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ClinicalTrials.gov public records Last synced Sep 16, 2026, 4:54 AM EDT

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Showing 1–24 of 191 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Nodules Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Early Detection of Lung Cancer Via Bi-plane Correlation Chest Imaging

NCT00673283
View directory record Official record
Conditions
Lung Cancer, Metastatic Cancer in the Lungs
Interventions
bi-plane chest radiography
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 31, 2014 · Synced Sep 16, 2026, 4:54 AM EDT
Terminated Not applicable Interventional Results available

"Clinical Evaluation of Opto-Acoustic Tomography for Detection and Diagnostic Differentiation of Thyroid Nodules"

NCT03032198
View directory record Official record
Conditions
Feasibility Study for Thyroid Indication
Interventions
Imagio OA/US
Device
Lead sponsor
Seno Medical Instruments Inc.
Industry
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Greenwood Village, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Not applicable Interventional

Shared Decision Making in Patients With Thyroid Nodules

NCT02878044
View directory record Official record
Conditions
Thyroid Nodule, Thyroid Cancer
Interventions
Thyroid Decision Aid
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2022 · Synced Sep 16, 2026, 4:54 AM EDT
Recruiting No phase listed Observational

Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

NCT07226804
View directory record Official record
Conditions
Thyroid Nodules, Pulsed Field Ablation
Interventions
Questionnaire
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 16, 2026, 4:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Use of an In Vivo Optical Probe to Discriminate Benign From Malignant Thyroid Nodules

NCT01401855
View directory record Official record
Conditions
Cancer, Thyroid
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2016 · Synced Sep 16, 2026, 4:54 AM EDT
Completed No phase listed Observational

Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung

NCT04182815
View directory record Official record
Conditions
Pulmonary Nodule, Lung Cancer
Interventions
Robotic assisted bronchoscopy
Device
Lead sponsor
Auris Health, Inc.
Industry
Eligibility
21 Years and older
Enrollment
691 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
17
States / cities
Scottsdale, Arizona • Encinitas, California • Rancho Mirage, California + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 16, 2026, 4:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Randomized Controlled Trial of Voice on Children With Vocal Nodules

NCT01255735
View directory record Official record
Conditions
Vocal Fold Nodules
Interventions
Not listed
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
6 Years to 10 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
3
States / cities
Boston, Massachusetts • Philadelphia, Pennsylvania • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 1, 2016 · Synced Sep 16, 2026, 4:54 AM EDT
Not yet recruiting No phase listed Observational

Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization

NCT07768046
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
Interventions
Multiparametric chest MRI with diffusion-weighted imaging
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Phase 1 Interventional

Amino Acid Tracer (FACBC) Positron Emission Tomography for Lung Nodule

NCT01502670
View directory record Official record
Conditions
Lung Cancer
Interventions
18F-FACBC Radiotracer
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2013 · Synced Sep 16, 2026, 4:54 AM EDT
Recruiting Phase 1 Interventional

Pemefolacianine for IMI of Lung Cancer

NCT07772895
View directory record Official record
Conditions
Lung Cancer (Locally Advanced or Metastatic)
Interventions
Pemefolacianine Cohort 1 in Part A, Pemefolacianin Cohort 2 in Part B
Drug
Lead sponsor
Sunil Singhal
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 16, 2026, 4:54 AM EDT
Recruiting Not applicable Interventional

Decision Aid and Thyroid Nodules Management

NCT05264857
View directory record Official record
Conditions
Thyroid Nodule
Interventions
Thyroid Nodule Management Education
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Not applicable Interventional Results available

Preliminary Study 1 to Test the Effects of Ambulatory Voice Biofeedback

NCT03416829
View directory record Official record
Conditions
Vocal Fold Nodules
Interventions
Ambulatory voice biofeedback
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Sep 16, 2026, 4:54 AM EDT
Not listed Not applicable Interventional

Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease

NCT03090672
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Nodule, Degenerative Joint Disease, Tendinopathy, Tendinosis, Back Pain
Interventions
Normal Saline, Tissue Stromal Vascular Fraction, Platelet Rich Plasma, Cellular Stromal Vascular Fraction
Drug · Procedure · Biological
Lead sponsor
Robert W Alexander, MD
Other
Eligibility
18 Years to 90 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
North Attleboro, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 16, 2026, 4:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Liquid Biopsy for Early Non-small Lung Cancer Detection

