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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:22 PM EST

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Showing 49–72 of 130 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Nicotine Replacement Therapy Clear all

Conditions: Tobacco Smoking
Interventions: Cigarettes, E-Cigarette, Nicotine Gum or Lozenge; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 264 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio

Conditions: Smoking Cessation
Interventions: Nicotine nasal spray, Smoking cessation counseling; Drug · Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 15 Years to 18 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking Cessation
Interventions: Telephone counseling, Nicotine patches, Incentive; Behavioral · Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 3,816 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Nicotine Dependence
Interventions: Nicotine patch - transdermal, placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 127 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder, Smoking Cessation
Interventions: Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT); Drug · Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 18 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions: Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification; Behavioral · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Initial Efficacy of Quit Line, Efficacy of Secondary Reengagement Intervention
Interventions: Rate reduction intervention, Recycling Group, Choice Group, Proactive QL; Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 614 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Lackland Air Force Base, Texas

Conditions: Growth Hormone Deficiency, Pediatric, hGH (Human Growth Hormone), Endocrine System Diseases, Hormones, Pituitary Diseases
Interventions: Once weekly subcutaneous injection of TransCon hGH, Once daily subcutaneous injection of Genotropin; Drug
Lead sponsor: Ascendis Pharma Endocrinology Division A/S; Industry
Eligibility: 3 Years to 12 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 16
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 13 more

Conditions: Tobacco Use Cessation
Interventions: proactive outreach (PRO), telephone counseling (TC), Nicotine replacement therapy (NRT), Usual care (UC); Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 2,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions: nicotine lozenge, nicotine patch; Drug
Lead sponsor: Fox Chase Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 642 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 10
States / cities: Washington D.C., District of Columbia • Miami Beach, Florida • Augusta, Georgia + 7 more

Conditions: Smoking Cessation, Mood Tolerance, Mood Management, Nicotine Replacement Therapy
Interventions: Mood Tolearance, Mood Management, Nicotine Replacement therapy; Behavioral · Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation
Interventions: nicotine; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Tobacco Use Disorder
Interventions: EHR alert; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence, Nicotine Withdrawal
Interventions: Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling; Drug · Behavioral
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking Cessation, HIV
Interventions: Combination Therapy, Standard Care Intervention; Other
Lead sponsor: dr. maria miguez; Other
Eligibility: 18 Years and older
Enrollment: 488 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Nicotine Dependence
Interventions: Transdermal nicotine patch; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 525 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Carbon Monoxide Measurement, Nicotine Lozenge, Oral Nicotine Pouch, Nicotine Patch, Survey Administration, Check-in Phone Calls; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Smoking Cessation
Interventions: Removal of Financial Barriers, Financial Incentives, Mobile Health Application; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 3,228 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 5
States / cities: Oakland, California • Detroit, Michigan • Danville, Pennsylvania + 2 more

Conditions: Smoking Cessation
Interventions: Expert System Only, Enhanced Expert System; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 298 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Cessation
Interventions: Nicotine Patch, Questionnaires, Pamphlet, Phone Counseling Sessions, Saliva Test, Smart phone; Drug · Behavioral · Other + 1 more
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cannabis Dependence, Nicotine Dependence
Interventions: Cognitive Behavioral Therapy, Nicotine Replacement Therapy; Behavioral · Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Smoking Cessation
Interventions: Questionnaires, Low Dose Computed Tomography Scan, Shared Decision Making + Video, Cessation Counseling, Quitline, Pharmacotherapy Discussion, Nicotine Patch, Anti-Smoking Drug, Tobacco Treatment Program, Carbon Monoxide (CO) Level Test; Behavioral · Procedure · Other + 1 more
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 50 Years and older
Enrollment: 630 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Cessation
Interventions: Varenicline, Nicotine Patch, Placebo Patch, Placebo Tablet, Questionnaires, Counseling Sessions, Lab Session, Saliva Test; Drug · Behavioral · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 204 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
Interventions: QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charlottesville, Virginia

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Methods Project 4: Clinical Trial - Amended

Nicotine Replacement and Counseling In Adolescents

A Randomized Trial of Medi-Cal Beneficiaries Calling the California Smokers' Helpline

Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging

Quit-Smoking Study for Native Hawaiians

Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment

Enhancing the Efficacy of Smoking Quit Line in the Military (AFIII Renewal)

A Phase 3 Trial of the Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD)

Offering Proactive Tobacco Treatment

Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking

Mood and Smoking: A Comparison of Smoking Cessation Treatments

Provoked Craving Relief Study by NRT

Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients

Overcoming Nicotine Dependence to Enable Quitting

Patch Study - Intervention for HIV Positive Smokers

An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence

Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia

Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

Smoking Reduction and Cessation Interventions for Chinese

Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study

Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence

Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer

Reward Sensitivity and Pharmacotherapy for Smoking Cessation

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid