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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Obstructive Pulmonary Function Clear all
Completed Phase 3 Interventional Results available

Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients

NCT00144339
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
tiotropium, placebo
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
40 Years and older
Enrollment
5,993 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
95
States / cities
Anniston, Alabama • Birmingham, Alabama • Jasper, Alabama + 82 more
Source: ClinicalTrials.gov public record
Updated May 19, 2014 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Not applicable Interventional

Abdominal Functional Electrical Stimulation to Reduce Hyperinflation in Chronic Obstructive Pulmonary Disease Patients

NCT02035228
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
Abdominal Stimulation - low / early, Abdominal stimulation - low/late, Abdominal Stimulation - low/full, Abdominal stimulation - med/early, Abdominal stimulation - med/late, Abdominal Stimulation - med/full, Abdominal Stimulation - high/early, Abdominal Stimulation - high/late, Abdominal Stimulation - high/full
Device
Lead sponsor
Liberate Medical
Industry
Eligibility
40 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Jul 22, 2026, 4:57 AM EDT
Completed No phase listed Observational

Functional Activity of Airway Eosinophils in Allergic Disease

NCT01026532
View directory record Official record
Conditions
Asthma
Interventions
Segmental Allergen Challenge
Biological
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 50 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic (PD) Profiles of 3 Doses of Fluticasone Furoate (FF)/GW642444 Inhalation Powder at the End of a 28-day Treatment Period in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Compared to Placebo

NCT01072149
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
Fluticasone Furoate (FF)/GW642444 Inhalation Powder, placebo
Drug · Device
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
40 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
8
States / cities
DeLand, Florida • Orlando, Florida • Madisonville, Kentucky + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 8, 2017 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Not applicable Interventional

Evaluating Asthma Exacerbation-induced Changes in Lung Function With a Home-based Spirometer

NCT03705325
View directory record Official record
Conditions
Asthma, Asthma Attack, Asthma, Allergic
Interventions
Spirobank Smart spirometer
Device
Lead sponsor
VitalFlo Inc.
Industry
Eligibility
12 Years to 21 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Participants With Severe Eosinophilic Asthma on Markers of Asthma Control

NCT02281318
View directory record Official record
Conditions
Asthma
Interventions
Mepolizumab, Placebo, SOC
Biological · Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
12 Years and older
Enrollment
556 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
24
States / cities
Birmingham, Alabama • Fresno, California • Long Beach, California + 20 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2018 · Synced Jul 22, 2026, 4:57 AM EDT
Recruiting Not applicable Interventional

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

NCT06390345
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overweight and Obesity
Interventions
FOCuSEd Integrated Intervention, Enhanced Usual Care
Other
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
5
States / cities
Boise, Idaho • Chicago, Illinois • Minneapolis, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Jul 22, 2026, 4:57 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impairments That Affect Correct Inhaler Use in COPD

NCT06135324
View directory record Official record
Conditions
COPD
Interventions
Not listed
Lead sponsor
COPD Foundation
Other
Eligibility
60 Years to 90 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
9
States / cities
Birmingham, Alabama • Chicago, Illinois • Burlington, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated May 10, 2025 · Synced Jul 22, 2026, 4:57 AM EDT
Withdrawn No phase listed Observational

Oral Contraceptives and Asthma Control

NCT00662051
View directory record Official record
Conditions
Asthma, Regulatory T Cell Function
Interventions
Not listed
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 8, 2013 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Phase 2 Interventional Results available

A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis

NCT04631016
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease (COPD), Chronic Bronchitis
Interventions
Tozorakimab, Placebo
Drug · Other
Lead sponsor
AstraZeneca
Industry
Eligibility
40 Years to 80 Years
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
16
States / cities
Sheffield, Alabama • Newport Beach, California • Newark, Delaware + 13 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 22, 2026, 4:57 AM EDT
Recruiting Phase 2 Interventional

A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma

NCT07525375
View directory record Official record
Conditions
Asthma
Interventions
GP MDI, BFF MDI, Placebo MDI
Combination Product
Lead sponsor
AstraZeneca
Industry
Eligibility
4 Years to 11 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
11
States / cities
Bakersfield, California • Long Beach, California • San Diego, California + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jul 22, 2026, 4:57 AM EDT
Completed No phase listed Observational

