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Showing 1–24 of 81 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Noninvasive Ventilation Clear all
Not listed Not applicable Interventional

A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula

NCT04035460
View directory record Official record
Conditions
Hypoxemic Respiratory Failure
Interventions
Helmet, High Flow Nasal Oxygen
Device
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Sep 6, 2026, 1:59 PM EDT
Terminated No phase listed Observational

Registry to Evaluate INOmax in Newborn Babies With Pulmonary Hypertension

NCT03132428
View directory record Official record
Conditions
Pulmonary Hypertension of Newborn
Interventions
INOmax
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
27 Weeks to 40 Weeks
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
30
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Loma Linda, California + 27 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Sep 6, 2026, 1:59 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP

NCT01939067
View directory record Official record
Conditions
Respiratory Distress, Lung Injury
Interventions
Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Hours to 72 Hours
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional

Use of a 3D Printer to Make Custom Sleep Masks for Positive Airway Pressure Treatment

NCT02896751
View directory record Official record
Conditions
Sleep Apnea, Pediatric Sleep Apnea
Interventions
3D printed NIV mask
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
5 Years to 25 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Sep 6, 2026, 1:59 PM EDT
Withdrawn Not applicable Interventional

Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations

NCT01497691
View directory record Official record
Conditions
Asthma
Interventions
NIPPV (PALMtop PTV), Volumetric CO2 (NM3), USCOM
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
2 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 23, 2017 · Synced Sep 6, 2026, 1:59 PM EDT
Withdrawn Not applicable Interventional

The Impact of Interprofessional Training to Improve the Uptake of Noninvasive Ventilation in Patients Hospitalized With Severe COPD Exacerbation

NCT04206735
View directory record Official record
Conditions
Copd
Interventions
Interprofessional Education (IPE), Usual care
Other
Lead sponsor
Baystate Medical Center
Other
Eligibility
23 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Sep 6, 2026, 1:59 PM EDT
Terminated Not applicable Interventional

NIV for COPD: Hospital to Home

NCT04413643
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Noninvasive Ventilation
Interventions
Noninvasive Ventilation
Device
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

METEOR Think NIV Pilot

NCT04052542
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Traditional online continuing education, Interprofessional education, Just-in-time education
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1,328 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

EIT Assessment of Lung Volume and Tidal Distribution: A Comparison of Non-Invasive Ventilation Devices

NCT02930174
View directory record Official record
Conditions
Spontaneous Ventilation
Interventions
noninvasive positive pressure ventilation
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Results available

High Flow Therapy for the Treatment of Respiratory Failure in the ED

NCT02236559
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Noninvasive positive pressure ventilation (NIPPV), Vapotherm
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
5
States / cities
Athens, Georgia • Florence, South Carolina • Chattanooga, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Sep 6, 2026, 1:59 PM EDT
Withdrawn Phase 2 Interventional

Non Invasive Positive Pressure Ventilation in Status Asthmaticus

NCT01403428
View directory record Official record
Conditions
Status Asthmaticus
Interventions
Noninvasive positive pressure ventilation
Other
Lead sponsor
Southern Illinois University
Other
Eligibility
1 Year to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 11, 2014 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers

NCT03882723
View directory record Official record
Conditions
CO2 Clearance, Mask Comfort, Rebreathing Exhaled Gas
Interventions
Evaluated 4 masks used for NIV with mechanical ventilators
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Sep 6, 2026, 1:59 PM EDT
Terminated Not applicable Interventional Results available

The Use of High Frequency Oscillations With NIV in Hypercapnic COPD Participants

NCT02680639
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
BiPAP Synchrony ventilator
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2019 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Respiration Validation for CPM Device

NCT05445492
View directory record Official record
Conditions
Cardiopulmonary Disease
Interventions
CPM Device
Device
Lead sponsor
Analog Device, Inc.
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation

NCT02743936
View directory record Official record
Conditions
Mechanical Ventilation Pressure High
Interventions
Nasal cannula, Non-invasive positive pressure ventilation
Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2016 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Results available

Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation

NCT01925534
View directory record Official record
Conditions
Acute Respiratory Failure, Treatment With Noninvasive Positive Pressure Ventilation
Interventions
High-flow humidified nasal oxygen delivery system, Standard oxygen therapy
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • Winchester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 6, 2026, 1:59 PM EDT
Withdrawn Phase 1 Interventional

Early Noninvasive Positive Pressure Ventilation in Children With Status Asthmaticus

NCT01188473
View directory record Official record
Conditions
Status Asthmaticus
Interventions
NPPV plus standard of care
Other
Lead sponsor
Southern Illinois University
Other
Eligibility
1 Year to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite

NCT02859597
View directory record Official record
Conditions
Morbid Obesity, Noninvasive Ventilation, Deep Sedation
Interventions
High flow nasal cannula, Nasal Cannula
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2020 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Results available

Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

NCT01355978
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Airflow Obstruction, Chronic, Chronic Obstructive Airway Disease, Chronic Obstructive Lung Disease
Interventions
Noninvasive Open Ventilation System
Device
Lead sponsor
Breathe Technologies, Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
3
States / cities
Concord, California • San Diego, California • Ogden, Utah
Source: ClinicalTrials.gov public record
Updated Oct 11, 2016 · Synced Sep 6, 2026, 1:59 PM EDT
Terminated Not applicable Interventional Results available

Noninvasive NAVA Versus NIPPV in Low Birthweight Premature Infants

NCT03137225
View directory record Official record
Conditions
Noninvasive Ventilation, Low Birth Weight
Interventions
Neurally Adjusted Ventilatory Assist, Nasal Intermittent Positive Pressure Ventilation
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
Not listed
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 11, 2019 · Synced Sep 6, 2026, 1:59 PM EDT
Terminated No phase listed Observational

GentleFit Non-Invasive Ventilation (NIV) Interface Trial

NCT06833294
View directory record Official record
Conditions
Device Ineffective, Device Induced Injury
Interventions
GentleFit Mask, GentleFit Prong, Standard of Care Interface
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
38 Weeks to 3 Years
Enrollment
4 participants
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional

Work of Breathing During Non-invasive Ventilation in Premature Neonates

NCT02788110
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
Interventions
Noninvasive neurally adjusted ventilatory assist (NIV NAVA), Nasal intermittent positive pressure ventilation (NIPPV)
Other
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
Up to 12 Months
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced Sep 6, 2026, 1:59 PM EDT
Not listed Not applicable Interventional

Biphasic Ventilation Airway Management Clinical Trial

NCT03042598
View directory record Official record
Conditions
Intubation
Interventions
Biphasic Cuirass Ventilation
Device
Lead sponsor
University Medical Center of Southern Nevada
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Sep 6, 2026, 1:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Psychophysiological Effects of Controlled Respiration and Mindfulness

NCT05304000
View directory record Official record
Conditions
Stress, Physiological, Stress, Emotional, Insomnia
Interventions
Mindfulness Meditation, Cyclic Sighing Breathing, Box Breathing, Cyclic Hyperventilation with Retention
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Sep 6, 2026, 1:59 PM EDT