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Showing 1–24 of 79 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nitrous Oxide Clear all
Completed Phase 2 Interventional Accepts healthy volunteers

Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

NCT00000250
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
0% N2O, 40% N2O
Drug
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 32 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1993 – 1995
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Nitrous Oxide for External Cephalic Version

NCT03502915
View directory record Official record
Conditions
External Cephalic Version
Interventions
Nitrous Oxide, Placebo
Drug · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 29, 2019 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 2 Interventional Results available

Nitrous Oxide Analgesia Vaso-occlusive Crisis

NCT01891812
View directory record Official record
Conditions
Sickle Cell Disease, Vaso-occlusive Crisis
Interventions
Nitrous oxide 50%
Drug
Lead sponsor
Columbia University
Other
Eligibility
8 Years to 18 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Jul 23, 2026, 6:09 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Nitrous Oxide as Treatment for Fibromyalgia

NCT05357066
View directory record Official record
Conditions
Fibromyalgia, Central Neuropathic Pain
Interventions
Nitrous oxide gas for inhalation, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide for Pain Management During In-office Transcervical Sterilization

NCT02312739
View directory record Official record
Conditions
Contraception, Inhalation of Nitrous Oxide
Interventions
In-office Transcervical Sterilization (Essure®), Standard Oral pain medications, Intramuscular Ketorolac, Placebo pills, Oxygen, Nitrous Oxide
Procedure · Drug · Other
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 5, 2016 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Not applicable Interventional

Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14

NCT00000262
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
30% Nitrous oxide, 0.4% Sevoflurane, 0.2% sevoflurane, Placebo
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1999
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 4 Interventional Results available

Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia

NCT03171480
View directory record Official record
Conditions
Preeclampsia, Labor, Premature
Interventions
Monoket Pill, Placebo
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 3, 2022 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 2 Interventional

Nitrous Oxide for the Treatment of Major Depressive Disorder

NCT03869736
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
Nitrous Oxide, Placebo
Drug
Lead sponsor
Bayside Health
Government
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3

NCT00000251
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
30% N2O, 0.2% isoflurane, 0.4% isoflurane, 100% oxygen
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 32 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1994 – 1996
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Jul 23, 2026, 6:09 AM EDT
Terminated Phase 1 Interventional

Nitrous Oxide Vasodilation Healthy Adult Volunteers

NCT01785030
View directory record Official record
Conditions
Peripheral Vein Vasodilation
Interventions
50% Nitrous oxide
Drug
Lead sponsor
Columbia University
Other
Eligibility
19 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Jul 23, 2026, 6:09 AM EDT
Terminated No phase listed Observational

Effects of Nitrous Oxide on Intraocular Pressure

NCT00696189
View directory record Official record
Conditions
Post Operative Visual Loss
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Not applicable Interventional Results available

Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia

NCT00901394
View directory record Official record
Conditions
Cardiovascular Abnormalities
Interventions
B12-Folic Acid, nitrous oxide, Nitrous oxide (NO) and placebo, Placebo, oxygen nitrogen
Drug · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8

NCT00000256
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
20% N2O, 40% N2O, 60% N2O, 80% N2O
Drug
Lead sponsor
University of Chicago
Other
Eligibility
22 Years to 34 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 1996
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

NCT00000255
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
Nitrous oxide
Drug
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 37 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 1996
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Network-Level Effects of Nitrous Oxide in the Human Brain

NCT03435055
View directory record Official record
Conditions
Healthy
Interventions
Nitrous Oxide Gas for Inhalation
Drug
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 40 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 29, 2021 · Synced Jul 23, 2026, 6:09 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy

NCT05895383
View directory record Official record
Conditions
Procedural Pain, Pain Catastrophizing, Procedural Anxiety
Interventions
Nitrous oxide
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
21 Years to 85 Years · Male only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Jul 23, 2026, 6:09 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Inhaled Nitrous Oxide and Labor Analgesia

NCT01738672
View directory record Official record
Conditions
Labor Pain
Interventions
Inhaled nitrous oxide
Drug
Lead sponsor
Ya'aqov Abrams
Other
Eligibility
14 Years and older · Female only
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 20, 2017 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Not applicable Interventional Results available

Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study

NCT02145169
View directory record Official record
Conditions
Emergence Reaction, Procedural Sedation
Interventions
Inhaled Nitrous Oxide
Drug
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 2 Interventional Results available

Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies

NCT03283670
View directory record Official record
Conditions
Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant
Interventions
Nitrous Oxide 25%, Nitrous Oxide 50%, Placebo Gas
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 3, 2022 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops

NCT01925391
View directory record Official record
Conditions
Glaucoma, Intraocular Pressure, Anesthesia
Interventions
Tono-pen XL Applanation tonometer + Ocu-film +
Drug
Lead sponsor
University of Miami
Other
Eligibility
1 Year to 18 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Not applicable Interventional Results available

Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia

NCT00717574
View directory record Official record
Conditions
Deep Sedation, Anesthesia, General
Interventions
Sevoflurane group, Propofol group
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 30, 2017 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Phase 4 Interventional Results available

Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation

NCT00997126
View directory record Official record
Conditions
Sedation
Interventions
Propofol, Alfentanil
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 26, 2017 · Synced Jul 23, 2026, 6:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide for Pain Management of First Trimester Surgical Abortion

NCT02096575
View directory record Official record
Conditions
Abortion in First Trimester
Interventions
Nitrous oxide administration
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Jul 23, 2026, 6:09 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effect of Nitrous Oxide on Aggression.

NCT06118567
View directory record Official record
Conditions
Intermittent Explosive Disorder
Interventions
Nitrous oxide, Room Air
Drug
Lead sponsor
Ohio State University
Other
Eligibility
21 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Jul 23, 2026, 6:09 AM EDT