- Conditions
- Tobacco Dependence
- Interventions
- Very low nicotine content cigarettes, standard nicotine content cigarettes
- Other
- Lead sponsor
- Brown University
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 58 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2017
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
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Showing 1–24
of 433
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Nicotine Dependence
- Interventions
- Tolcapone, Sugar Pill
- Drug
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years to 45 Years · Female only
- Enrollment
- 36 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2019
- U.S. locations
- 1
- States / cities
- West Haven, Connecticut
- Conditions
- Nicotine Dependence
- Interventions
- Bupropion SR, Nicotine Patch, Placebo Patch and Placebo Pill
- Drug
- Lead sponsor
- Southern Illinois University Carbondale
- Other
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 197 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2013
- U.S. locations
- 1
- States / cities
- Carbondale, Illinois
- Conditions
- Nicotine Dependence
- Interventions
- Psilocybin-assisted treatment, Nicotine Replacement Therapy (NRT)
- Drug
- Lead sponsor
- Johns Hopkins University
- Other
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 82 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2008 – 2023
- U.S. locations
- 2
- States / cities
- Baltimore, Maryland
- Conditions
- Nicotine Dependence
- Interventions
- Internet-based smoking treatment, Individual Counseling, self-help
- Behavioral
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 207 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2006 – 2011
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Nicotine Dependence
- Interventions
- Tailored treatment, Standard Treatment
- Behavioral
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years to 64 Years · Female only
- Enrollment
- 28 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011 – 2012
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut
- Conditions
- Nicotine Dependence, Nicotine Withdrawal
- Interventions
- Progesterone, Placebo
- Drug
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 18 Years to 50 Years
- Enrollment
- 81 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2010 – 2021
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Smoking, Tobacco, Smoking (Tobacco) Addiction
- Interventions
- Cigarette 1, Cigarette 2, Patch 1, Patch 2
- Drug
- Lead sponsor
- University of Southern California
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 221 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2023
- U.S. locations
- 1
- States / cities
- Los Angeles, California
- Conditions
- Nicotine Dependence
- Interventions
- Intravenous Nicotine
- Drug
- Lead sponsor
- Mclean Hospital
- Other
- Eligibility
- 18 Years to 40 Years
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2005 – 2015
- U.S. locations
- 1
- States / cities
- Belmont, Massachusetts
- Conditions
- Smoking Cessation; Tobacco Dependence, E-Cig Use, Nicotine Dependence, Other Tobacco Product
- Interventions
- BREATHE Free Curriculum
- Behavioral
- Lead sponsor
- Augusta University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 90 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Augusta, Georgia
- Conditions
- Nicotine Dependence
- Interventions
- e-cig with nicotine, e-cig without nicotine, nicotine inhaler, sham control
- Other
- Lead sponsor
- University of California, Los Angeles
- Other
- Eligibility
- 21 Years to 45 Years
- Enrollment
- 148 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2022
- U.S. locations
- 1
- States / cities
- Los Angeles, California
- Conditions
- Vaping, Nicotine Dependence
- Interventions
- Varenicline, Placebo
- Drug
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 18 Years to 25 Years
- Enrollment
- 5 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Smoking Cessation
- Interventions
- Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches
- Combination Product · Drug
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 150 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Rochester, Minnesota
- Conditions
- Nicotine Dependence
- Interventions
- Brief Motivational Intervention, Contingency Management, Non-Contingent Reinforcement
- Behavioral
- Lead sponsor
- Brown University
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 1 participant
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Nicotine Dependence, Cigarettes
- Interventions
- Varenicline (VRN), N-Acetylcysteine (NAC), Placebo
- Drug
- Lead sponsor
- Medical University of South Carolina
- Other
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 67 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2020
- U.S. locations
- 1
- States / cities
- Charleston, South Carolina
- Conditions
- Second Hand Tobacco Smoke, Nicotine Dependence
- Interventions
- Ask, Advise, Refer, Telebased tobacco counseling, Telebased nutrition counseling, Mobile phone smoking cessation application, Mobile phone nutrition application, Nicotine polacrilex
- Behavioral · Device · Drug
- Lead sponsor
- Temple University
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 396 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2019
- U.S. locations
- 2
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Schizophrenia, Schizoaffective Disorder, Alcohol Dependence, Nicotine Dependence
- Interventions
- Varenicline, Placebo
- Drug
- Lead sponsor
- State University of New York - Upstate Medical University
- Other
- Eligibility
- 18 Years to 69 Years
- Enrollment
- 10 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2011
- U.S. locations
- 1
- States / cities
- Syracuse, New York
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking Reduction, Smoking, Cigarette, Smoking, Nicotine Dependence
- Interventions
- Clickotine®
- Device
- Lead sponsor
- Click Therapeutics, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 78 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Vaping, Vaping Teens, Nicotine Dependence
- Interventions
- QuitVaping, This is Quitting (TIQ)
- Behavioral
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 14 Years to 18 Years
- Enrollment
- 400 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Tobacco Use Disorder
- Interventions
- Very low nicotine content cigarettes
- Other
- Lead sponsor
- University of Vermont
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 775 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2019
- U.S. locations
- 2
- States / cities
- Baltimore, Maryland • Burlington, Vermont
- Conditions
- Alcohol Abuse, Nicotine Dependence Tobacco Product
- Interventions
- E-cig use
- Behavioral
- Lead sponsor
- Indiana University
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 35 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2018
- U.S. locations
- 1
- States / cities
- Indianapolis, Indiana
- Conditions
- Nicotine Withdrawal, Tobacco Abstinence
- Interventions
- tDCS, prefrontal cortex and parietal cortex
- Device
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 60 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011 – 2015
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut
- Conditions
- Smoking Cessation
- Interventions
- Brief Computer Motivational Interviewing for Smoking Cessation, Nutrition Control
- Behavioral
- Lead sponsor
- Butler Hospital
- Other
- Eligibility
- 18 Years to 70 Years
- Enrollment
- 76 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012 – 2014
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Nicotine Dependence
- Interventions
- Cognitive Behavioural Therapy, Contingency Management, Nicotine Transdermal Patch
- Behavioral · Drug
- Lead sponsor
- Yale University
- Other
- Eligibility
- 14 Years to 19 Years
- Enrollment
- 154 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2015
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut