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Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nightmares Clear all
Not listed Phase 2 Interventional

Carvedilol Versus Placebo for Treatment in Post Traumatic Stress Disorder (PTSD)

NCT01221792
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Carvedilol, Placebo
Drug
Lead sponsor
Columbia Northwest Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
3
States / cities
San Diego, California • Lake Charles, Louisiana • Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Jun 7, 2011 · Synced Sep 5, 2026, 3:10 PM EDT
Recruiting Not applicable Interventional

Restorative Early Sleep Treatment After the Emergency Department

NCT07121270
View directory record Official record
Conditions
Insomnia, Nightmares Associated With Trauma and Stress, Nightmares, PTSD - Post Traumatic Stress Disorder
Interventions
Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Insomnia and Nightmares, Sleep Education, Sleep Education enhanced with Nightmare Education
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Cognitive-Behavioral Therapy for Children With Nightmares as a Mediator of Suicide Risk (COMAA)

NCT05588739
View directory record Official record
Conditions
Nightmare
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
6 Years to 17 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NightWare and Cardiovascular Health in Adults With PTSD

NCT05365607
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness, Nightmare, Endothelial Dysfunction
Interventions
NightWare, Sham NightWare
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
22 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Remote Study of NightWare for PTSD With Nightmares

NCT03934658
View directory record Official record
Conditions
PostTraumatic Stress Disorder, Sleep Disorder, Stress Disorder, Sleep Initiation and Maintenance Disorders, Combat Disorders, Nightmares Associated With Chronic Post-Traumatic Stress Disorder, Nightmare, Nightmares, REM-Sleep Type
Interventions
NightWare Therapeutic System, NightWare Therapeutic System in Sham Mode
Device
Lead sponsor
NightWare
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Phase 4 Interventional

Prazosin Treatment for Combat Trauma PTSD (Post-Traumatic Stress Disorder) Nightmares and Sleep Disturbance

NCT00108420
View directory record Official record
Conditions
Stress Disorder, Post-Traumatic
Interventions
Prazosin
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Exposure, Relaxation, & Rescripting Therapy-Child

NCT02184026
View directory record Official record
Conditions
Post Trauma Nightmares, Traumatic Stress
Interventions
Exposure, Relaxation, & Rescripting Therapy-Child
Behavioral
Lead sponsor
University of Montana
Other
Eligibility
8 Years to 13 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Jun 19, 2016 · Synced Sep 5, 2026, 3:10 PM EDT
Recruiting Not applicable Interventional

Decreasing Nightmares in Adults With Narcolepsy

NCT06383806
View directory record Official record
Conditions
Narcolepsy, Narcolepsy Type 1, Narcolepsy With Cataplexy, Narcolepsy Without Cataplexy, Nightmare, Nightmare Disorder With Associated Other Sleep Disorder
Interventions
Imagery Rehearsal Therapy (IRT)
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Understanding Trauma Nightmares Using In-Home Measurement

NCT03974503
View directory record Official record
Conditions
Nightmares, Stress Disorders, Post-Traumatic, Actigraphy, Respiratory Sinus Arrhythmia, Veterans
Interventions
Exposure, Relaxation, and Rescripting Therapy, Sleep and Nightmare Management
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD

NCT02382848
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Bulimia Nervosa
Interventions
Prazosin, Placebo
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 15, 2019 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Efficacy of a Brief Nightmare Treatment for Veterans

NCT01220401
View directory record Official record
Conditions
Sleep Disorders, PTSD, Suicide
Interventions
exposure, relaxation, and rescription therapy
Behavioral
Lead sponsor
University of Tulsa
Other
Eligibility
18 Years to 99 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 29, 2019 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

NightWare Randomized Trial 02

NCT04040387
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Combat Disorders, Ptsd, Nightmare, Nightmares, REM-Sleep Type, Nightmare Disorder With Associated Non-Sleep Disorder
Interventions
NightWare Therapeutic System, Sham NightWare
Device
Lead sponsor
NightWare
Industry
Eligibility
22 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
4
States / cities
Bethesda, Maryland • Minneapolis, Minnesota • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings

NCT00974402
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Stress Disorders, Combat Disorders
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2014 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Nightmare Deconstruction and Reprocessing Pilot

NCT06904950
View directory record Official record
Conditions
Nightmare
Interventions
Nightmare Deconstruction and Reprocessing
Behavioral
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 64 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
San Diego, California • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Cognitive Behavioral Therapy for Insomnia vs. Exposure, Relaxation, and Rescripting Therapy

NCT03831412
View directory record Official record
Conditions
Insomnia, Nightmare, Trauma
Interventions
CBT-I, ERRT
Behavioral
Lead sponsor
University of Tulsa
Other
Eligibility
18 Years to 99 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 26, 2021 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD

NCT00532493
View directory record Official record
Conditions
PTSD, Sleep Disorders
Interventions
prazosin, placebo
Drug · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
15
States / cities
Loma Linda, California • Long Beach, California • Palo Alto, California + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

An Efficient Treatment for Posttraumatic Injury for Firefighters

NCT05950035
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Insomnia, Nightmare
Interventions
Written Exposure Therapy (WET), Cognitive Behavioral Therapy for Insomnia (CBTi), Cognitive Behavioral Therapy for Nightmares (CBTn), Waitlist
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Phase 4 Interventional

A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD

NCT01959022
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Doxazosin XL
Drug
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 69 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2016 · Synced Sep 5, 2026, 3:10 PM EDT
Not listed Not applicable Interventional

Dismantling Exposure, Relaxation, and Rescripting Therapy

NCT02236377
View directory record Official record
Conditions
Frequent Trauma-related Nightmares
Interventions
Exposure, Relaxation, and Rescripting Therapy
Behavioral
Lead sponsor
University of Tulsa
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 5, 2026, 3:10 PM EDT
Completed No phase listed Observational

The Effect of Nasal Continuous Positive Airway Pressure Treatment on PTSD Symptoms.

NCT01512771
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Anxiety, Nightmares, Unrefreshed Sleep
Interventions
CPAP
Other
Lead sponsor
Northport Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Northport, New York
Source: ClinicalTrials.gov public record
Updated Sep 24, 2014 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)

NCT00990106
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Combat Disorders, Sleep Disorders
Interventions
prazosin hydrochloride, placebo
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 22, 2018 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken)

NCT03795987
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Combat Disorders, Ptsd, Nightmare, Nightmares, REM-Sleep Type, Nightmare Disorder With Associated Non-Sleep Disorder
Interventions
NightWare Therapeutic System
Device
Lead sponsor
NightWare
Industry
Eligibility
22 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Sep 5, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Efficacy of Sleep Interventions for Posttraumatic Stress Disorder (PTSD)

NCT00393874
View directory record Official record
Conditions
Anxiety Disorders, Mood Disorders, Insomnia, Nightmares
Interventions
Behavioral Sleep Intervention, Prazosin, Placebo
Behavioral · Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 23, 2016 · Synced Sep 5, 2026, 3:10 PM EDT
Terminated Not applicable Interventional

The Nightmare Augmented Protocol for Treatment of Nightmares in Veterans With PTSD

NCT05120674
View directory record Official record
Conditions
PTSD
Interventions
NAP, CPT, ERRT, Cognitive Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
VA Eastern Kansas
Federal
Eligibility
18 Years to 99 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Leavenworth, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 14, 2021 · Synced Sep 5, 2026, 3:10 PM EDT