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ClinicalTrials.gov public records Last synced Oct 11, 2026, 2:24 PM EDT

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Showing 145–168 of 254 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Obesity, Prediabetes Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fit and Trim for Diabetes Prevention

NCT02278939
View directory record Official record
Conditions
Pre-diabetes, Overweight, Obese
Interventions
Filipinos Fit and Trim Weight Loss Program
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
24 Years to 80 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2018 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional

Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology

NCT05523375
View directory record Official record
Conditions
Obesity, Diabetes Mellitus, Type 2, PreDiabetes
Interventions
Intensive Lifestyle Intervention
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
40 Years to 70 Years
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Living Partnership to Prevent Diabetes

NCT00631345
View directory record Official record
Conditions
Prediabetes, Obesity
Interventions
Group-Based Lifestyle Intervention (Phases 1 and 2), Individual Education Program (All Phases), Self-Directed Maintenance (Phase 3), Extended Group Maintenance (Phase 3)
Behavioral · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
301 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Phase 4 Interventional Results available

Cardiovascular Effects of GLP-1 Receptor Activation

NCT03101930
View directory record Official record
Conditions
Obesity, PreDiabetes
Interventions
Liraglutide, Sitagliptin, hypocaloric diet, Placebos, Exendin (9-39)
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vestibular Stimulation to Trigger Adipose Loss (VeSTAL) Clinical Trial

NCT03640286
View directory record Official record
Conditions
Obesity
Interventions
VeSTAL
Device
Lead sponsor
Neurovalens Ltd.
Industry
Eligibility
22 Years to 80 Years
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
3
States / cities
La Jolla, California • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional

Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients

NCT02551640
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Prediabetic State, Hypertension, Prehypertension, Obesity
Interventions
FeatForward App (on study smartphone)
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
Charlestown, Massachusetts • Revere, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Prevent in Underserved Populations

NCT02664064
View directory record Official record
Conditions
Prediabetes, Overweight, Obesity
Interventions
Prevent
Behavioral
Lead sponsor
Omada Health, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
227 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
3
States / cities
Los Angeles, California • San Fernando, California • Monroe, Washington
Source: ClinicalTrials.gov public record
Updated Mar 4, 2020 · Synced Oct 11, 2026, 2:24 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform

NCT05121844
View directory record Official record
Conditions
Weight Loss, Metabolic Syndrome, Pre-diabetes, Central Obesity, Glucose Intolerance, Metabolic Glucose Disorders
Interventions
Continuous Glucose Monitor Device
Device
Lead sponsor
Signos Inc
Industry
Eligibility
18 Years and older
Enrollment
31,187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 24, 2025 · Synced Oct 11, 2026, 2:24 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Clinical Utility of SUDOSCAN in the Pediatric Population

NCT02216201
View directory record Official record
Conditions
Childhood Obesity, Prediabetes, Diabetes
Interventions
Not listed
Lead sponsor
Impeto Medical
Industry
Eligibility
8 Years to 17 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2014 · Synced Oct 11, 2026, 2:24 PM EDT
Active, not recruiting Not applicable Interventional

Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial

NCT06976307
View directory record Official record
Conditions
Disabilities, Obesity and Overweight, Prediabetes
Interventions
High Carbohydrate Diet, Reduced Carbohydrate Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional

Pathobiology and Reversibility of Prediabetes in a Biracial Cohort

NCT02027571
View directory record Official record
Conditions
Prediabetes, Type 2 Diabetes, Obesity
Interventions
Intensive Lifestyle Intervention (ILI)
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 65 Years
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Oct 11, 2026, 2:24 PM EDT
Recruiting Not applicable Interventional

Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

NCT06055036
View directory record Official record
Conditions
Cardiometabolic Syndrome, Physical Inactivity, Hypertension, Type 2 Diabetes, PreDiabetes, Obesity, Cardiovascular Diseases, Smoking, Sleep, Hyperlipidemias, Diet, Healthy, Blood Pressure
Interventions
Black Impact Intervention
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Male only
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Effect of Cabergoline on Weight and Glucose Tolerance

