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ClinicalTrials.gov public records Last synced Oct 24, 2026, 6:06 AM EDT

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Showing 433–456 of 497 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Nicotine Addiction Clear all
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)

NCT01842334
View directory record Official record
Conditions
Nicotine Dependence, Smoking Cessation
Interventions
Cognitive Behavioral Therapy, Nicotine Replacement Therapy
Behavioral · Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Oct 24, 2026, 6:06 AM EDT
Terminated Phase 2 Interventional Results available

Effects of ABT-089 on Smoking Abstinence Symptoms and Reward

NCT01756053
View directory record Official record
Conditions
Nicotine Addiction
Interventions
ABT-089, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 29, 2014 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Varenicline on Cigarette Self Administration

NCT00731055
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Results available

Circuitry-Guided Smoking Cessation in Schizophrenia

NCT03281629
View directory record Official record
Conditions
Smoking Cessation, Nicotine Addiction, Schizophrenia
Interventions
Active TMS stimulation, Sham TMS stimulation
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 18, 2023 · Synced Oct 24, 2026, 6:06 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Beta-Adrenergic Modulation of Drug Cue Reactivity

NCT05587361
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
Interventions
Propranolol, Nicotine Patch, Placebo Propranolol, Placebo Patch
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Phase 3 Interventional

Naltrexone Augmentation of Nicotine Patch Therapy - 1

NCT00218153
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Naltrexone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

NCT03072628
View directory record Official record
Conditions
Nicotine Dependence
Interventions
e-cig with nicotine, e-cig without nicotine, nicotine inhaler, sham control
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study

NCT01943994
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Psilocybin-assisted treatment, Nicotine Replacement Therapy (NRT)
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 65 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 24, 2026, 6:06 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt

NCT00571805
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varencline, placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2015 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study

NCT04646174
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation, American Lung Association self-management strategies for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Phase 2 Interventional Results available

Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence

NCT01292642
View directory record Official record
Conditions
Cannabis Dependence, Nicotine Dependence
Interventions
Cognitive Behavioral Therapy, Nicotine Replacement Therapy
Behavioral · Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2013 · Synced Oct 24, 2026, 6:06 AM EDT
Withdrawn Not applicable Interventional

Korean Youth Smoking Cessation Study

NCT02021175
View directory record Official record
Conditions
Smoking
Interventions
Tailored CBME Therapy via Technology, Standard of Care
Behavioral · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
14 Years to 19 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Results available

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study

NCT04043728
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2021 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents

NCT04707911
View directory record Official record
Conditions
Vaping
Interventions
Social Media Intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years to 21 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Oct 24, 2026, 6:06 AM EDT
Withdrawn Phase 1 Interventional

Trial of Computerized MET for Adolescent Substance Use

NCT01784653
View directory record Official record
Conditions
Drug Abuse, Alcohol Abuse, Nicotine Dependence
Interventions
iMET, MET
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2017 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Incentive Programs for Female Substance Abusers Who Smoke - 3

NCT00064922
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Behavior Therapy
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
15 Years to 99 Years · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 24, 2026, 6:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomic Status Young Adult Smokers

NCT02974582
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Exposure to smoking advertising with coupon, Exposure to smoking advertising without coupons, Exposure to non health related images
Behavioral
Lead sponsor
National Institute on Minority Health and Health Disparities (NIMHD)
NIH
Eligibility
18 Years to 29 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Extinction Updating in Reconsolidation

NCT02154685
View directory record Official record
Conditions
Nicotine Addiction, Smoking Cessation
Interventions
Retrieval-Extinction, Non-Retrieval Extinction
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 2, 2015 · Synced Oct 24, 2026, 6:06 AM EDT
Not yet recruiting Not applicable Interventional

Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation

NCT07789496
View directory record Official record
Conditions
Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
Interventions
Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Phase 2 Interventional

Treatment to Quit Smoking

NCT00018161
View directory record Official record
Conditions
Smoking
Interventions
Mecamylamine, Nicotine Patch, Cigarette brand switching
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional

Mindfulness Training for Smoking Cessation

NCT01144689
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
Interventions
Mindfulness Training, Smoking Cessation Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 7, 2016 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Results available

Improving Tobacco Treatment Rates for Cancer Patients Who Smoke

NCT04738643
View directory record Official record
Conditions
Cancer, Tobacco Use, Smoking, Nicotine Dependence
Interventions
Tobacco Use Treatment Service and Varenicline Management
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
Not listed
Enrollment
685 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Smoking, Sex Hormones, and Pregnancy

NCT01811225
View directory record Official record
Conditions
Nicotine Dependence, Contraception
Interventions
Low-dose Progesterone, High-dose Progesterone
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 24, 2026, 6:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reactions to E-cigs and Alcohol

NCT03449017
View directory record Official record
Conditions
Alcohol Abuse, Nicotine Dependence Tobacco Product
Interventions
E-cig use
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Oct 24, 2026, 6:06 AM EDT