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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nonunion of Fracture Clear all
Completed No phase listed Observational

Observational, Non-interventional Use of LIPUS to Mitigate Fracture Non-union in Patients at Risk

NCT03382483
View directory record Official record
Conditions
Mitigation of Fracture Non-union in Patients at Risk
Interventions
Low intensity pulsed ultrasound
Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
12,387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Jericho, New York
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Jul 22, 2026, 10:59 AM EDT
Not listed No phase listed Observational

NGS for Non-unions

NCT03937310
View directory record Official record
Conditions
Nonunion of Fracture
Interventions
Next-generation sequencing of swabs collected during surgery
Diagnostic Test
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Jul 22, 2026, 10:59 AM EDT
Completed Phase 4 Interventional

Evaluation of Surgical Treatment on Pain and Disability for Chronic, Non-healing Rib Fracture

NCT00774618
View directory record Official record
Conditions
Rib Fracture
Interventions
Resection with or without plate fixation
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 21, 2013 · Synced Jul 22, 2026, 10:59 AM EDT
Enrolling by invitation Not applicable Interventional

G7 Freedom Constrained Vivacit-E Liners

NCT05587244
View directory record Official record
Conditions
Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures, Femoral Neck Fractures, Avascular Necrosis, Dislocation, Hip
Interventions
Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 80 Years
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2038
U.S. locations
10
States / cities
Birmingham, Alabama • Los Angeles, California • Gainesville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 22, 2026, 10:59 AM EDT
Withdrawn No phase listed Observational

Evaluation of the Risk for Radiographic and Clinical Nonunion in Patients With Previous Bisphosphonates Therapy.

NCT01731535
View directory record Official record
Conditions
Non-union or Delayed Healing Fractures
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
60 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 11, 2015 · Synced Jul 22, 2026, 10:59 AM EDT
Terminated No phase listed Observational

Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System

NCT06400732
View directory record Official record
Conditions
Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur, Fracture Nonunion, Fracture of Tibia, Limb Deformity, Limb Fracture, Limb Defect, Limb Asymmetry
Interventions
Fitbone Transport and Lengthening System
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
9
States / cities
Los Angeles, California • Orange, California • Atlanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 22, 2026, 10:59 AM EDT
Not listed Not applicable Interventional

Plating Clavicle Fractures

NCT00871468
View directory record Official record
Conditions
Clavicle Fracture, Non Union/Malunion
Interventions
superior plate, anterior-inferior plate
Procedure
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
2
States / cities
El Paso, Texas • Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Jul 22, 2026, 10:59 AM EDT
Not listed Phase 3 Interventional

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures

NCT05000281
View directory record Official record
Conditions
Tibia Fracture
Interventions
Ibuprofen
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Jul 22, 2026, 10:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Treatment of Type II Odontoid Fractures Among the Elderly

NCT00266929
View directory record Official record
Conditions
Neck Injuries, Spinal Injuries
Interventions
surgical, conservative treatment
Procedure
Lead sponsor
AOSpine North America Research Network
Network
Eligibility
64 Years and older
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
14
States / cities
Atlanta, Georgia • Indianapolis, Indiana • Kansas City, Kansas + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2017 · Synced Jul 22, 2026, 10:59 AM EDT
Recruiting No phase listed Observational

Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care

NCT04299022
View directory record Official record
Conditions
Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited, Fracture, Tibial, Fracture of Femur, Fracture Arm
Interventions
Vivigen Cellular Bone Matrix
Other
Lead sponsor
LifeNet Health
Industry
Eligibility
Not listed
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
Orlando, Florida • Jersey City, New Jersey • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Jul 22, 2026, 10:59 AM EDT
Completed Not applicable Interventional Results available

Distal Targeter vs Free-hand

NCT05613257
View directory record Official record
Conditions
Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia, Nonunion of Fracture of Femur (Diagnosis), Tibia Fracture
Interventions
Distal targeting jig, Free-hand/perfect circles technique
Device · Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Jul 22, 2026, 10:59 AM EDT
Completed No phase listed Observational

Serum-Protein-Based Indices for the Progression of Fracture Healing and Nonunion

NCT05143476
View directory record Official record
Conditions
Humerus Fractures
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jul 22, 2026, 10:59 AM EDT
Completed Not applicable Interventional Results available

