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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Non-healing Diabetic Foot Ulcer Clear all
Not listed Not applicable Interventional

Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers

NCT06028386
View directory record Official record
Conditions
Non-healing Wound, Diabetic Foot Ulcer
Interventions
AC5® Advanced Wound System, Fibracol Plus Collagen Dressing
Device
Lead sponsor
Arch Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Greenville, North Carolina • Circleville, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 10, 2023 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Not applicable Interventional

Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers

NCT05797285
View directory record Official record
Conditions
Ulcer Healing, Diabetic Foot Ulcer
Interventions
human keratin graft
Device
Lead sponsor
ProgenaCare Global, LLC
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
3
States / cities
Miami, Florida • Frederick, Maryland • Salem, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Jun 10, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.

NCT06437028
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Dual-layer perinatal tissue allograft, Three-layer fenestrated perinatal tissue allograft, Standard of care
Other
Lead sponsor
Samaritan Biologics
Industry
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Monroe, North Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Jun 10, 2026, 4:04 AM EDT
Not listed Not applicable Interventional

Effectiveness of Vaporous Hyperoxia Therapy (VHT) in the Treatment of Chronic Diabetic Foot Ulcers

NCT04210609
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Vaporous Hyperoxia Therapy
Device
Lead sponsor
Vaporox
Industry
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Castle Rock, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Not applicable Interventional

Prospective, Comparitive, Randomized Study of Allograft Versus Skin Substitute in Non-healing Diabetic Foot Ulcers

NCT02870816
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Tissue Engineered Skin Substitute, Offloading, Amnionic Membrane Graft
Procedure · Device
Lead sponsor
Professional Education and Research Institute
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
3
States / cities
Martinsville, Virginia • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Phase 3 Interventional

Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU II)

NCT04450693
View directory record Official record
Conditions
Diabetic Foot Infection, Non-healing Wound, Non-healing Diabetic Foot Ulcer
Interventions
TTAX01, Standard care
Biological · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
16
States / cities
Guntersville, Alabama • Tucson, Arizona • Los Angeles, California + 12 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jun 10, 2026, 4:04 AM EDT
Terminated Phase 1 Interventional

Multiple Applications of ExpressGraft-C9T1 Skin Tissue as a Treatment for Diabetic Foot Ulcers

NCT04134143
View directory record Official record
Conditions
Diabetes, Diabetic Foot Ulcer, Non-healing Wound
Interventions
ExpressGraft-C9T1 Skin Tissue
Biological
Lead sponsor
Stratatech, a Mallinckrodt Company
Industry
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
4
States / cities
Phoenix, Arizona • Fresno, California • San Francisco, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Jun 10, 2026, 4:04 AM EDT
Recruiting Phase 4 Interventional

A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL

NCT07172893
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Interventions
DermaBind TL
Biological
Lead sponsor
HealthTech Wound Care
Industry
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
10
States / cities
DeLand, Florida • Palm Beach Gardens, Florida • Sweetwater, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Jun 10, 2026, 4:04 AM EDT
Terminated Not applicable Interventional Results available

A Comparison of an Investigational Dressing to Tegaderm Matrix Wound Dressing in the Management of Diabetic Foot Ulcers

NCT01013792
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
Wound Dressing
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
6
States / cities
Montgomery, Alabama • Castro Valley, California • Bay Pines, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Jun 10, 2026, 4:04 AM EDT
Not listed Not applicable Interventional

Effectiveness of Aurix Therapy in Diabetic Foot Ulcers

NCT02352480
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Aurix
Device
Lead sponsor
Nuo Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
20
States / cities
Arcadia, California • Montebello, California • Visalia, California + 14 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Jun 10, 2026, 4:04 AM EDT
Terminated Phase 3 Interventional

Phase 3 Study Evaluating Efficacy and Safety of DSC127 Compared With Vehicle and With Standard-of-care in Diabetic Foot Ulcers

NCT01849965
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
DSC127, placebo vehicle gel, Standard of Care gel, Aquasite
Drug
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
33
States / cities
Mesa, Arizona • Phoenix, Arizona • Castro Valley, California + 25 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Jun 10, 2026, 4:04 AM EDT
Not listed No phase listed Observational

Comparing Wound Area Reduction of Non-healing DFUs Using MolecuLight i:X Versus Standard of Care