NCT01395602
View directory record Official record
Conditions
Body Weight, Impaired Glucose Tolerance in Obese
Interventions
Cabergoline, placebo
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 14, 2015 · Synced Oct 11, 2026, 2:24 PM EDT
Terminated Not applicable Interventional Results available

Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome

NCT04105218
View directory record Official record
Conditions
Metabolic Syndrome, PreDiabetes, Hypertension, Obesity, Hyperlipidemias
Interventions
Exercise
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
19 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 11, 2026, 2:24 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Stanford Kids CAMP Study

NCT05380817
View directory record Official record
Conditions
Pre-diabetes, Obesity, Type-2 Diabetes Mellitus
Interventions
Remote Monitoring Program
Other
Lead sponsor
Stanford University
Other
Eligibility
5 Years to 13 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 19, 2022 · Synced Oct 11, 2026, 2:24 PM EDT
Withdrawn Not applicable Interventional

Isoleucine Addition Treatment Effects in a Controlled Diet Study

NCT07329088
View directory record Official record
Conditions
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight
Interventions
L-Isoleucine, Low-isoleucine diet
Dietary Supplement · Other
Lead sponsor
Jean L. Fry
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Dietary Habits on Metabolic Health

NCT02298790
View directory record Official record
Conditions
Overweight, Obesity, Prediabetes, Meals
Interventions
Meal schedule
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 60 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional

Technology-Supported Treatment of Sleep Apnea in Prediabetes

NCT04225507
View directory record Official record
Conditions
Sleep Apnea, PreDiabetes, Overweight or Obesity
Interventions
Diet and exercise coaching, CPAP Treatment
Behavioral · Other
Lead sponsor
University of Chicago
Other
Eligibility
20 Years to 65 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healthy Living Partnerships to Prevent Diabetes in Veterans Pilot Study

NCT02835495
View directory record Official record
Conditions
Pre-diabetes, Obesity
Interventions
HELP Vets Intervention, Individual Education Program
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Salisbury, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 24, 2020 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Phase 2 Interventional Results available

Metabolic Effects of Betaine Supplementation

NCT01950039
View directory record Official record
Conditions
Obesity, Dysglycemia
Interventions
Betaine, Placebo
Drug
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
21 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SWITCH Diets Study: Self-monitoring With Internet Technology to Choose Healthy Diets

NCT06245369
View directory record Official record
Conditions
Overweight and Obesity, Pre-diabetes
Interventions
learning modules (within app), SWITCH app (self-regulation features) - Experimental, SWITCH app (self-regulation features) - Comparator
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 21, 2025 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Active You: Feasibility of a Unique Physical Activity Program to Prevent Diabetes and Heart Disease

NCT04621045
View directory record Official record
Conditions
Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
Interventions
The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
40 Years to 70 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Beaver Falls, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2022 · Synced Oct 11, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Diabetes in the Deep South: Extending Partnerships and Adapting Interventions to Reach Rural Communities at High Risk.

NCT04343872
View directory record Official record
Conditions
Pre-diabetes
Interventions
Receive lifestyle modification alone, Metformin therapy
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Oct 11, 2026, 2:24 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Human Models of Selective Insulin Resistance: Alpelisib, Part I

NCT06354088
View directory record Official record
Conditions
Insulin Resistance, Prediabetic State, Overweight and Obesity, Non-Alcoholic Fatty Liver Disease
Interventions
Alpelisib 300 mg, Placebo, [1-13C] sodium acetate, [6,6-2H2] D-glucose, Mixed Meal Tolerance Test, Nestlé BOOST Plus
Drug · Diagnostic Test · Dietary Supplement
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 11, 2026, 2:24 PM EDT