NCT05462795
View directory record Official record
Conditions
Non Small-cell Lung Cancer
Interventions
Liquid biopsy for aberrant DNA methylation analysis - Indeterminate pulmonary nodule, Liquid biopsy for aberrant DNA methylation analysis - Known lung cancer for surgical resection, Liquid biopsy for aberrant DNA methylation analysis - Healthy volunteer, Liquid biopsy for aberrant DNA methylation analysis - Benign lung disease
Diagnostic Test
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Computer-Aided Lung Nodule Detection Software in Thoracic CT for Riverain Technologies LLC

NCT02440139
View directory record Official record
Conditions
Lung Cancer
Interventions
ClearRead CT Insight
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
55 Years to 77 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 3, 2021 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Phase 2 Interventional

Phase II Pre-operative Vitamin D Supplementation to Prevent Post-thyroidectomy Hypocalcemia

NCT01868750
View directory record Official record
Conditions
Thyroid Nodules, Hypocalcemia
Interventions
Calcitriol, Control Pill
Dietary Supplement
Lead sponsor
David Shonka, MD
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Sep 16, 2026, 4:54 AM EDT
Enrolling by invitation No phase listed Observational

Pressure-enabled Retrograde Occlusive Therapy With Embolization for Control of Thyroid Disease (PROTECT Registry): A Multicenter Registry

NCT06868459
View directory record Official record
Conditions
Hyperthyroidism; Goiter, Multinodular Goiter, Thyroid Nodules, Thyroid Disease, Hyperthyroidism, Toxic Multinodular Goiter
Interventions
Data Collection
Other
Lead sponsor
Sarasota Memorial Health Care System
Other
Eligibility
18 Years to 89 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Sarasota, Florida
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 16, 2026, 4:54 AM EDT
Active, not recruiting No phase listed Observational

Using e-Nose Technology to Identify Early Lung Cancer

NCT04734145
View directory record Official record
Conditions
Lung; Node, Lung Cancer
Interventions
Breathprinting test
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years to 85 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Phase 2 Interventional Results available

Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules

NCT02193828
View directory record Official record
Conditions
Dupuytren's Disease
Interventions
Collagenase clostridium histolyticum, Placebo
Biological
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
9
States / cities
Tucson, Arizona • Encinitas, California • Greenbrae, California + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2017 · Synced Sep 16, 2026, 4:54 AM EDT
Completed No phase listed Observational

Percutaneous Localization: Open-label Registry of Thoracic Surgery

NCT04066699
View directory record Official record
Conditions
Lung Lesion(s) Requiring Evaluation, Pulmonary Metastasis, Pulmonary Nodule, Solitary, Peripheral Lung Lesions
Interventions
Percutaneous localization of suspicious lung lesion(s) using electromagnetic navigation and tools.
Procedure
Lead sponsor
Veran Medical Technologies
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
5
States / cities
Lone Tree, Colorado • Bangor, Maine • Poughkeepsie, New York + 2 more
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Sep 16, 2026, 4:54 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

A Phase Ib/II Study of the Combination of BYL719 Plus AMG 479 in Adult Patients With Selected Solid Tumors

NCT01708161
View directory record Official record
Conditions
PIK3CA Mutated Advanced Solid Tumors, PIK3CA Amplified Advanced Solid Tumors
Interventions
BYL719, AMG 479
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
4
States / cities
Los Angeles, California • Boston, Massachusetts • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Sep 16, 2026, 4:54 AM EDT
Active, not recruiting No phase listed Observational

A Multicenter, Retrospective, Chart Review Study Evaluating the Impact and Utility of the Blood-Based Proteomic Integrated Classifier and Auto-Antibody Tests in the Real-World

NCT06728319
View directory record Official record
Conditions
Lung Nodules
Interventions
Not listed
Lead sponsor
Biodesix, Inc.
Industry
Eligibility
40 Years and older
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
5
States / cities
Brandon, Florida • Fort Walton Beach, Florida • Somerset, Kentucky + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Phase 1 Interventional

Intraoperative Imaging of Pulmonary Nodules by OTL38

NCT02602119
View directory record Official record
Conditions
Neoplasms
Interventions
OTL38
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Sep 16, 2026, 4:54 AM EDT
Completed Not applicable Interventional Results available

Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules

NCT04277455
View directory record Official record
Conditions
Thyroid Nodule
Interventions
Laser ablation of benign thyroid nodule
Device
Lead sponsor
Johnson Thomas
Other
Eligibility
18 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 2, 2024 · Synced Sep 16, 2026, 4:54 AM EDT