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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Non-Suicidal Self Injury Clear all
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Treatment for Non-Suicidal Self-Injury in Young Adults

NCT01018433
View directory record Official record
Conditions
Non-suicidal Self-injury
Interventions
T-SIB, Treatment as usual
Behavioral · Other
Lead sponsor
Fordham University
Other
Eligibility
18 Years to 29 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Jul 21, 2026, 4:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Observational Study to Compare Outcomes of Different Psychiatric Treatment of Suicidal Adolescents

NCT04625686
View directory record Official record
Conditions
Suicidal Ideation
Interventions
Mental Health Treatment
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Years to 18 Years
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
4
States / cities
Queens, New York • Cincinnati, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy for Nonsuicidal Self-injury

NCT03548402
View directory record Official record
Conditions
Nonsuicidal Self-Injury, Anxiety
Interventions
Acceptance and Commitment Therapy (ACT)
Behavioral
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2020 · Synced Jul 21, 2026, 4:41 PM EDT
Not listed Phase 3 Interventional

Self-Injury: Diagnosis and Treatment

NCT00065936
View directory record Official record
Conditions
Self-Injurious Behavior, Mental Retardation
Interventions
Naltrexone hydrochloride, Transcutaneous sensory nerve stimulation
Drug · Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
4 Years to 25 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Morganton, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Technology Enhanced Adolescent Mental Health (TEAM)

NCT05343039
View directory record Official record
Conditions
Nonsuicidal Self Injury, Alcohol Abuse, Vagus Nerve Stimulation
Interventions
Non-invasive Transcutaneous Nerve Stimulation (tVNS), No Intervention
Device
Lead sponsor
University of Notre Dame
Other
Eligibility
13 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
South Bend, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jul 21, 2026, 4:41 PM EDT
Recruiting Not applicable Interventional

Flourish in Schools Pilot Study

NCT07506525
View directory record Official record
Conditions
Psychological Distress, Suicidal Ideation
Interventions
Flourish
Device
Lead sponsor
Candice Biernesser
Other
Eligibility
11 Years to 21 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bay Village, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents

NCT01111734
View directory record Official record
Conditions
Deliberate Self Harm
Interventions
N-Acetylcysteine, fMRI
Dietary Supplement · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
13 Years to 21 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Jul 21, 2026, 4:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Efficacy of a Multi-level School Intervention for LGBTQ Youth

NCT05541406
View directory record Official record
Conditions
Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior, Sexual Minority Stress, Suicidality, Substance Use, Bullying, Harassment
Interventions
Proud & Empowered
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 20 Years
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
21
States / cities
El Monte, California • Glendale, California • Inglewood, California + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Jul 21, 2026, 4:41 PM EDT
Not yet recruiting Phase 2 Interventional

Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome

NCT07328529
View directory record Official record
Conditions
Aggressive Behavior in Fragile X Syndome
Interventions
SRX246, Placebo
Drug
Lead sponsor
Azevan Pharmaceuticals
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Sacramento, California • Chicago, Illinois • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Jul 21, 2026, 4:41 PM EDT
Withdrawn Not applicable Interventional

Interrupting Self-Harm Study

NCT03550521
View directory record Official record
Conditions
Nonsuicidal Self-injury
Interventions
Mindfulness
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
12 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Not applicable Interventional

Digital Mental Health Intervention for Nonsuicidal Self-Injury in Young Adults

NCT05325944
View directory record Official record
Conditions
Nonsuicidal Self Injury, Suicidal Ideation, Depression, Anxiety
Interventions
Self-guided digital intervention for NSSI, Digital intervention for NSSI with coaching, Active control
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 24 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Jul 21, 2026, 4:41 PM EDT
Terminated Phase 3 Interventional Results available

Ecopipam Treatment of Self-Injurious Behavior in Subjects With Lesch-Nyhan Disease

NCT01751802
View directory record Official record
Conditions
Lesch-Nyhan Disease, Self-injurious Behavior
Interventions
Ecopipam, Placebo
Drug
Lead sponsor
Emalex Biosciences Inc.
Industry
Eligibility
6 Years to 70 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 21, 2024 · Synced Jul 21, 2026, 4:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Manualized Assessment and Treatment Model of Challenging Behavior

