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ClinicalTrials.gov public records Last synced Oct 4, 2026, 1:25 PM EDT

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Showing 25–48 of 48 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Onychomycosis of Toenails Clear all
Completed Phase 2 Interventional

Absorption and Systemic Study of AN2690 in Patients With Moderate to Severe Onychomycosis (ADME II)

NCT00679601
View directory record Official record
Conditions
Onychomycosis
Interventions
AN2690
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Bryan, Texas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2018 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Iontophoretic Application of Terbinafine Gel to the Large Toe Nail

NCT00768768
View directory record Official record
Conditions
Onychomycosis
Interventions
Electrokinetic Transungual System (ETS) - Terbinafine Gel, ETS-Terbinafine Gel
Other
Lead sponsor
Transport Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Mar 12, 2009 · Synced Oct 4, 2026, 1:25 PM EDT
Recruiting Phase 1 Interventional

Photodynamic Therapy For Onychomycosis

NCT07756671
View directory record Official record
Conditions
Onychomycosis of Toenail
Interventions
ALA 10% gel, PDT, Urea
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 100 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Arlington, Texas • Houston, Texas • Webster, Texas
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 4 Interventional Results available

An Evaluation of the Safety and Pharmacokinetics of Tavaborole Topical Solution for the Treatment of Fungal Disease of the Toenail in Children and Adolescents

NCT03405818
View directory record Official record
Conditions
Onychomycosis, Tinea Unguium
Interventions
Tavaborole 5% Topical Solution
Drug
Lead sponsor
Pfizer
Industry
Eligibility
72 Months to 203 Months
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
12
States / cities
Madera, California • Palo Alto, California • Washington D.C., District of Columbia + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 3 Interventional Results available

Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail

NCT00443898
View directory record Official record
Conditions
Onychomycosis
Interventions
terbinafine, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
12 Years to 75 Years
Enrollment
518 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
20
States / cities
Birmingham, Alabama • San Diego, California • Denver, Colorado + 16 more
Source: ClinicalTrials.gov public record
Updated May 3, 2012 · Synced Oct 4, 2026, 1:25 PM EDT
Active, not recruiting Phase 2 Interventional

Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe Onychomycosis

NCT07065773
View directory record Official record
Conditions
Onychomycosis of Toenail
Interventions
Trichostatin A
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Fremont, California • Denver, Colorado • New Brighton, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 4, 2026, 1:25 PM EDT
Withdrawn Not applicable Interventional

A Study to See if Low Level Laser Light Can Help to Treat Toenail Fungus

NCT03066336
View directory record Official record
Conditions
Onychomycosis of Toenail
Interventions
Erchonia LunulaLaser
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Oct 4, 2026, 1:25 PM EDT
Not listed Phase 2 Interventional

Using Light Therapy to Treat Toe Nail Fungus

NCT00771732
View directory record Official record
Conditions
Onychomycosis
Interventions
light therapy
Device
Lead sponsor
Nomir Medical Technologies
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Southborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2008 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail

NCT01302119
View directory record Official record
Conditions
Onychomycosis of Toenails
Interventions
AN2690 Topical Solution, 5%, Solution Vehicle
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
604 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
26
States / cities
Phoenix, Arizona • Novato, California • Oceanside, California + 22 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Not applicable Interventional Results available

Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail)

NCT03216200
View directory record Official record
Conditions
Onychomycosis of Toenail, Onychomycosis
Interventions
plasma treatment
Device
Lead sponsor
DeviceFarm, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 11, 2019 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Not applicable Interventional Results available

Study of the Use of Low Level Laser Light Therapy to Treat Toenail Fungus

NCT01534689
View directory record Official record
Conditions
Onychomycosis
Interventions
Erchonia FX-405™ Laser
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 11, 2015 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 3 Interventional Results available

Itraconazole Tablets Vs. Itraconazole Capsules vs. Placebo in Onychomycosis of the Toenail.

