 Year
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Fetal Growth Abnormality, Amniotic Fluid; Disorder
Interventions: Point-of-care ultrasound (POC-US), Routine antenatal care, Formal ultrasound; Diagnostic Test
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 113 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Preterm Delivery, Obstetrical Complications
Interventions: 162mg Aspirin, 81mg Aspirin; Drug
Lead sponsor: The George Washington University Biostatistics Center; Other
Eligibility: 14 Years and older · Female only
Enrollment: 1,800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 14
States / cities: Birmingham, Alabama • San Francisco, California • Chicago, Illinois + 10 more

Conditions: Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome
Interventions: Standing, Supine; Behavioral
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 13 Years to 60 Years
Enrollment: 139 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Lactic Acidemia
Interventions: Amnioinfusion at room temperature (intervention arm); Procedure
Lead sponsor: Women and Infants Hospital of Rhode Island; Other
Eligibility: 18 Years and older · Female only
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Sleep Apnea, Obesity
Interventions: Not listed
Lead sponsor: MetroHealth Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 182 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Premature Birth of Newborn, Family, Immature Newborn, Newborn Morbidity, Infant Newborn Disease
Interventions: Parent Navigator, Care Notebook; Behavioral
Lead sponsor: Children's National Research Institute; Other
Eligibility: Not listed
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Hypertension in Pregnancy, Obstetrical Complications
Interventions: Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg; Drug · Other
Lead sponsor: The George Washington University Biostatistics Center; Other
Eligibility: 14 Years to 56 Years · Female only
Enrollment: 4,120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 14
States / cities: Birmingham, Alabama • San Francisco, California • Chicago, Illinois + 10 more

Conditions: Hemangioma
Interventions: MRI, MRI of head and neck, Dermatological Examination, Cardiac examination, Abdominal ultrasound; Device · Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: Up to 18 Years
Enrollment: 433 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Sickle Cell Disease, Stroke, Neurologic Manifestations, Neurological Morbidity, Sickle Cell Anemia in Children, Sickle Cell Anemia
Interventions: This study does not entail offering any intervention; all data collected will be based on standard of care.; Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 5 Years to 26 Years
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Prematurity, BPD - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
Interventions: Volume Targeted Ventilation (VTV) using the Philips Respironics NM3 monitor, Tidal Volume Measurement using the Philips Respironics NM3 monitor; Device
Lead sponsor: Baystate Medical Center; Other
Eligibility: 5 Minutes to 60 Minutes
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Springfield, Massachusetts

Conditions: Prematurity, Symptomatic Respiratory Disease, Bronchopulmonary Dysplasia
Interventions: Not listed
Lead sponsor: University of Rochester; Other
Eligibility: Up to 7 Days
Enrollment: 277 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 2
States / cities: Buffalo, New York • Rochester, New York

Conditions: Maternal Morbidity, Antenatal Health, Neonatal Morbidity, Retention in Care, Prenatal Care
Interventions: Patient Navigation Program; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 16 Years to 50 Years · Female only
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Neonatal Respiratory Failure, Tracheal Intubation Morbidity
Interventions: Apneic Oxygenation, Standard of Care; Procedure
Lead sponsor: University of Pennsylvania; Other
Eligibility: 0 Days to 365 Days
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Periventricular Leukomalacia, Chronic Lung Disease, Ileal Perforation
Interventions: Antibiotic, Gastric fluid, Breast milk, Stool samples, Antibiotics; Drug · Other
Lead sponsor: University of Florida; Other
Eligibility: 23 Weeks to 33 Weeks
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Gainesville, Florida

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The Use of Eculizumab in HELLP Syndrome

Hypothermia and the Effect of Ambient Temperature 2

Intensive Glycemic Control on Infectious Morbidity In Patients With Acute Leukemia

Single-dose Prophylactic INdomethacin in Extremely Preterm Infants

Early Surfactant to Reduce Use of Mechanical Breathing in Low Birth Weight Infants

Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure

Impact of Home Weight Tele-monitoring on the Number of Office Visits in the First Six Weeks of Life in Infants.

Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury Biomarkers

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

Hypercapnia and Its Association With Long-term Respiratory Morbidities in Premature Infants With Chronic Lung Disease

Serial Third Trimester Abdominal Circumference and Amniotic Fluid Measurements Versus Routine Care

Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

Standing Cognition and Co-morbidities of POTS Evaluation

Amnioinfusion for Intrauterine Neuroprotection

Sleep Apnea in Pregnancy Screening Study

GPS (Giving Parents Support): Parent Navigation After NICU Discharge

Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial

Hemangioma Associated With High Rates of Morbidity

The Afolabi Stroke Registry for Children and Young Adults With SCD in Northern Nigeria

Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room

Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies

Partnering With Antenatal Navigators to Transform Health in Pregnancy

Providing Oxygen During Intubation in the NICU Trial

Antibiotic "Dysbiosis" in Preterm Infants