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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Ocular Comfort Clear all
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of Gunnar Computer Glasses on Viewing Comfort and Performance

NCT02925884
View directory record Official record
Conditions
Dry Eye, Eye Strain, Visual Acuity, Color Perception
Interventions
Gunnar OTC Glasses
Device
Lead sponsor
Pacific University
Other
Eligibility
18 Years to 42 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Forest Grove, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Results available

Acute Comfort and Blur of Systane Ultra and Systane

NCT00748865
View directory record Official record
Conditions
Dry Eye
Interventions
Systane Ultra Lubricant Eye Drops, Systane Lubricant Eye Drops
Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

T30 for Astigmatism in Digital Device Users

NCT06266728
View directory record Official record
Conditions
Contact Lens Complication, Astigmatism, Refractive Errors
Interventions
Total30 for Astigmatism Contact Lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
2
States / cities
Pittsburg, Kansas • Coldwater, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Results available

Ocular Comfort and OCT Observation of Post Lens Clearance and Ocular Tissue Compression

NCT01423773
View directory record Official record
Conditions
Ocular Comfort
Interventions
Lotrafilcon A test contact lens, Lotrafilcon A control contact lens, Ultra-High Resolution Optical Coherence Tomographer (OCT)
Device
Lead sponsor
CIBA VISION
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 27, 2013 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Masked Comparison of a New PEG Based Artificial Tear and Optive for Comfort, Vision & Wear Time in Patients Wearing Contact Lenses

NCT00570843
View directory record Official record
Conditions
Comfort, Vision and Wear Time
Interventions
New PEG based artificial tear, Optive
Drug
Lead sponsor
Bp Consulting, Inc
Network
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 21, 2010 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

SteRilizing Eye SoLution to ImprovE Patient ComFort (RELIEF)

NCT05747430
View directory record Official record
Conditions
Retinal Disease
Interventions
IRX-101, Providone-Iodine
Drug
Lead sponsor
iRenix Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
7
States / cities
Greenwich, Connecticut • Madison, Mississippi • Erie, Pennsylvania + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 4 Interventional

Effectiveness of Systane PRO for Mild to Moderate Dry Eye Disease

NCT07639034
View directory record Official record
Conditions
Dry Eye Disease (DED)
Interventions
Systane Pro Topical Ophthalmic
Drug
Lead sponsor
Gordon Schanzlin New Vision
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Not yet recruiting Not applicable Interventional

The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage

NCT07223866
View directory record Official record
Conditions
Cataract and IOL Surgery, Cataract Surgery Anesthesia, Cataract Surgery Experience, Nuclear Cataract
Interventions
High IOP Setting, Low IOP Setting
Device
Lead sponsor
Matthew Rauen
Other
Eligibility
60 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Results available

Acute Comfort of Lubricant Eye Drops FID 112903

NCT00673855
View directory record Official record
Conditions
Dry Eye
Interventions
Lubricant Eye Drops FID 112903, Optive Lubricant Eye Drops
Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Mansfield, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Sep 3, 2026, 10:50 PM EDT
Completed No phase listed Observational Results available

A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs

NCT00823043
View directory record Official record
Conditions
Open-angle Glaucoma, Ocular Hypertension
Interventions
timolol hemihydrate, timolol maleate
Drug
Lead sponsor
Vistakon Pharmaceuticals
Industry
Eligibility
21 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2015 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Total30 Sphere Contact Lenses

NCT05183022
View directory record Official record
Conditions
Contact Lens Complication, Dry Eye
Interventions
Total30 Sphere Contact Lenses
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 45 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 15, 2022 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 1 Interventional

A Comparison of the Safety and Comfort of AC-170

NCT01495338
View directory record Official record
Conditions
Normal Ocular Health
Interventions
AC-170 0.17%, AC-170 0.24% (Formulation 1), AC-170 0.24% (Formulation 2), Olopatadine hydrochloride 0.2%/Tears Naturale II
Drug
Lead sponsor
Aciex Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2017 · Synced Sep 3, 2026, 10:50 PM EDT
Recruiting No phase listed Observational