NCT00356915
View directory record Official record
Conditions
Onychomycosis
Interventions
Itraconazole 100mg capsules, Itraconazole 200mg tablets, Placebo tablets
Drug
Lead sponsor
Stiefel, a GSK Company
Industry
Eligibility
16 Years to 75 Years
Enrollment
1,381 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
52
States / cities
Birmingham, Alabama • Tuscon, Arizona • Hot Springs, Arkansas + 43 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy Evaluation of Topically Applied AN2690 Solutions for Subjects With Onychomycosis

NCT00680134
View directory record Official record
Conditions
Onychomycosis
Interventions
AN2690
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
7
States / cities
Birmingham, Alabama • San Francisco, California • Albuquerque, New Mexico + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2018 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 2Phase 3 Interventional Results available

PinPointe FootLaser for the Treatment of Onychomycosis

NCT00935649
View directory record Official record
Conditions
Infected Toenails, Onychomycosis
Interventions
PinPointe FootLaser
Device
Lead sponsor
PathoLase, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
3
States / cities
Rochester, New York • San Antonio, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 9, 2013 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 2 Interventional

A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail

NCT00385502
View directory record Official record
Conditions
Onychomycosis
Interventions
EcoNail™ (econazole 5%/SEPA® 18% nail lacquer)
Drug
Lead sponsor
Abeona Therapeutics, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
3
States / cities
Tucson, Arizona • New York, New York • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Onychomycosis of the Toenail

NCT02267356
View directory record Official record
Conditions
Onychomycosis
Interventions
VT-1161, Placebo
Drug
Lead sponsor
Viamet
Industry
Eligibility
18 Years to 70 Years
Enrollment
259 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
33
States / cities
Birmingham, Alabama • Tucson, Arizona • Oceanside, California + 29 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 1 Interventional

A Study of the Systemic Absorption of MOB015B

NCT03244280
View directory record Official record
Conditions
Onychomycosis
Interventions
MOB015B
Drug
Lead sponsor
Moberg Pharma AB
Industry
Eligibility
12 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Oct 4, 2026, 1:25 PM EDT
Not listed Phase 2 Interventional

To Evaluate Hallux Terbinafine Subungual Gel (HSG) in the Treatment of Onychomycosis

NCT05135910
View directory record Official record
Conditions
Onychomycosis of Toenail
Interventions
Hallux Terbinafine Subungual Gel
Drug
Lead sponsor
Hallux, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
4
States / cities
Mesa, Arizona • Parker, Colorado • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Oct 4, 2026, 1:25 PM EDT
Terminated Phase 2 Interventional

A Study to Evaluate TMI-358 in the Treatment of Distal Subungual Onychomycosis

NCT01093118
View directory record Official record
Conditions
Distal Subungual Onychomycosis
Interventions
TMI-358, MMI-467
Drug
Lead sponsor
Talima Therapeutics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
7
States / cities
Tucson, Arizona • San Diego, California • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2011 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Phase 2 Interventional

Study of Different Doses of a Novel Treatment for Onychomycosis

NCT00679770
View directory record Official record
Conditions
Distal, Subungual Onychomycosis
Interventions
AN2690, 2.5%, AN2690, 5%, AN2690, 7.5%, Vehicle
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
4
States / cities
Albuquerque, New Mexico • Austin, Texas • Bryan, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2018 · Synced Oct 4, 2026, 1:25 PM EDT
Terminated Phase 3 Interventional

Safety and Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails

NCT01208129
View directory record Official record
Conditions
Onychomycosis
Interventions
NAB001, Placebo control
Drug
Lead sponsor
Promius Pharma, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
25
States / cities
Tucson, Arizona • Phoenix, Arkansas • Rogers, Arkansas + 22 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Not applicable Interventional Results available

Early Feasibility Study to Evaluate the Efficacy and Safety of the RenewalNail™ Plasma Treatment System in Patients With Mild to Moderate Onychomycosis (Fungal Nail)

NCT03072550
View directory record Official record
Conditions
Onychomycosis Due to Trichophyton Rubrum, Onychomycosis Due to Trichophyton Mentagrophytes
Interventions
RenewalNail™ Plasma Treatment System
Device
Lead sponsor
DeviceFarm, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Fremont, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Oct 4, 2026, 1:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy Study of LIQUICURE™ to Treat Toe Nail Fungus

NCT00960089
View directory record Official record
Conditions
Onychomycosis
Interventions
LIQUICURE
Device
Lead sponsor
Chesson Laboratory Associates, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
4
States / cities
Cary, North Carolina • Chapel Hill, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Oct 4, 2026, 1:25 PM EDT
Recruiting Not applicable Interventional

Safety and Efficacy of Next Science Gel on Toenail Fungus

NCT04042857
View directory record Official record
Conditions
Onychomycosis of Toenail
Interventions
Next Science Treatment Gel
Device
Lead sponsor
Next Science TM
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
South Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 2, 2019 · Synced Oct 4, 2026, 1:25 PM EDT