NCT04207099
View directory record Official record
Conditions
Non Healing Diabetic Foot Ulcer
Interventions
MolecuLight i:X Imaging Device
Device
Lead sponsor
MolecuLight Inc.
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Vista, California • Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Jun 10, 2026, 4:04 AM EDT
Terminated Not applicable Interventional

Effectiveness of AutoloGel Therapy in Diabetic Foot Ulcers

NCT01816633
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
AutoloGel
Device
Lead sponsor
Cytomedix
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Arcadia, California • Cumming, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 20, 2016 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Phase 3 Interventional Results available

VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic

NCT01450943
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
SECONDARY dressing gauze and tape, debridement, irrigation, Dermagraft, Oasis
Device · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Jun 10, 2026, 4:04 AM EDT
Terminated Phase 4 Interventional

RESPOND Restoring Equilibrium and Wound Stimulation to Promote Healing Of Non-healing DFUs

NCT01608776
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
MIST Therapy, SOC - Standard of Care
Device · Other
Lead sponsor
Celleration, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2014 · Synced Jun 10, 2026, 4:04 AM EDT
Terminated Not applicable Interventional Results available

Debritom - Micro Water Jet Technology and Wound Healing

NCT04240574
View directory record Official record
Conditions
Diabetic Foot Ulcer, Non-healing Wound, Non-Healing Ulcer of Skin, Venous Leg Ulcer, Venous Ulcer
Interventions
Debritom
Device
Lead sponsor
Stephanie Wu
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
North Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 26, 2023 · Synced Jun 10, 2026, 4:04 AM EDT
Not listed Not applicable Interventional

A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Non-Healing Diabetic Foot Ulcers

NCT02312596
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
PRP Concepts Fibrin Bio-Matrix, Usual and Customary Practice
Device · Other
Lead sponsor
PRP Concepts, LLC
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 12, 2021 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Not applicable Interventional

Non-healing Diabetic Foot Ulcers (DFU) Treated With SoC With or Without NEOX®CORD 1K

NCT02707406
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
NEOX®CORD 1K, standard of care
Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
19
States / cities
Carlsbad, California • Castro Valley, California • Fair Oaks, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2019 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Not applicable Interventional

A Prospective Trial of Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AC

NCT06511596
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
BR-AC, Standard Care
Other
Lead sponsor
BioStem Technologies
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
11
States / cities
San Francisco, California • Sylmar, California • Torrance, California + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jun 10, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

A Prospective Clinical Study to Evaluate the Effectiveness and Safety of Xcell Amnio MatrixTM (XAM) in the Management of Chronic Non-healing DFUs

NCT07116174
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU)
Interventions
Xcell Amnio Matrix, Standard of Care (SOC)
Biological · Drug
Lead sponsor
New Horizon Medical Solutions
Network
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Fresno, California • San Diego, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jun 10, 2026, 4:04 AM EDT
Not listed Not applicable Interventional

Randomized Clinical Study Assessing NuShield Versus Standard of Care in Diabetic Foot Ulcers

NCT03855514
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
NuShield
Other
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
9
States / cities
Carlsbad, California • Fresno, California • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Not applicable Interventional Results available

Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers

NCT06557122
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
SOC and Advanced Bioengineered Skin Substitute, SOC and Active Comparator
Device · Other
Lead sponsor
Encoll Corp
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Los Angeles, California • South Miami, Florida • Salem, Virginia
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Jun 10, 2026, 4:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Natrox Oxygen Wound Therapy on Non-healing Wounds and Implication of Remote Monitoring and Telehealth for Management in the Home.

NCT04746573
View directory record Official record
Conditions
Non-healing Wounds
Interventions
Natrox Topical Oxygen Therapy
Device
Lead sponsor
Inotec AMD Limited
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jun 10, 2026, 4:04 AM EDT
Completed Phase 2 Interventional Results available

Phase 2 Pilot Trial of Subjects With Complex Non-healing Diabetic Foot Ulcers Treated With Standard Care Plus Cryopreserved Umbilical Cord Allograft (TTAX01)

NCT03230175
View directory record Official record
Conditions
Non-healing Wound, Non-healing Diabetic Foot Ulcer, Diabetic Foot Infection
Interventions
TTAX01, Surgical resection and debridement, Systemic antibiotics, Off-loading
Biological · Procedure · Drug + 1 more
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
11
States / cities
Phoenix, Arizona • Sylmar, California • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Jun 10, 2026, 4:04 AM EDT