NCT05928247
View directory record Official record
Conditions
Problem Behavior, Aggression, Self-Injury
Interventions
Functional Communication Training (FCT), Non-Contingent Reinforcement (NCR), Competing Items and Response Blocking, Research Units in Behavioral Intervention (RUBI) protocol
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
3 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Single-Session Intervention Targeting Self-Injurious Behavior in Adolescents

NCT04498143
View directory record Official record
Conditions
Nonsuicidal Self Injury, Self Hatred, Suicidal Thoughts, Suicide Attempts
Interventions
Project SAVE ("Stop Adolescent Violence Everywhere") SSI, Active Comparator: Supportive Therapy ("Share Your Feelings") SSI
Other
Lead sponsor
University of Denver
Other
Eligibility
13 Years to 16 Years
Enrollment
565 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Not applicable Interventional Results available

Digital Mental Health Service for Non-Treatment Seeking Young Adults

NCT04948268
View directory record Official record
Conditions
Depression, Anxiety, Suicidal Ideation
Interventions
Adaptive messaging intervention, Non-personalized messaging intervention, Coaching, Psychoeducational links
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 25 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 21, 2026, 4:41 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Dialectical Behavioral Therapy in Juvenile Justice

NCT05583279
View directory record Official record
Conditions
Non-Suicidal Self Injury, Suicide, Self-harm, Emotion Regulation
Interventions
Dialetical Behavioral Therapy for Adolescents
Behavioral
Lead sponsor
The Catholic University of America
Other
Eligibility
10 Years to 21 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Phase 2 Interventional Results available

Rapalogues for Autism Phenotype in TSC: A Feasibility Study

NCT01929642
View directory record Official record
Conditions
Tuberous Sclerosis Complex, Self-injury, Autism
Interventions
Sirolimus, Everolimus
Drug
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
2 Years to 30 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 28, 2021 · Synced Jul 21, 2026, 4:41 PM EDT
Recruiting Not applicable Interventional

Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

NCT07224165
View directory record Official record
Conditions
Nonsuicidal Self-injury, Depression, Anxiety
Interventions
App-based digital mental health intervention for adolescent NSSI, App-based delivery of healthy living psychoeducational materials
Device
Lead sponsor
Northwestern University
Other
Eligibility
14 Years to 18 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Phase 1 Interventional Results available

Interpersonal Psychotherapy for Depressed Adolescents Engaging in Non-suicidal Self-injury

NCT00401102
View directory record Official record
Conditions
Depression, Self-injurious Behavior
Interventions
Interpersonal Psychotherapy for Depressed Adolescents
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
12 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2013 · Synced Jul 21, 2026, 4:41 PM EDT
Enrolling by invitation Not applicable Interventional

Core Competency Model for Corrections

NCT06359574
View directory record Official record
Conditions
Knowledge, Attitudes, Practice
Interventions
Core Competency Model for Corrections (CCM-C) Self-Directed Violence Prevention Training
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Conditioning Paradigm to Increase Affinity for Sacredness of Life

NCT05541900
View directory record Official record
Conditions
Suicidal Ideation, Suicide, Attempted, Suicide and Self-harm, Non-suicidal Self-injury
Interventions
TEC-Sacredness, TEC-Control
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 20, 2022 · Synced Jul 21, 2026, 4:41 PM EDT
Recruiting Phase 2 Interventional

Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism

NCT07091279
View directory record Official record
Conditions
Autism Spectrum Disorder, Challenging Behaviour, Aggression, Severe Disruptive Behaviour Disorders, Self-injury
Interventions
Propranolol, Placebo
Drug
Lead sponsor
Jeremy Veenstra-vanderweele
Other
Eligibility
12 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Staten Island, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 21, 2026, 4:41 PM EDT
Completed Not applicable Interventional

Treatment Study for Non-Suicidal Self-Injury

NCT02060448
View directory record Official record
Conditions
Self Injurious Behavior Without Suicidal Intent
Interventions
Emotion awareness training, Cognitive reappraisal
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Jul 21, 2026, 4:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

A Study Examining Adolescents With Non-Suicidal Self-Injury

NCT02947308
View directory record Official record
Conditions
Self-Injurious Behavior, Deliberate Self-Harm
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
12 Years to 16 Years · Female only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
3
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Jul 21, 2026, 4:41 PM EDT