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Showing 1–24 of 410 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: OA Knee Pain Clear all
Completed Phase 2 Interventional

Study of OLT1177 Gel to Treat Moderate to Severe OA Knee Pain

NCT02104050
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Placebo Gel, OLT1177 Gel
Drug
Lead sponsor
Olatec Therapeutics, Inc.
Industry
Eligibility
45 Years to 80 Years
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
13
States / cities
Birmingham, Alabama • Milford, Connecticut • DeLand, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Sep 13, 2026, 10:36 PM EDT
Terminated Phase 2 Interventional Results available

A Study Of The Safety And Efficacy Of PF-04191834 In Patients With Osteoarthritis Of The Knee

NCT01147458
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
PF-04191834, PF-04191834 placebo, Naproxen placebo, Naproxen
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
25
States / cities
Peoria, Arizona • Phoenix, Arizona • Anaheim, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2013 · Synced Sep 13, 2026, 10:36 PM EDT
Terminated Phase 2 Interventional Results available

A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain

NCT02192190
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
LY2951742, Placebo- oral, Placebo - SC, Celecoxib
Drug · Other
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years to 75 Years
Enrollment
268 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
38
States / cities
Birmingham, Alabama • Anaheim, California • San Diego, California + 31 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Not applicable Interventional Results available

Yoga for Managing Knee Osteoarthritis in Older Women: a Feasibility Study

NCT01832155
View directory record Official record
Conditions
Osteoarthritis, Knee, Quality of Life, Poor Quality Sleep, Physical Impairment
Interventions
Hatha Yoga
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
65 Years to 86 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Phase 2 Interventional Results available

Study of FX006 in Patients With Osteoarthritis of the Knee

NCT01487161
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
FX006, TCA IR
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Tucson, Arizona • Duncansville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Phase 2 Interventional

Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain

NCT02558439
View directory record Official record
Conditions
Osteoarthritis
Interventions
CNTX-4975, Placebo
Drug · Other
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
45 Years to 80 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
22
States / cities
Birmingham, Alabama • Tucson, Arizona • Anaheim, California + 18 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Sep 13, 2026, 10:36 PM EDT
Recruiting Phase 4 Interventional

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

NCT06245109
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Duloxetine, Celecoxib, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
41 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 13, 2026, 10:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chronic Knee Pain Study

NCT00776932
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
852 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Sep 13, 2026, 10:36 PM EDT
Recruiting Phase 2 Interventional

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

NCT06859164
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Interventions
Genicular Artery Embolization, Lipiodol, Simple angiogram
Procedure · Device
Lead sponsor
University of Chicago
Other
Eligibility
40 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 13, 2026, 10:36 PM EDT
Terminated Phase 2 Interventional Results available

A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)

NCT04814368
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
canakinumab, LNA043, Placebo to canakinumab
Biological · Other
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
40 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
5
States / cities
La Mesa, California • Clearwater, Florida • Sunrise, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Phase 1Phase 2 Interventional

Arthritis Ease Study

NCT05721352
View directory record Official record
Conditions
Knee Osteoarthritis, Chronic Pain, Kinesiophobia
Interventions
Virtual Reality Nature scene plus heart rate variability biofeedback phone application
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
45 Years to 74 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced Sep 13, 2026, 10:36 PM EDT
Not listed Phase 2 Interventional

Osteoarthritis of the Knee Pain Study Using a CBD and THC Sublingual Tablet

NCT04195269
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain
Interventions
Test Article
Drug
Lead sponsor
Pure Green
Industry
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
West Bloomfield, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 13, 2020 · Synced Sep 13, 2026, 10:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Genicular Radiofrequency Ablation for Unilateral Knee Arthroplasty Pain Management

NCT02925442
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
t-RFA, C-RFA, Control
Procedure
Lead sponsor
Lyman Medical Research Foundation, Inc.
Other
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Coeur d'Alene, Idaho • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Sep 13, 2026, 10:36 PM EDT
Terminated Not applicable Interventional Results available

Durolane Versus Phosphate Buffered Saline (PBS) in Knee Osteoarthritis

NCT01753830
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Durolane, PBS
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
40 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
25
States / cities
Anniston, Alabama • Mobile, Alabama • Phoenix, Arizona + 22 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms

NCT06693648
View directory record Official record
Conditions
Osteoarthritis of Knee, Osteoarthritis, Knee
Interventions
AMZ001 Diclofenac gel, Placebo gel
Drug
Lead sponsor
Amzell
Industry
Eligibility
40 Years to 85 Years
Enrollment
549 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
7
States / cities
Thousand Oaks, California • Hialeah, Florida • Longwood, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Not applicable Interventional Results available

Transcranial Direct Current Stimulation in Older Persons With Knee Pain (Knee Pain and tDCS): Randomized Pilot Study

NCT02512393
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
45 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 13, 2026, 10:36 PM EDT
Withdrawn Phase 4 Interventional

The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty

NCT06489626
View directory record Official record
Conditions
Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative
Interventions
Methylprednisolone 4 milligram Tab, Dexamethasone injection
Drug
Lead sponsor
F. Johannes Plate
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Phase 1Phase 2 Interventional

3VM for Treatment of Chronic Osteoarthritis Knee Pain

NCT03142178
View directory record Official record
Conditions
Arthritis, Degenerative
Interventions
Experimental: 3VM1001 active 2g Cream 3 times daily, Experimental: 3VM1001 active 3g Cream 3 times daily, Experimental: 3VM1001 active 3g Cream 4 times daily, Placebo: 3VM1001 vehicle 2g Cream 3 times daily, Placebo: 3VM1001 vehicle 3g Cream 3 times daily, Placebo: 3VM1001 vehicle 3g Cream 4 times daily
Drug
Lead sponsor
CDA Research Group, Inc.
Industry
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Sep 13, 2026, 10:36 PM EDT
Active, not recruiting Not applicable Interventional

INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE

NCT06700109
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Neural Ice, Triamcinolone acetate
Device · Drug
Lead sponsor
Brixton Biosciences, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
15
States / cities
Larkspur, California • Washington D.C., District of Columbia • Gainesville, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Not applicable Interventional

Digital Home-Exercise Therapy Application For Patients With Non-Surgical Knee Injuries

NCT04323267
View directory record Official record
Conditions
Knee Injuries, Knee Osteoarthritis, Patellofemoral Syndrome
Interventions
Limber Digital Application, Physical therapy Therapy
Device · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2020 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Not applicable Interventional

Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain

NCT04145011
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Cooled Radiofrequency, Standard Radiofrequency
Device
Lead sponsor
Avanos Medical
Other
Eligibility
21 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
7
States / cities
Altoona, Pennsylvania • Sewickley, Pennsylvania • State College, Pennsylvania + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Sep 13, 2026, 10:36 PM EDT
Recruiting No phase listed Observational

FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis

NCT07625150
View directory record Official record
Conditions
Patellofemoral Osteoarthritis, Knee Osteoarthritis, Knee Pain, Inflamation
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
50 participants
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 13, 2026, 10:36 PM EDT
Completed No phase listed Observational

Conjoint Analysis of Treatment Preferences for Osteoarthritis

NCT01003925
View directory record Official record
Conditions
Osteoarthritis
Interventions
Standard of care for osteoarthritis treatment, Conjoint Analysis for Osteoarthritis
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
65 Years to 95 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Sep 13, 2026, 10:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis

NCT03344913
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain, Physical Activity, Mitochondrial Pathology
Interventions
Walking
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 6, 2022 · Synced Sep 13, 2026, 10:36 PM EDT