The Effect of Hypovitaminosis D and Vitamin D Supplementation on Fracture Nonunion Rates

NCT01691833
View directory record Official record
Conditions
Hypovitaminosis D
Interventions
Vitamin D, Placebo
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Jul 22, 2026, 10:59 AM EDT
Not listed Not applicable Interventional

Intramedullary Bone Grafting for Open Tibial Shaft Fractures

NCT03891888
View directory record Official record
Conditions
Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
Interventions
Intramedullary Bone Graft
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jul 22, 2026, 10:59 AM EDT
Recruiting No phase listed Observational

Exactech Proximal Humerus Fracture Plate System Post Market Clinical Follow-up

NCT05703958
View directory record Official record
Conditions
Proximal Humeral Fracture, Fracture Dislocation, Non-Union Fracture
Interventions
Not listed
Lead sponsor
Exactech
Industry
Eligibility
21 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2034
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Jul 22, 2026, 10:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

BBOT: Bacterial Burden in Ortho Trauma Procedures

NCT03126448
View directory record Official record
Conditions
Orthopaedic Trauma Infections
Interventions
Highly Sensitive Assays
Diagnostic Test
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Jul 22, 2026, 10:59 AM EDT
Terminated Not applicable Interventional Results available

A Double-Blind Study on Adjunctive Use of PEMF in the Treatment of 5th Metatarsal Non-Union Fractures

NCT00586170
View directory record Official record
Conditions
Nonunion of Fracture of Fifth Metatarsal
Interventions
EBI Bone Healing System, Placebo Device, Surgery
Device · Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
2
States / cities
Newark, New Jersey • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced Jul 22, 2026, 10:59 AM EDT
Not yet recruiting Not applicable Interventional

Allograft vs. Autograft Nonunion

NCT07310082
View directory record Official record
Conditions
Nonunion Fracture
Interventions
Autograft, Allograft
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jul 22, 2026, 10:59 AM EDT
Recruiting Phase 3 Interventional

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

NCT05699174
View directory record Official record
Conditions
Infections, Infected Wound, Nonunion of Fracture, Injury Leg, Amputation, Internal Fixation; Complications, Infection or Inflammation, Fracture, Lower Extremity Fracture, Antibiotic Side Effect
Interventions
Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
13
States / cities
Indianapolis, Indiana • Baltimore, Maryland • Minneapolis, Minnesota + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 22, 2026, 10:59 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

Tibial Delayed Healing Pivotal Clinical Trial

NCT01016067
View directory record Official record
Conditions
Tibial Delayed Healing
Interventions
INFUSE/MASTERGRAFT, Autograft bone
Device · Procedure
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
21 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
16
States / cities
Denver, Colorado • Fort Lauderdale, Florida • Jacksonville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2015 · Synced Jul 22, 2026, 10:59 AM EDT
Enrolling by invitation No phase listed Observational

855303-RNA Biomarker Validation

NCT06872775
View directory record Official record
Conditions
Fractures, Bone
Interventions
Blood draws to assess RNA expression levels
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
7
States / cities
Sacramento, California • Bloomington, Indiana • Columbia, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jul 22, 2026, 10:59 AM EDT
Terminated Phase 1Phase 2 Interventional

Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures.

NCT00424567
View directory record Official record
Conditions
Fracture, Ununited, Pseudarthrosis
Interventions
Fracture surgery, Cultured Bone Marrow Tissue
Procedure · Drug
Lead sponsor
Vericel Corporation
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
4
States / cities
Des Plaines, Illinois • Ann Arbor, Michigan • Royal Oak, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Jul 22, 2026, 10:59 AM EDT
Completed Not applicable Interventional Results available

Clinical Study of the U-Plate Fracture Repair System to Treat Rib Fractures

NCT00556543
View directory record Official record
Conditions
Rib Fracture, Flail Chest
Interventions
U-plate fracture repair system
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 30, 2011 · Synced Jul 22, 2026, 10:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Relationships Between Vitamin D and Orthopedic Trauma

NCT04564625
View directory record Official record
Conditions
Fracture, Fracture Nonunion, Fractures, Bone, Vitamin D
Interventions
Vitamin D Assessment, Fracture
Other
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jul 22, 2026, 10:59 AM EDT