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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nonsuicidal Self Injury Clear all
Completed No phase listed Observational Accepts healthy volunteers Results available

A Study Examining Adolescents With Non-Suicidal Self-Injury

NCT02947308
View directory record Official record
Conditions
Self-Injurious Behavior, Deliberate Self-Harm
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
12 Years to 16 Years · Female only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
3
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Jun 10, 2026, 2:23 PM EDT
Terminated Phase 3 Interventional Results available

Ecopipam Treatment of Self-Injurious Behavior in Subjects With Lesch-Nyhan Disease

NCT01751802
View directory record Official record
Conditions
Lesch-Nyhan Disease, Self-injurious Behavior
Interventions
Ecopipam, Placebo
Drug
Lead sponsor
Emalex Biosciences Inc.
Industry
Eligibility
6 Years to 70 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 21, 2024 · Synced Jun 10, 2026, 2:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Basic and Applied Research on Extinction Bursts

NCT05925101
View directory record Official record
Conditions
Problem Behavior, Aggression, Self Injury
Interventions
Extinction-only condition, Rate-drop condition, Rate-hold condition, Magnitude-drop condition, Magnitude-hold condition, Quality-drop condition, Quality-hold condition, Rate-drop/quality-increase condition
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
3 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Phase 2 Interventional Results available

Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents

NCT04005053
View directory record Official record
Conditions
Self-Harm, Depression, Suicide
Interventions
N-acetyl cysteine, Placebo oral tablet
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
16 Years to 24 Years · Female only
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Jun 10, 2026, 2:23 PM EDT
Not yet recruiting Phase 2 Interventional

Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome

NCT07328529
View directory record Official record
Conditions
Aggressive Behavior in Fragile X Syndome
Interventions
SRX246, Placebo
Drug
Lead sponsor
Azevan Pharmaceuticals
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Sacramento, California • Chicago, Illinois • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Phase 2 Interventional Results available

Rapalogues for Autism Phenotype in TSC: A Feasibility Study

NCT01929642
View directory record Official record
Conditions
Tuberous Sclerosis Complex, Self-injury, Autism
Interventions
Sirolimus, Everolimus
Drug
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
2 Years to 30 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 28, 2021 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Single-Session Intervention Targeting Self-Injurious Behavior in Adolescents

NCT04498143
View directory record Official record
Conditions
Nonsuicidal Self Injury, Self Hatred, Suicidal Thoughts, Suicide Attempts
Interventions
Project SAVE ("Stop Adolescent Violence Everywhere") SSI, Active Comparator: Supportive Therapy ("Share Your Feelings") SSI
Other
Lead sponsor
University of Denver
Other
Eligibility
13 Years to 16 Years
Enrollment
565 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Jun 10, 2026, 2:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Manualized Assessment and Treatment Model of Challenging Behavior

NCT05928247
View directory record Official record
Conditions
Problem Behavior, Aggression, Self-Injury
Interventions
Functional Communication Training (FCT), Non-Contingent Reinforcement (NCR), Competing Items and Response Blocking, Research Units in Behavioral Intervention (RUBI) protocol
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
3 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents

NCT01111734
View directory record Official record
Conditions
Deliberate Self Harm
Interventions
N-Acetylcysteine, fMRI
Dietary Supplement · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
13 Years to 21 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Jun 10, 2026, 2:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Extensions of Resurgence as Choice

NCT05537610
View directory record Official record
Conditions
Problem Behavior, Aggression, Self-Injury
Interventions
CDT, Control
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
3 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jun 10, 2026, 2:23 PM EDT
Recruiting Not applicable Interventional

Self-Injury Treatment and Recovery in Veterans

NCT05969080
View directory record Official record
Conditions
Self-Injurious Behavior
Interventions
Treatment for Self-Injurious Behaviors, Treatment As Usual
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Phase 1 Interventional Results available

Interpersonal Psychotherapy for Depressed Adolescents Engaging in Non-suicidal Self-injury

