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ClinicalTrials.gov public records Last synced Oct 24, 2026, 3:03 AM EDT

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Showing 385–408 of 497 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Nicotine Addiction Clear all
Terminated Not applicable Interventional

Contingency Management for Smoking Cessation Among Veterans With Psychotic Disorders

NCT00508560
View directory record Official record
Conditions
Nicotine Dependence, Psychotic Disorders
Interventions
Contingency Management, Reward
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 26, 2015 · Synced Oct 24, 2026, 3:03 AM EDT
Recruiting Not applicable Interventional

Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

NCT06837220
View directory record Official record
Conditions
Nicotine Use Disorder, Smoking Cessation, Smoking Cessation Intervention
Interventions
Enhanced Courage to Quit
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 26 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Phase 2 Interventional

Very Low-Nicotine Cigarettes in Smokers With SUD

NCT01989507
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking Cessation Behavioral Treatment Study

NCT03948893
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Mindfulness-Oriented Recovery Enhancement (MORE), Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
2
States / cities
Columbia, Missouri • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Identify Biomarkers of Tobacco Exposure and Nicotine Uptake From JUUL 5% in Adult Smokers

NCT03463837
View directory record Official record
Conditions
Nicotine Dependence, Other Tobacco Product, Tobacco Use, Smoking, Tobacco
Interventions
Treatment with JUUL 5%, Virginia Tobacco, Treatment with JUUL 5%, Cool Mint, ENDS, Treatment with JUUL 5%, Mango, ENDS, JUUL 5%, Creme Bruele, ENDS, Combustible cigarette, Smoking Cessation
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 21, 2021 · Synced Oct 24, 2026, 3:03 AM EDT
Active, not recruiting Phase 3 Interventional

Optimizing Tobacco Use Treatment for PLWHA

NCT04176172
View directory record Official record
Conditions
HIV/AIDS, Nicotine Dependence
Interventions
Varenicline, Nicotine patch, Standard treatment, Standard treatment + Managed Problem Solving (MAPS) adherence intervention
Drug · Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Phase 3 Interventional Results available

Pharmacogenetics of Nicotine Addiction Treatment

NCT01314001
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Varenicline, Placebo, Transdermal Nicotine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
1,246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Buffalo, New York • Philadelphia, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Results available

Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers

NCT00934024
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varenicline
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Oct 24, 2026, 3:03 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

NCT07460622
View directory record Official record
Conditions
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
Interventions
Virtual Reality E-Cigarette Prevention Program
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 24, 2026, 3:03 AM EDT
Recruiting Early Phase 1 Interventional

Addictive Threshold of Nicotine

NCT06096714
View directory record Official record
Conditions
Smoking Addiction
Interventions
Nicotine, Saline
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 59 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 24, 2026, 3:03 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Addiction Potential of Very Low Nicotine Filtered Little Cigars

NCT06630728
View directory record Official record
Conditions
Smoking (Tobacco) Addiction
Interventions
Reduced Nicotine Content Cigars, Normal nicotine content cigar, Usual brand cigar
Drug
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Phase 4 Interventional Results available

The END Perioperative Smoking Pilot Study

NCT02482233
View directory record Official record
Conditions
Smoking, Nicotine Addiction, Surgery
Interventions
ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Phase 2 Interventional Results available

Combination Nicotine Patch / Lorcaserin for Smoking Cessation

NCT02906644
View directory record Official record
Conditions
Nicotine Dependence
Interventions
lorcaserin, nicotine patch, placebo lorcaserin
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 7, 2019 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Nicotine Pharmacokinetics From Research Electronic Nicotine Delivery System S-TA-U001 in Smokers and E-Cigarette Users

NCT02792426
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Research ENDS S-TA-U001, Nicorette Inhalator
Drug
Lead sponsor
NJOY, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated May 17, 2018 · Synced Oct 24, 2026, 3:03 AM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

NCT00419731
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion, Bupropion + Naltrexone
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 3, 2009 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Results available

Cognitive Training for Nicotine Dependence

NCT01252966
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Addiction
Interventions
Cognitive Training, Control training
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2017 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Results available

Brain Stimulation For Cancer Smokers

NCT03419741
View directory record Official record
Conditions
Cancer of Head and Neck, Breast Cancer, Prostate Cancer, Nicotine Dependence
Interventions
Transcranial Magnetic Stimulation Clinical Research System
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 13, 2022 · Synced Oct 24, 2026, 3:03 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment

NCT03213418
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use, Tobacco Dependence, Tobacco Use Disorder, Tobacco Smoking, Cigarette Smoking, Nicotine Dependence, Nicotine Use Disorder, Smoking, Smoking, Cigarette
Interventions
Contingency management
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 5, 2023 · Synced Oct 24, 2026, 3:03 AM EDT
Completed No phase listed Observational

HIV Infection and Tobacco Use Among Injection Drug Users in Baltimore, Maryland: A Pilot Study of Biomarkers

NCT00491335
View directory record Official record
Conditions
HIV Infections, AIDS, Lung Cancer, Tobacco Addiction, Drug Addiction
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
17 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Testing Financial Incentive Interventions in Dyadic-Smoker Couples

NCT04832360
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Financial Incentives
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarettes and Blood Vessel Function

NCT02740595
View directory record Official record
Conditions
Nicotine Dependence
Interventions
one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Oct 24, 2026, 3:03 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

NCT01036581
View directory record Official record
Conditions
Drug Abuse, Nicotine Dependence
Interventions
MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Not applicable Interventional Results available

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

NCT03612960
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Very low nicotine content cigarettes, Normal nicotine content cigarettes
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Oct 24, 2026, 3:03 AM EDT
Completed Phase 2 Interventional Results available

N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers

NCT00967005
View directory record Official record
Conditions
Gambling, Tobacco Use Disorder
Interventions
N Acetyl Cysteine, Sugar Pill
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
2
States / cities
New Haven, Connecticut • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Oct 24, 2026, 3:03 AM EDT