User-Friendly Spirometer and Mobile App for Self-Management and Home Monitoring of Asthma Patients

NCT03642418
View directory record Official record
Conditions
Asthma Acute, Asthma in Children, Asthma Chronic, Asthma Attack
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years to 15 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Jul 22, 2026, 4:57 AM EDT
Completed No phase listed Observational

The Effect of Obesity on Lung Functioning

NCT00284895
View directory record Official record
Conditions
Obesity, Asthma
Interventions
Not listed
Lead sponsor
National Jewish Health
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Not applicable Interventional

Prospective Study Comparing Different Modalities of Oxygen Delivery During Assessment of Functional Exercise Capacity

NCT00484562
View directory record Official record
Conditions
COPD
Interventions
Standard oxygen delivery system, Homefill oxygen delivery system, Helios oxygen delivery system, FreeStyle oxygen system
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Not listed
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 3, 2016 · Synced Jul 22, 2026, 4:57 AM EDT
Completed No phase listed Observational

Interleukin (IL)-13 as a Marker in Pediatrics Asthma

NCT00968305
View directory record Official record
Conditions
Asthma
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
8 Years to 15 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 27, 2009 · Synced Jul 22, 2026, 4:57 AM EDT
Not yet recruiting Not applicable Interventional

WearME-Pro Phase II: Remote Use Usability and Longitudinal Validation Study (Patch Form Factor).

NCT07430605
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
WearME-Pro Patch System, FDA-cleared handheld spirometer (reference comparator), Cardea SOLO ECG patch (optional subset; exploratory HR reference)
Device
Lead sponsor
LASARRUS Clinic and Research Center
Industry
Eligibility
21 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Baltimore, Maryland • Salisbury, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Jul 22, 2026, 4:57 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function

NCT01974154
View directory record Official record
Conditions
COPD, Smoking
Interventions
Cohort I, Cohort II
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Phase 2 Interventional

Evaluate the Safety and Efficacy of a 5-HT4 Agonist in Chronic Constipation (ACCORD Trial)

NCT00391820
View directory record Official record
Conditions
Chronic Constipation
Interventions
TD-5108
Drug
Lead sponsor
Alfasigma S.p.A.
Industry
Eligibility
18 Years to 64 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2025 · Synced Jul 22, 2026, 4:57 AM EDT
Completed No phase listed Observational

Evaluating the Use of a Device Called Impulse Oscillometry in Participants With Vocal Cord Disorders or Asthma

NCT05246930
View directory record Official record
Conditions
Breathing, Mouth, Lung Function Decreased, Vocal Cord Dysfunction, Laryngeal Obstruction, Asthma
Interventions
Impulse Oscillometer
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
43 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Not applicable Interventional Results available

Continuous Positive Airway Pressure to Improve Milder Obstructive Sleep Apnea

NCT00089752
View directory record Official record
Conditions
Lung Diseases, Sleep Apnea Syndromes, Hypertension
Interventions
Continuous Positive Airway Pressure (CPAP) Treatment, Sham CPAP device - CPAP device with pressure delivered <1 cm H20
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 100 Years
Enrollment
281 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
4
States / cities
Denver, Colorado • Atlanta, Georgia • Long Island City, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2017 · Synced Jul 22, 2026, 4:57 AM EDT
Withdrawn Not applicable Interventional

A Novel Unidirectional Face Mask During NPPV in COPD Patients

NCT00972868
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
A unidirectional face mask (Modified 'Respironics PerformaTrak' Mask)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Jul 22, 2026, 4:57 AM EDT
Completed Not applicable Interventional

Nutrition for Asthmatics with Obesity

NCT05222451
View directory record Official record
Conditions
Asthma, Obesity
Interventions
DGA Diet, MCT Diet, KETO Diet
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Jul 22, 2026, 4:57 AM EDT
Active, not recruiting Phase 2 Interventional

Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD

NCT05607719
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Bevespi, Bretzri
Drug
Lead sponsor
University of Miami
Other
Eligibility
40 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 22, 2026, 4:57 AM EDT
Withdrawn No phase listed Observational

The Ohio State University Asthma Registry

NCT00839748
View directory record Official record
Conditions
Asthma
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Jul 22, 2026, 4:57 AM EDT