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ClinicalTrials.gov public records Last synced Oct 12, 2026, 8:02 AM EDT

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Showing 145–168 of 760 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Obstructive Sleep Apnea/Hypopnea Syndrome Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Obstructive Sleep Apnea Treatment in Serious Mental Illness

NCT05457127
View directory record Official record
Conditions
Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
Interventions
Automatic Positive Airway Pressure (APAP)
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
40 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Oct 12, 2026, 8:02 AM EDT
Active, not recruiting No phase listed Observational

A Prospective Observational Cohort to Study the Genetics of Obstructive Sleep Apnea and Associated Co-Morbidities

NCT01857427
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Ulysses Magalang MD
Other
Eligibility
18 Years to 70 Years
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Not applicable Interventional

Autonomic Function in Obstructive Sleep Apnea

NCT00681161
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
continuous positive airway pressure (CPAP)
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
21 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 24, 2017 · Synced Oct 12, 2026, 8:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

IOA Preventing Occlusal Changes With MAD Use

NCT07103941
View directory record Official record
Conditions
Sleep Related Breathing Disorder, Snoring, Obstructive Sleep Apnea (OSA), Open Bite, Occlusal Changes, Tooth Migration, Posterior Open Bite
Interventions
AM Aligner, Exercise
Device · Behavioral
Lead sponsor
Isabel Moreno Hay
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 12, 2026, 8:02 AM EDT
Completed No phase listed Observational

The Effect of Positive Airway Pressure on Heart Rate Variability

NCT00289666
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years to 75 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Oct 12, 2026, 8:02 AM EDT
Withdrawn No phase listed Observational

Magnetic Resonance Imaging in Obstructive Sleep Apnea

NCT02207127
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
MRI, DISE, and Surgery
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 2Phase 3 Interventional

US Clinical Study of the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System to Treat Obstructive Sleep Apnea

NCT01211444
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
HGNS Treatment
Device
Lead sponsor
Apnex Medical, Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
4
States / cities
San Francisco, California • Indianapolis, Indiana • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Oct 12, 2026, 8:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluating Sleep Quality With Emerging Technologies

NCT06900530
View directory record Official record
Conditions
Snoring, Sleep Disturbances, Hypoxia, Obstructive Sleep Apnea (OSA)
Interventions
Not listed
Lead sponsor
Case Western Reserve University
Other
Eligibility
20 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 2 Interventional Results available

The Use of Heliox in Obstructive Sleep Apnea Syndrome

NCT02135900
View directory record Official record
Conditions
Obstructive Sleep Apnea Syndrome
Interventions
Heliox
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Staten Island, New York
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 1 Interventional Results available

A Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Participants With Moderate to Severe Obstructive Sleep Apnea, and in Adult and Elderly Participants With Moderate to Severe Chronic Obstructive Pulmonary Disease

NCT04647383
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Pulmonary Disease, Chronic Obstructive, Respiration Disorders
Interventions
Placebo, Lemborexant 10 mg
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
45 Years to 90 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
11
States / cities
Glendale, Arizona • San Diego, California • Brandon, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Not applicable Interventional

Continous Positive Airway Pressure (CPAP) Compliance Study

NCT01642160
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
additional educational material, Standard of care
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 7, 2013 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Not applicable Interventional Results available

Optiflow THRIVE for Delivery of Oxygen to Patients During Total Intravenous Anesthesia While Undergoing Radiology Procedures

NCT04171037
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Oxygen Therapy, Questionnaire Administration, Optiflow THRIVE
Procedure · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Oct 12, 2026, 8:02 AM EDT
Recruiting Not applicable Interventional

NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients

NCT06677151
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 12, 2026, 8:02 AM EDT
Terminated Phase 4 Interventional Results available

The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation

NCT02162433
View directory record Official record
Conditions
Adenotonsillar Hypertrophy, Obstructive Sleep Apnea, Tonsillitis, Adenoiditis
Interventions
Normal Saline, Dexmedetomidine
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
3 Years to 16 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Oct 12, 2026, 8:02 AM EDT
Active, not recruiting Not applicable Interventional

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

NCT03487185
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
Interventions
Continuous Positive Airway Pressure, Sleep Advice Control
Device · Other
Lead sponsor
The George Washington University Biostatistics Center
Other
Eligibility
18 Years and older · Female only
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
14
States / cities
Birmingham, Alabama • San Francisco, California • Chicago, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Not applicable Interventional

Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants

NCT03695900
View directory record Official record
Conditions
Apnea of Prematurity, Desaturation of Blood, Central Apnea, Periodic Breathing, Obstructive Apnea of Newborn
Interventions
Targeting SpO2 at 93-95%, Targeting SpO2 at 90-92%
Other
Lead sponsor
University of Miami
Other
Eligibility
Up to 18 Weeks
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 2 Interventional Results available

Impact of Oxytocin on Obstructive Sleep Apnea Induced Changes in Sleep

NCT03148899
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Oxytocin Intranasal Spray, Placebo Intranasal Spray
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

OA Therapy for Mouth-breathers Who Snore

NCT04876625
View directory record Official record
Conditions
Snoring, Mouth Breathing, Obstructive Sleep Apnea
Interventions
myTAP oral appliance plus mouth shield, myTAP oral appliance alone for first 4 weeks
Device
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 4 Interventional Results available

Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine

NCT04570150
View directory record Official record
Conditions
Anesthesia
Interventions
Sugammadex, Neostigmine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome

NCT00107848
View directory record Official record
Conditions
Narcolepsy, Sleep Apnea, Obstructive
Interventions
Modafinil
Drug
Lead sponsor
Cephalon
Industry
Eligibility
6 Years to 16 Years
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
55
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 45 more
Source: ClinicalTrials.gov public record
Updated May 9, 2014 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Pharmacological Activation of HMN for OSA

NCT03640052
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Placebo oral capsule, LTM1201L, LTM1201LN, LTM1201LB, LTM1201LD
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Phase 1Phase 2 Interventional Results available

DAW1033D in Obstructive Sleep Apnea

NCT03383887
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Placebo oral capsule, DAW1033D oral capsule
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Not applicable Interventional Results available

A Randomized Cross Over Trial of Two Treatments for Sleep Apnea in Veterans With Post-Traumatic Stress Disorder

NCT01569022
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
CPAP, MAD
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Nov 8, 2017 · Synced Oct 12, 2026, 8:02 AM EDT
Completed Not applicable Interventional Results available

Pediatric Nasal Mask Usability Study

NCT01154322
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Pixi pediatric mask
Device
Lead sponsor
ResMed
Industry
Eligibility
2 Years to 7 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
3
States / cities
Redwood City, California • Aurora, Colorado • Wallingford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 24, 2013 · Synced Oct 12, 2026, 8:02 AM EDT