NCT00401102
View directory record Official record
Conditions
Depression, Self-injurious Behavior
Interventions
Interpersonal Psychotherapy for Depressed Adolescents
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
12 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2013 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Conditioning Paradigm to Increase Affinity for Sacredness of Life

NCT05541900
View directory record Official record
Conditions
Suicidal Ideation, Suicide, Attempted, Suicide and Self-harm, Non-suicidal Self-injury
Interventions
TEC-Sacredness, TEC-Control
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 20, 2022 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Treatment for Non-Suicidal Self-Injury in Young Adults

NCT01018433
View directory record Official record
Conditions
Non-suicidal Self-injury
Interventions
T-SIB, Treatment as usual
Behavioral · Other
Lead sponsor
Fordham University
Other
Eligibility
18 Years to 29 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Jun 10, 2026, 2:23 PM EDT
Enrolling by invitation Not applicable Interventional

Core Competency Model for Corrections

NCT06359574
View directory record Official record
Conditions
Knowledge, Attitudes, Practice
Interventions
Core Competency Model for Corrections (CCM-C) Self-Directed Violence Prevention Training
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Not applicable Interventional Results available

Safety Planning in Juvenile Justice for Suicidal Youth

NCT03655470
View directory record Official record
Conditions
Suicidal Ideation, Suicide, Attempted, Nonsuicidal Self-injury
Interventions
Safety Planning, Standard care
Behavioral
Lead sponsor
Brown University
Other
Eligibility
12 Years to 18 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Treatment Study for Non-Suicidal Self-Injury

NCT02060448
View directory record Official record
Conditions
Self Injurious Behavior Without Suicidal Intent
Interventions
Emotion awareness training, Cognitive reappraisal
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Jun 10, 2026, 2:23 PM EDT
Withdrawn Not applicable Interventional

Interrupting Self-Harm Study

NCT03550521
View directory record Official record
Conditions
Nonsuicidal Self-injury
Interventions
Mindfulness
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
12 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Jun 10, 2026, 2:23 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Dialectical Behavioral Therapy in Juvenile Justice

NCT05583279
View directory record Official record
Conditions
Non-Suicidal Self Injury, Suicide, Self-harm, Emotion Regulation
Interventions
Dialetical Behavioral Therapy for Adolescents
Behavioral
Lead sponsor
The Catholic University of America
Other
Eligibility
10 Years to 21 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Digital Mental Health Intervention for Nonsuicidal Self-Injury in Young Adults

NCT05325944
View directory record Official record
Conditions
Nonsuicidal Self Injury, Suicidal Ideation, Depression, Anxiety
Interventions
Self-guided digital intervention for NSSI, Digital intervention for NSSI with coaching, Active control
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 24 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Technology Enhanced Adolescent Mental Health (TEAM)

NCT05343039
View directory record Official record
Conditions
Nonsuicidal Self Injury, Alcohol Abuse, Vagus Nerve Stimulation
Interventions
Non-invasive Transcutaneous Nerve Stimulation (tVNS), No Intervention
Device
Lead sponsor
University of Notre Dame
Other
Eligibility
13 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
South Bend, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jun 10, 2026, 2:23 PM EDT
Not listed Phase 3 Interventional

Self-Injury: Diagnosis and Treatment

NCT00065936
View directory record Official record
Conditions
Self-Injurious Behavior, Mental Retardation
Interventions
Naltrexone hydrochloride, Transcutaneous sensory nerve stimulation
Drug · Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
4 Years to 25 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Morganton, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Resurgence as Choice: Basic and Clinical Studies

NCT03423940
View directory record Official record
Conditions
Problem Behavior, Self-injury, Communication
Interventions
Functional communication training
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
3 Years to 19 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 2, 2024 · Synced Jun 10, 2026, 2:23 PM EDT
Completed Phase 4 Interventional Results available

Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder

NCT00834834
View directory record Official record
Conditions
Borderline Personality Disorder, Suicide
Interventions
Fluoxetine, DBT, Citalopram
Drug · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 17, 2017 · Synced Jun 10, 2026, 2:23 PM EDT