Comfort and Vision With TOTAL30 Multifocal Lenses

NCT07284966
View directory record Official record
Conditions
Myopia, Presbyopia, Astigmatism
Interventions
TOTAL30 Multifocal
Device
Lead sponsor
Scripps Poway Eyecare and Optometry
Other
Eligibility
40 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Total30 For Contact Lens Dropouts

NCT06967298
View directory record Official record
Conditions
Dry Eye, Contact Lens Complication, Contact Lenses
Interventions
T30 Contact lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 4 Interventional

Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study)

NCT04018482
View directory record Official record
Conditions
Age-related Macular Degeneration, Diabetic Retinopathy, Diabetic Macular Edema
Interventions
Povidone Iodine, Hypochlorous Acid
Other
Lead sponsor
California Retina Consultants
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 3, 2026, 10:50 PM EDT
Withdrawn Not applicable Interventional

Improving Glare and Visual Comfort for Patients With Visual Impairment

NCT05829135
View directory record Official record
Conditions
Photophobia, Visual Impairment, Low Vision
Interventions
Acuvue Oasys with Transitions
Device
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Davie, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Not listed Not applicable Interventional

Effects of Xal-Ease on Patient Compliance With Xalatan

NCT00573638
View directory record Official record
Conditions
Glaucoma
Interventions
Xal-Ease device to be used with Xalatan eye drops
Device
Lead sponsor
Augusta University
Other
Eligibility
40 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 7, 2008 · Synced Sep 3, 2026, 10:50 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses

NCT00585026
View directory record Official record
Conditions
Refractive Error, Presbyopia, Asthenopia, Eyeglasses
Interventions
D-28 bifocal lenses and frame, Progressive addition computer lenses and frame
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
40 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 14, 2011 · Synced Sep 3, 2026, 10:50 PM EDT
Not listed Phase 4 Interventional

Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL

NCT04863742
View directory record Official record
Conditions
Dry Eye Syndromes
Interventions
Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate
Drug
Lead sponsor
Sight Medical Doctors PLLC
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Brentwood, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Toric Contact Lens Digital Performance and Comfort Study

NCT04772560
View directory record Official record
Conditions
Astigmatism
Interventions
Precision1 for Astigmatism, Precision1 Sphere
Device
Lead sponsor
Kathryn Richdale
Other
Eligibility
18 Years to 39 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dailies Total 1 Sphere Contact Lenses

NCT05239494
View directory record Official record
Conditions
Dry Eye, Contact Lens Complication
Interventions
DT1 Sphere Contact Lenses
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
4
States / cities
Birmingham, Alabama • Pittsburg, Kansas • Granville, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Sep 3, 2026, 10:50 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Refitting Satisfied INFUSE One-Day Multifocal Wearers to DAILIES TOTAL1 Multifocal Contact Lenses

NCT07638943
View directory record Official record
Conditions
Contact Lens Comfort and Successful Refitting, Presbyopia
Interventions
DAILIES TOTAL1 Multifocal (delefilcon A)
Device
Lead sponsor
Gordon Schanzlin New Vision
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Results available

A Multi-Center Investigation of Patient Acceptability of OPTI-FREE RepleniSH® Multi-Purpose Disinfecting Solution (MPDS)

NCT00772707
View directory record Official record
Conditions
Myopia
Interventions
Multi-Purpose Disinfecting Solution (OPTI-FREE RepleniSH), Contact Lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 65 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 6, 2012 · Synced Sep 3, 2026, 10:50 PM EDT
Terminated Not applicable Interventional

Ocular Comfort and Inflammation in Lid Hygiene Therapy

NCT02938078
View directory record Official record
Conditions
Blepharitis
Interventions
Avenova Lid Cleanser
Device
Lead sponsor
Minnesota Eye Consultants, P.A.
Industry
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Sep 3, 2026, 10:50 PM EDT